ENSG00000244005


Homo sapiens

Features
Gene ID: ENSG00000244005
  
Biological name :NFS1
  
Synonyms : NFS1 / NFS1, cysteine desulfurase / Q9Y697
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: -1
Band: q11.22
Gene start: 35668055
Gene end: 35699359
  
Corresponding Affymetrix probe sets: 1554321_a_at (Human Genome U133 Plus 2.0 Array)   218455_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000393669
Ensembl peptide - ENSP00000397572
Ensembl peptide - ENSP00000440897
Ensembl peptide - ENSP00000304740
Ensembl peptide - ENSP00000363198
Ensembl peptide - ENSP00000363205
Ensembl peptide - ENSP00000380570
Ensembl peptide - ENSP00000392871
Ensembl peptide - ENSP00000393482
NCBI entrez gene - 9054     See in Manteia.
OMIM - 603485
RefSeq - NM_001198989
RefSeq - NM_021100
RefSeq Peptide - NP_066923
RefSeq Peptide - NP_001185918
swissprot - Q5QP19
swissprot - Q8WV90
swissprot - A2A2M1
swissprot - Q9Y697
swissprot - F2Z2E7
swissprot - F8WB23
swissprot - F8WER8
Ensembl - ENSG00000244005
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfs1ENSDARG00000062237Danio rerio
 NFS1ENSGALG00000001568Gallus gallus
 Nfs1ENSMUSG00000027618Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SCLY / Q96I15 / selenocysteine lyaseENSG0000013233032
AL109827.1ENSG0000027289721


Protein motifs (from Interpro)
Interpro ID Name
 IPR000192  Aminotransferase class V domain
 IPR010240  Cysteine desulfurase IscS
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR016454  Cysteine desulfurase
 IPR020578  Aminotransferase class-V, pyridoxal-phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000096 sulfur amino acid metabolic process TAS
 biological_processGO:0006777 Mo-molybdopterin cofactor biosynthetic process IEA
 biological_processGO:0018283 iron incorporation into metallo-sulfur cluster IDA
 biological_processGO:0032324 molybdopterin cofactor biosynthetic process TAS
 biological_processGO:0044281 small molecule metabolic process TAS
 biological_processGO:0044571 [2Fe-2S] cluster assembly IEA
 biological_processGO:0065003 protein-containing complex assembly TAS
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion TAS
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0031071 cysteine desulfurase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000165060 FXN / Q16595 / frataxin  / complex
 ENSG00000214113 LYRM4 / Q9HD34 / LYR motif containing 4  / complex
 ENSG00000244005 NFS1 / Q9Y697 / NFS1, cysteine desulfurase  / complex
 ENSG00000136003 ISCU / Q9H1K1 / iron-sulfur cluster assembly enzyme  / complex
 ENSG00000124217 MOCS3 / O95396 / molybdenum cofactor synthesis 3  / reaction






 

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