ENSMUSG00000018160


Mus musculus

Features
Gene ID: ENSMUSG00000018160
  
Biological name :Med1
  
Synonyms : Med1 / Mediator of RNA polymerase II transcription subunit 1 / Q925J9
  
Possible biological names infered from orthology : mediator complex subunit 1 / Q15648
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: D
Gene start: 98152154
Gene end: 98193293
  
Corresponding Affymetrix probe sets: 10390595 (MoGene1.0st)   1421906_at (Mouse Genome 430 2.0 Array)   1421907_at (Mouse Genome 430 2.0 Array)   1439408_a_at (Mouse Genome 430 2.0 Array)   1447450_at (Mouse Genome 430 2.0 Array)   1448708_at (Mouse Genome 430 2.0 Array)   1450402_at (Mouse Genome 430 2.0 Array)   1453972_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000018304
Ensembl peptide - ENSMUSP00000090411
Ensembl peptide - ENSMUSP00000103169
NCBI entrez gene - 19014     See in Manteia.
MGI - MGI:1100846
RefSeq - XM_011248799
RefSeq - NM_001080118
RefSeq - NM_013634
RefSeq - NM_134027
RefSeq - XM_006532503
RefSeq - XM_006532504
RefSeq - XM_006532505
RefSeq Peptide - NP_001073587
RefSeq Peptide - NP_038662
RefSeq Peptide - NP_598788
swissprot - Q925J9
swissprot - B1AQH6
Ensembl - ENSMUSG00000018160
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 med1ENSDARG00000075340Danio rerio
 MED1ENSGALG00000001708Gallus gallus
 MED1ENSG00000125686Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR019680  Mediator complex, subunit Med1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IMP
 biological_processGO:0000902 cell morphogenesis ISS
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001892 embryonic placenta development IMP
 biological_processGO:0002088 lens development in camera-type eye IMP
 biological_processGO:0002154 thyroid hormone mediated signaling pathway ISO
 biological_processGO:0003222 ventricular trabecula myocardium morphogenesis IMP
 biological_processGO:0003406 retinal pigment epithelium development IMP
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006356 regulation of transcription by RNA polymerase I ISO
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IC
 biological_processGO:0006367 transcription initiation from RNA polymerase II promoter ISS
 biological_processGO:0006590 thyroid hormone generation IMP
 biological_processGO:0006702 androgen biosynthetic process ISO
 biological_processGO:0007275 multicellular organism development IMP
 biological_processGO:0007420 brain development IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007595 lactation IMP
 biological_processGO:0008284 positive regulation of cell proliferation IMP
 biological_processGO:0009887 animal organ morphogenesis IMP
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010839 negative regulation of keratinocyte proliferation ISS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0030216 keratinocyte differentiation ISS
 biological_processGO:0030224 monocyte differentiation IMP
 biological_processGO:0030518 intracellular steroid hormone receptor signaling pathway ISS
 biological_processGO:0030521 androgen receptor signaling pathway ISS
 biological_processGO:0031100 animal organ regeneration IMP
 biological_processGO:0033148 positive regulation of intracellular estrogen receptor signaling pathway IMP
 biological_processGO:0033160 positive regulation of protein import into nucleus, translocation IMP
 biological_processGO:0033598 mammary gland epithelial cell proliferation IMP
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0035116 embryonic hindlimb morphogenesis IMP
 biological_processGO:0035162 embryonic hemopoiesis IMP
 biological_processGO:0035357 peroxisome proliferator activated receptor signaling pathway IMP
 biological_processGO:0035729 cellular response to hepatocyte growth factor stimulus IMP
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0042789 mRNA transcription by RNA polymerase II IMP
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0045444 fat cell differentiation ISO
 biological_processGO:0045618 positive regulation of keratinocyte differentiation ISO
 biological_processGO:0045648 positive regulation of erythrocyte differentiation ISS
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II ISO
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0048822 enucleate erythrocyte development IMP
 biological_processGO:0060335 positive regulation of interferon-gamma-mediated signaling pathway IMP
 biological_processGO:0060744 mammary gland branching involved in thelarche IMP
 biological_processGO:0060745 mammary gland branching involved in pregnancy IMP
 biological_processGO:0060750 epithelial cell proliferation involved in mammary gland duct elongation IMP
 biological_processGO:0070318 positive regulation of G0 to G1 transition IMP
 biological_processGO:0070371 ERK1 and ERK2 cascade ISO
 biological_processGO:0070562 regulation of vitamin D receptor signaling pathway IMP
 biological_processGO:0071364 cellular response to epidermal growth factor stimulus ISS
 biological_processGO:0071383 cellular response to steroid hormone stimulus ISO
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IBA
 biological_processGO:2000273 positive regulation of signaling receptor activity ISO
 biological_processGO:2000347 positive regulation of hepatocyte proliferation IMP
 biological_processGO:2001141 regulation of RNA biosynthetic process ISS
 cellular_componentGO:0000151 ubiquitin ligase complex IEA
 cellular_componentGO:0000785 chromatin IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005730 nucleolus ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016592 mediator complex ISO
 cellular_componentGO:0032993 protein-DNA complex IEA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000979 RNA polymerase II core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IMP
 molecular_functionGO:0001047 core promoter binding ISS
 molecular_functionGO:0003677 DNA binding IDA
 molecular_functionGO:0003682 chromatin binding ISO
 molecular_functionGO:0003712 transcription coregulator activity ISO
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0016922 nuclear receptor binding ISO
 molecular_functionGO:0030331 estrogen receptor binding ISO
 molecular_functionGO:0030374 nuclear receptor transcription coactivator activity ISS
 molecular_functionGO:0030375 thyroid hormone receptor coactivator activity IBA
 molecular_functionGO:0031490 chromatin DNA binding IEA
 molecular_functionGO:0035257 nuclear hormone receptor binding ISO
 molecular_functionGO:0036033 mediator complex binding ISO
 molecular_functionGO:0042809 vitamin D receptor binding IBA
 molecular_functionGO:0042974 retinoic acid receptor binding IBA
 molecular_functionGO:0042975 peroxisome proliferator activated receptor binding ISO
 molecular_functionGO:0046966 thyroid hormone receptor binding IBA
 molecular_functionGO:0050693 LBD domain binding ISO
 molecular_functionGO:0061630 ubiquitin protein ligase activity IEA


