ENSG00000132330


Homo sapiens

Features
Gene ID: ENSG00000132330
  
Biological name :SCLY
  
Synonyms : Q96I15 / SCLY / selenocysteine lyase
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q37.3
Gene start: 238060889
Gene end: 238099413
  
Corresponding Affymetrix probe sets: 219808_at (Human Genome U133 Plus 2.0 Array)   221575_at (Human Genome U133 Plus 2.0 Array)   59705_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000406710
Ensembl peptide - ENSP00000416344
Ensembl peptide - ENSP00000414165
Ensembl peptide - ENSP00000414053
Ensembl peptide - ENSP00000254663
Ensembl peptide - ENSP00000387162
Ensembl peptide - ENSP00000391361
Ensembl peptide - ENSP00000392517
Ensembl peptide - ENSP00000401401
Ensembl peptide - ENSP00000402078
Ensembl peptide - ENSP00000404444
Ensembl peptide - ENSP00000404473
Ensembl peptide - ENSP00000405907
NCBI entrez gene - 51540     See in Manteia.
OMIM - 611056
RefSeq - NM_016510
RefSeq Peptide - NP_057594
swissprot - F8WCL3
swissprot - H7C1N7
swissprot - H7C1S7
swissprot - H7C277
swissprot - H7C280
swissprot - H7C2H3
swissprot - H7C2M1
swissprot - H7C3V9
swissprot - H7C4A1
swissprot - C9JNL5
swissprot - Q96I15
swissprot - A0A0A0MQU4
swissprot - F8WBU3
Ensembl - ENSG00000132330
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sclyENSDARG00000073813Danio rerio
 SCLYENSGALG00000030194Gallus gallus
 SclyENSMUSG00000026307Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
NFS1 / Q9Y697 / NFS1, cysteine desulfuraseENSG0000024400532
AL109827.1ENSG000002728976


Protein motifs (from Interpro)
Interpro ID Name
 IPR000192  Aminotransferase class V domain
 IPR015421  Pyridoxal phosphate-dependent transferase, major domain
 IPR015422  Pyridoxal phosphate-dependent transferase domain 1
 IPR015424  Pyridoxal phosphate-dependent transferase
 IPR016454  Cysteine desulfurase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001887 selenium compound metabolic process TAS
 biological_processGO:0006520 cellular amino acid metabolic process TAS
 biological_processGO:0016261 selenocysteine catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:1902494 catalytic complex IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0009000 selenocysteine lyase activity TAS
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0070279 vitamin B6 binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of ingested SeMet, Sec, MeSec into H2Se


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000132330 SCLY / Q96I15 / selenocysteine lyase  / complex






 

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