ENSG00000127129


Homo sapiens

Features
Gene ID: ENSG00000127129
  
Biological name :EDN2
  
Synonyms : EDN2 / endothelin 2 / P20800
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: -1
Band: p34.2
Gene start: 41478775
Gene end: 41484673
  
Corresponding Affymetrix probe sets: 206758_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000361668
NCBI entrez gene - 1907     See in Manteia.
OMIM - 131241
RefSeq - NM_001956
RefSeq - NM_001302269
RefSeq Peptide - NP_001289198
RefSeq Peptide - NP_001947
swissprot - P20800
Ensembl - ENSG00000127129
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edn2ENSDARG00000070578Danio rerio
 EDN2ENSGALG00000000667Gallus gallus
 Edn2ENSMUSG00000028635Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EDN1 / P05305 / endothelin 1ENSG0000007840134
EDN3 / P14138 / endothelin 3ENSG0000012420531


Protein motifs (from Interpro)
Interpro ID Name
 IPR001928  Endothelin-like toxin
 IPR015658  Endothelin-2
 IPR019764  Endothelin-like toxin, conserved site
 IPR020475  Endothelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IDA
 biological_processGO:0003058 hormonal regulation of the force of heart contraction TAS
 biological_processGO:0003099 positive regulation of the force of heart contraction by chemical signal TAS
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IC
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IDA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010460 positive regulation of heart rate IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014824 artery smooth muscle contraction IDA
 biological_processGO:0014826 vein smooth muscle contraction IDA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0019722 calcium-mediated signaling IDA
 biological_processGO:0030593 neutrophil chemotaxis IDA
 biological_processGO:0042116 macrophage activation IDA
 biological_processGO:0042310 vasoconstriction IDA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IDA
 biological_processGO:0048246 macrophage chemotaxis IDA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity IEA
 biological_processGO:0097009 energy homeostasis IEA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005179 hormone activity IDA
 molecular_functionGO:0031708 endothelin B receptor binding IPI


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136160 EDNRB / P24530 / endothelin receptor type B  / reaction / complex
 ENSG00000151617 EDNRA / P25101 / endothelin receptor type A  / reaction / complex






 

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