Pathways (from Reactome)
Pathway description
Generic Transcription Pathway
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Estrogen-dependent gene expression


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000266 abnormal cardiac morphology "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000274 enlarged heart "increase over normal size of the heart" [J:29971]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000278 abnormal myocardial fiber morphology "malformed or poorly developed cardiac muscle fibers, the multinucleated muscle cells of the heart" [J:18048]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000279 ventricular hypoplasia "reduction in cell number of one or both of the two lower chambers of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:61790]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000280 thin ventricular wall "decreased depth of the cardiac wall of the heart ventricles" [J:45302]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Med1tm1Mpk/Med1tm1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0000295 poorly developed ventricular trabeculae "retarded differentation of the supporting bundles of muscular fibers lining the walls of the ventricles of the heart" [J:29971]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Med1tm1Mpk/Med1tm1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0000433 microcephaly "an abnormally small head" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000596 abnormal liver development "anomalous differentiation of the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0000602 enlarged sinusoidal spaces "larger than normal sized cavities in the liver " [J:23170]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0000607 abnormal hepatocyte morphology "malformation of the main structural component of the liver; these are specialized epithelial cells normally organize into interconnected plates called lobules" [J:23170, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Asgr2tm1Her/Asgr2+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0000628 abnormal mammary gland development "aberration in the differentiation of the mammary gland during early embryogenesis or during sexual maturity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Camk4tm1Tsmi/Camk4tm1Tsmi
Genetic Background: B6N.129S-Camk4tm1Tsmi

 MP:0000662 abnormal branching of the mammary ductal tree "anomaly in the development of the channels that secrete milk and direct milk to the nipple" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Camk4tm1Tsmi/Camk4tm1Tsmi
Genetic Background: B6N.129S-Camk4tm1Tsmi

