ENSG00000125686


Homo sapiens

Features
Gene ID: ENSG00000125686
  
Biological name :MED1
  
Synonyms : MED1 / mediator complex subunit 1 / Q15648
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q12
Gene start: 39404285
Gene end: 39451286
  
Corresponding Affymetrix probe sets: 203496_s_at (Human Genome U133 Plus 2.0 Array)   203497_at (Human Genome U133 Plus 2.0 Array)   225452_at (Human Genome U133 Plus 2.0 Array)   225456_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000300651
Ensembl peptide - ENSP00000377828
Ensembl peptide - ENSP00000462441
Ensembl peptide - ENSP00000463307
NCBI entrez gene - 5469     See in Manteia.
OMIM - 604311
RefSeq - XM_017024779
RefSeq - NM_004774
RefSeq - XM_005257465
RefSeq - XM_006721957
RefSeq Peptide - NP_004765
swissprot - Q15648
swissprot - J3QKZ7
swissprot - J3KSD7
Ensembl - ENSG00000125686
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med1ENSDARG00000075340Danio rerio
 MED1ENSGALG00000001708Gallus gallus
 Med1ENSMUSG00000018160Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019680  Mediator complex, subunit Med1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0000902 cell morphogenesis IMP
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0002088 lens development in camera-type eye IEA
 biological_processGO:0002154 thyroid hormone mediated signaling pathway IMP
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IEA
 biological_processGO:0003406 retinal pigment epithelium development IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006356 regulation of transcription by RNA polymerase I IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter TAS
 biological_processGO:0006590 thyroid hormone generation IEA
 biological_processGO:0006702 androgen biosynthetic process IMP
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007420 brain development IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007595 lactation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009887 animal organ morphogenesis IEA
 biological_processGO:0010628 positive regulation of gene expression IMP
 biological_processGO:0010839 negative regulation of keratinocyte proliferation IMP
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019216 regulation of lipid metabolic process TAS
 biological_processGO:0030216 keratinocyte differentiation IMP
 biological_processGO:0030224 monocyte differentiation IEA
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway IDA
 biological_processGO:0030521 androgen receptor signaling pathway IDA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IEA
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IEA
 biological_processGO:0033598 mammary gland epithelial cell proliferation IEA
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0035050 embryonic heart tube development IEA
 biological_processGO:0035116 embryonic hindlimb morphogenesis IEA
 biological_processGO:0035162 embryonic hemopoiesis IEA
 biological_processGO:0035357 peroxisome proliferator activated receptor signaling pathway IEA
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IEA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IEA
 biological_processGO:0043010 camera-type eye development IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045444 fat cell differentiation IDA
 biological_processGO:0045618 positive regulation of keratinocyte differentiation IMP
 biological_processGO:0045648 positive regulation of erythrocyte differentiation IMP
 biological_processGO:0045665 negative regulation of neuron differentiation IEA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048821 erythrocyte development IEA
 biological_processGO:0048822 enucleate erythrocyte development IEA
 biological_processGO:0051726 regulation of cell cycle NAS
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IEA
 biological_processGO:0060744 mammary gland branching involved in thelarche IEA
 biological_processGO:0060745 mammary gland branching involved in pregnancy IEA
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IEA
 biological_processGO:0070318 positive regulation of G0 to G1 transition IEA
 biological_processGO:0070371 ERK1 and ERK2 cascade IDA
 biological_processGO:0070562 regulation of vitamin D receptor signaling pathway IEA
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus IDA
 biological_processGO:0071383 cellular response to steroid hormone stimulus IDA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:2000273 positive regulation of signaling receptor activity IMP
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IEA
 biological_processGO:2001141 regulation of RNA biosynthetic process IMP
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0016592 mediator complex IMP
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IEA
 molecular_functionGO:0001047 core promoter binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0003712 transcription coregulator activity IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016922 nuclear receptor binding IPI
 molecular_functionGO:0030331 estrogen receptor binding IPI
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity NAS
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IMP
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding IEA
 molecular_functionGO:0036033 mediator complex binding IDA
 molecular_functionGO:0042809 vitamin D receptor binding IEA
 molecular_functionGO:0042974 retinoic acid receptor binding IPI
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding IPI
 molecular_functionGO:0046966 thyroid hormone receptor binding IEA
 molecular_functionGO:0050693 LBD domain binding IPI
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
Generic Transcription Pathway
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Circadian Clock
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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