ENSMUSG00000027618


Mus musculus

Features
Gene ID: ENSMUSG00000027618
  
Biological name :Nfs1
  
Synonyms : Cysteine desulfurase, mitochondrial / Nfs1 / Q9Z1J3
  
Possible biological names infered from orthology : AL109827.1 / NFS1, cysteine desulfurase / Q9Y697
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: H1
Gene start: 156123639
Gene end: 156144186
  
Corresponding Affymetrix probe sets: 10489004 (MoGene1.0st)   1416373_at (Mouse Genome 430 2.0 Array)   1431431_a_at (Mouse Genome 430 2.0 Array)   1442017_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139294
Ensembl peptide - ENSMUSP00000029147
Ensembl peptide - ENSMUSP00000105229
NCBI entrez gene - 18041     See in Manteia.
MGI - MGI:1316706
RefSeq - NM_010911
RefSeq - XM_006498897
RefSeq Peptide - NP_035041
swissprot - A6QRH3
swissprot - Q9Z1J3
swissprot - V9GXS4
Ensembl - ENSMUSG00000027618
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfs1ENSDARG00000062237Danio rerio
 NFS1ENSGALG00000001568Gallus gallus
 AL109827.1ENSG00000272897Homo sapiens
 NFS1ENSG00000244005Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Scly / selenocysteine lyase / Q96I15*ENSMUSG0000002630728


Protein motifs (from Interpro)
Interpro ID Name
 IPR000192  Aminotransferase class V domain
 IPR010240  Cysteine desulfurase IscS
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR016454  Cysteine desulfurase
 IPR020578  Aminotransferase class-V, pyridoxal-phosphate binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006777 Mo-molybdopterin cofactor biosynthetic process IEA
 biological_processGO:0018283 iron incorporation into metallo-sulfur cluster IDA
 biological_processGO:0044571 [2Fe-2S] cluster assembly IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0030170 pyridoxal phosphate binding IEA
 molecular_functionGO:0031071 cysteine desulfurase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA


Pathways (from Reactome)
Pathway description
Mitochondrial iron-sulfur cluster biogenesis
Molybdenum cofactor biosynthesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027618 Nfs1 / Q9Z1J3 / Cysteine desulfurase, mitochondrial / Q9Y697* / AL109827.1* / NFS1, cysteine desulfurase*  / complex
 ENSMUSG00000074576 Mocs3 / A2BDX3 / Adenylyltransferase and sulfurtransferase MOCS3 Molybdopterin-synthase adenylyltransferase Molybdopterin-synthase sulfurtransferase / O95396* / molybdenum cofactor synthesis 3*  / reaction
 ENSMUSG00000025825 Iscu / Q9D7P6 / Iron-sulfur cluster assembly enzyme ISCU, mitochondrial / Q9H1K1* / iron-sulfur cluster assembly enzyme*  / complex
 ENSMUSG00000046573 Lyrm4 / Q8K215 / LYR motif-containing protein 4 / Q9HD34* / LYR motif containing 4*  / complex
 ENSMUSG00000059363 Fxn / O35943 / Frataxin, mitochondrial Frataxin intermediate form Frataxin mature form / Q16595* / frataxin*  / complex






 

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