 MP:0000934 abnormal telencephalon development "malformed or incomplete differentiation of the anterior division of the embryonic prosencephalon " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001255 decreased body height "decreased shoulder to floor distance compared to controls" [dlb:Donna Burkart, Mouse Genome Informatics Curator]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Gdnftm1Lmgd/Gdnf+
Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S1/Sv * 129X1/SvJ)

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001614 abnormal vasculature "anomalies in the structure of development of the network of tubes that carries blood through the body" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001716 abnormal placental labyrinth "malformed structure where embryonic blood vessels are surrounded by trophoblast cells and maternal blood" [J:23171]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Med1tm1Rgr/Med1+
Genetic Background: either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J)

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nptnpitch/Nptnpitch
Genetic Background: involves: C3H * C57BL/6J

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002086 abnormal extraembryonic tissue morphology "structural abnormality or development of the membranes involved with embryonic protection and nutrition" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:40594, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002109 abnormal limb morphology "abnormal development of limbs resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Leprdb-5J/Leprdb-5J
Genetic Background: NOD/ShiLtJ

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0002123 abnormal hematopoiesis "abnormal development of the enucleated fetal and adult erythrocytes that develop in the aorta, genital ridge and mesonephros region and later in the fetal and adult liver" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002152 abnormal brain morphology "anomalous structure of or abnormal development of the brain, one of the two components of the central nervous system and the center of thought and emotion; controls coordination, bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, http://cancerweb.ncl.ac.uk]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002189 abnormal myocardial trabeculae morphology "malformation of the supporting bundles of muscular fibers lining the walls of the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002264 abnormal bronchus morphology "any structural anomaly of of the upper conducting airways of the lung; these airways arise from the terminus of the trachea " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002652 thin myocardial wall "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0002740 heart hypoplasia "decreased cell number in the heart" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:77765]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0002795 dilated cardiomyopathy "decreased function of the heart associated with cardiac enlargement and congestive heart failure" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0002925 abnormal cardiovascular development "aberrant formation or incomplete differentiation of the cardiovascular system" [RGD:Rat Genome Database submission]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003070 increased vascular permeability "greater or faster ability of the blood vessels to permit the passage of substances such as fluid, heat, or gases" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003077 abnormal cell cycle "failure to progress or abnormal progression through the stages of of the cell cycle" [smb:Susan M. Bello, Mouse Genome Informatics Curator, J:91266]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003140 dilated atria "an expansion in the volume of one or both of the upper chambers of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003202 abnormal neuron apoptosis "change in the timing or the number of neurons undergoing programmed cell death" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003222 increased cardiomyocyte apoptosis "increase in the number of cardiac muscle cells undergoing programmed cell death" [RGD:Rat Genome Database submission]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003231 abnormal placental vasculature "malformation in the vessels of the placenta" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93157]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003232 abnormal forebrain development "anomaly in the formation or patterning of the anterior primitive cerebral vesicle; most rostral of three primary vesicles of the embryonic neural tube" [J:93081, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003237 abnormal lens epithelium morphology "malformation in the one or more of the layers of epithelial cells in the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003503 decreased activity of thyroid 
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Allelic Composition: Med1tm1Rgr/Med1+
Genetic Background: either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J)

 MP:0003542 abnormal vascular endothelial cell development "malformation or aberrant differentiation of the cells that line the vasculature" [J:95387, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003632 abnormal nervous system morphology 
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0003828 pulmonary edema "an accumulation of an excessive amount of watery fluid in the lung " [J:44108, anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Med1tm1Mpk/Med1tm1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0004057 thin myocardial compact layer "reduced thickness of the outer, dense layer of the myocardium " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0004091 abnormal Z lines "any structural abnormality in the cross-striation bisecting the I band of striated muscle myofibrils and serving as the anchoring point of actin filaments at either end of the sarcomere" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0004255 abnormal spongiotrophoblast layer morphology "anomaly in the structure of the outer structural layer of the rodent placenta" [PMID:11433360]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004261 abnormal embryonic neuroepithelium morphology "any structural anomaly in the epithelial cell layer that lines the neural tube and develops into the nervous system and into the neural crest cells" [ISBN:0838580343 "Kandel ER, et al. Principles of Neural Science, 3rd edition", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0005033 abnormal trophoblast cells "anomaly of the cells covering the blastocyst that erode the uterine mucosa and contribute to the formation of the placenta " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator, J:57761]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005134 decreased thyroid-stimulating hormone level "less than expected concentration of the hormone that stimulates the growth and function of the thyroid gland" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm1Rgr/Med1+
Genetic Background: either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J)

