ENSMUSG00000025825


Mus musculus

Features
Gene ID: ENSMUSG00000025825
  
Biological name :Iscu
  
Synonyms : Iron-sulfur cluster assembly enzyme ISCU, mitochondrial / Iscu / Q9D7P6
  
Possible biological names infered from orthology : iron-sulfur cluster assembly enzyme / Q9H1K1
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: F
Gene start: 113772748
Gene end: 113778288
  
Corresponding Affymetrix probe sets: 10461108 (MoGene1.0st)   10524417 (MoGene1.0st)   1452579_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000117053
Ensembl peptide - ENSMUSP00000123237
Ensembl peptide - ENSMUSP00000120553
Ensembl peptide - ENSMUSP00000117973
Ensembl peptide - ENSMUSP00000026937
Ensembl peptide - ENSMUSP00000107930
Ensembl peptide - ENSMUSP00000107931
NCBI entrez gene - 66383     See in Manteia.
MGI - MGI:1913633
RefSeq - NM_025526
RefSeq Peptide - NP_079802
swissprot - F6XUL3
swissprot - F6ZBG7
swissprot - D6RE47
swissprot - Q9D7P6
swissprot - D3Z7W0
swissprot - D3Z0K9
Ensembl - ENSMUSG00000025825
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ISCU (1 of many)ENSDARG00000035596Danio rerio
 iscubENSDARG00000026582Danio rerio
 ISCUENSGALG00000004869Gallus gallus
 ISCUENSG00000136003Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002871  NIF system FeS cluster assembly, NifU, N-terminal
 IPR011339  ISC system FeS cluster assembly, IscU scaffold


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006879 cellular iron ion homeostasis IBA
 biological_processGO:0016226 iron-sulfur cluster assembly IEA
 biological_processGO:0097428 protein maturation by iron-sulfur cluster transfer IBA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005759 mitochondrial matrix IBA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0005506 iron ion binding IEA
 molecular_functionGO:0008198 ferrous iron binding IBA
 molecular_functionGO:0032947 protein-containing complex scaffold activity IEA
 molecular_functionGO:0036455 iron-sulfur transferase activity IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051536 iron-sulfur cluster binding IEA
 molecular_functionGO:0051537 2 iron, 2 sulfur cluster binding IBA
 molecular_functionGO:0051539 4 iron, 4 sulfur cluster binding IBA


Pathways (from Reactome)
Pathway description
Mitochondrial iron-sulfur cluster biogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025825 Iscu / Q9D7P6 / Iron-sulfur cluster assembly enzyme ISCU, mitochondrial / Q9H1K1* / iron-sulfur cluster assembly enzyme*  / complex
 ENSMUSG00000059363 Fxn / O35943 / Frataxin, mitochondrial Frataxin intermediate form Frataxin mature form / Q16595* / frataxin*  / complex
 ENSMUSG00000046573 Lyrm4 / Q8K215 / LYR motif-containing protein 4 / Q9HD34* / LYR motif containing 4*  / complex
 ENSMUSG00000027618 Nfs1 / Q9Z1J3 / Cysteine desulfurase, mitochondrial / Q9Y697* / AL109827.1* / NFS1, cysteine desulfurase*  / complex






 

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