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0005266 abnormal metabolism "anomalous chemical and physical changes occurring in tissue " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm1Rgr/Med1+
Genetic Background: either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J)

 MP:0005312 pericardial effusion "escape of fluid from blood vessels or lymphatics into the fibrous sac surrounding the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005478 decreased circulating thyroxine level "less than the normal blood concentration of the major hormone dervied from the thryoid gland; it normally affects cellular metabolism" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Med1tm1Rgr/Med1+
Genetic Background: either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J)

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Med1tm1Rgr/Med1+
Genetic Background: either: 129X1/SvJ or (involves: 129X1/SvJ * C57BL/6J)

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005601 increased angiogenesis "enhanced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005608 cardiac interstitial fibrosis "formation of fibrous tissue within the interstices of the heart as a result of repair or a reactive process" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006062 abnormal vena cava morphology "structural malformation of either of the two largest veins in the body " [smb:Susan M Bello, Mouse Genome Informatics Curator, Taber s Cyclopedic Medical Dictionary:19th edition: ISBN N 0-8036-0655-99]
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Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0006138 congestive heart failure "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0006372 impaired placental function "reduction in the ability of the placenta to supply nutrients or remove waste" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008022 dilated heart ventricles "the lumenal space of the lower chambers of the heart is increased in volume or area, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0008253 absent megakaryocytes "absence of giant cells 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow; mature blood platelets are released from its cytoplasm" [CL:0000556, ISBN:0721601464]
Show

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0009395 persistence of primitive erythrocytes "presence of increased numbers of nucleated red blood cells at stages when these cells are normally replaced by mature, enucleated, red blood cells" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Med1tm1Mpk/Med1tm1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0009504 abnormal mammary gland epithelium morphology "any structural anomaly of the epithelial layer of the luminal surfaces of the mammary gland" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Camk4tm1Tsmi/Camk4tm1Tsmi
Genetic Background: B6N.129S-Camk4tm1Tsmi

 MP:0010174 decreased mammary gland epithelium proliferation "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Camk4tm1Tsmi/Camk4tm1Tsmi
Genetic Background: B6N.129S-Camk4tm1Tsmi

 MP:0010500 myocardium hypoplasia "underdevelopment or reduced size, usually due to a reduced number of cells, of the heart myocardium" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0010503 myocardial trabeculae hypoplasia "underdevelopment or reduced size of the supporting bundles of muscular fibers lining the walls of the heart, usually due to a reduced number of cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Med1tm1Jkr/Med1tm1Jkr
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Med1tm1Mpk/Med1tm1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

Allelic Composition: Med1tm1.1Mpk/Med1tm1.1Mpk
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0011107 partial embryonic lethality before turning of embryo "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between somite formation and the initiation of embryo turning (Mus: E8 to less than E9)" [MGI:csmith]
Show

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011639 decreased mitochondrial DNA content "less than expected amount of DNA contained within the mirochondria of a eukaryotic cell" [MGI:csmith]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0011704 decreased fibroblast proliferation "reduction in the expansion rate of a fibroblast cell population by cell division" [MGI:csmith]
Show

Allelic Composition: H2afxtm1Fwa/H2afx+,Trp53tm1Brd/Trp53tm1Brd
Genetic Background: involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6

 MP:0011925 abnormal heart echocardiography feature "any anomaly in echocardiographic representation of systolic and diastolic function, ventricular compliance, valvular function, or interventricular septum features" [MPD:Molly]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,A1cfTg(Myh6-cre/Esr1*)1Jmk/A1cf+
Genetic Background: involves: 129P2/OlaHsd * FVB/N

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
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Allelic Composition: Med1tm2Jkr/Med1tm2Jkr,Tg(Myh6-cre)2182Mds/0
Genetic Background: involves: 129P2/OlaHsd * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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