ENSMUSG00000028635


Mus musculus

Features
Gene ID: ENSMUSG00000028635
  
Biological name :Edn2
  
Synonyms : Edn2 / Endothelin-2 / P22389
  
Possible biological names infered from orthology : P20800
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: D2.1
Gene start: 120161206
Gene end: 120167360
  
Corresponding Affymetrix probe sets: 10507692 (MoGene1.0st)   1449161_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000030384
NCBI entrez gene - 13615     See in Manteia.
MGI - MGI:95284
RefSeq - NM_007902
RefSeq Peptide - NP_031928
swissprot - P22389
Ensembl - ENSMUSG00000028635
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edn2ENSDARG00000070578Danio rerio
 EDN2ENSGALG00000000667Gallus gallus
 EDN2ENSG00000127129Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Edn1 / P22387 / Endothelin-1 Big endothelin-1 / P05305* / endothelin 1*ENSMUSG0000002136730
Edn3 / P48299 / Endothelin-3 / P14138*ENSMUSG0000002752428


Protein motifs (from Interpro)
Interpro ID Name
 IPR001928  Endothelin-like toxin
 IPR015658  Endothelin-2
 IPR019764  Endothelin-like toxin, conserved site
 IPR020475  Endothelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001516 prostaglandin biosynthetic process IDA
 biological_processGO:0001659 temperature homeostasis IMP
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IEA
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014824 artery smooth muscle contraction IEA
 biological_processGO:0014826 vein smooth muscle contraction IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0042116 macrophage activation IEA
 biological_processGO:0042310 vasoconstriction ISO
 biological_processGO:0045987 positive regulation of smooth muscle contraction IDA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0048246 macrophage chemotaxis IEA
 biological_processGO:0048286 lung alveolus development IMP
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity IMP
 biological_processGO:0097009 energy homeostasis IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031708 endothelin B receptor binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
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Allelic Composition: Tex19.1tm1.2Ics/Tex19.1tm1.2Ics
Genetic Background: involves: C57BL/6

Allelic Composition: Edn2tm1.2Nat/Edn2tm1.2Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001732 postnatal growth retardation "slow or limited development after birth " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002318 hypercapnia "elevated concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002575 increased circulating ketone body level "greater than the normal amount of acetoacetate, 3-hydroxybutyrate and acteone in the blood; produced by fatty acid and carbohydrate metabolism and seen in conditions such as starvation and diabetes mellitus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator, J:71968]
Show

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002608 increased hematocrit "greater than average percentage of a volume of a blood sample occupied by red blood cells" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0002971 abnormal brown fat morphology "defect in the thermogenic form of adipose tissue" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003016 increased circulating bicarbonate level "elevated concentration of inorganic salts that contain the -HCO3 radical in the circulation, which are an important factor in regulating the pH of the blood " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003030 acidemia "increased concentration of H-ion in the blood or a fall below normal in pH" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003031 acidosis "a pathological state characterized by an increase in the hydrogen ion concentration of arterial blood; caused by an decrease in the concentration of alkaline compounds, or by a increase in the concentration of acidic compounds or carbon dioxide to the body fluids" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0003948 abnormal gas homeostasis "anomaly in the state of equilibrium in the body of gaseous elements in animal tissues or blood" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005479 decreased circulating triiodothyronine level "less than the normal blood concentration of this hormone synthesized and secreted by the thyroid; normally, this is the main thyroid hormone used by the tissues " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005534 decreased body temperature "less than the level of heat natural to a living being" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005560 decreased circulating glucose level "less than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [RGD:Rat Genome Database submission, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008032 abnormal lipolysis "anomaly in the process of the hydrolysis of fat into free fatty acids " [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0008821 increased blood uric acid level "greater concentration in the blood of the final oxidation product of purine catabolism in humans and primates, but which in rodents and most other mammals is normally is further oxidized by uricase to allantoin that is excreted in the urine" [MESH:D03.132.960.877, MGI:brs "Beverly Richards-Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0009642 abnormal blood homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions or chemical or protein composition of the blood" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0009763 increased sensitivity to induced morbidity/mortality "decrease in the amount of an external agent required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0010025 decreased total body fat amount "less than the normal total amount of connective tissue composed of fat cells within the entire body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010902 abnormal pulmonary alveolar sac morphology "any structural anomaly of the small terminal dilation of the alveolar ducts around which the alveoli form pocket-like clusters" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0010937 increased total lung capacity "greater volume of air contained in the lungs at the end of maximal inspiration" [MGI:csmith]
Show

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0011049 impaired adaptive thermogenesis "inability or reduced ability to produce heat in response to short term environmental changes, such as stress, diet or reduced temperature, often resulting in metabolic inefficiency or death" [MGI:csmith, PMID:16836744]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
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Allelic Composition: Edn2tm1.2Nat/Edn2tm1.2Nat
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Sall4tm1Yam/Sall4+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

 MP:0011285 increased circulating erythropoietin level "greater blood concentration of a sialic acid-containing glycoprotein hormone that enhances erythropoiesis and participates in wound healing; it is formed in the kidney and liver and can be detected in plasma and urine" [ISBN:0-683-40008-8, MGI:csmith]
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Allelic Composition: Edn2tm1Ywa/Edn2tm1Ywa
Genetic Background: involves: 129S6/SvEvTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031616 Ednra / Q61614 / Endothelin-1 receptor / P25101* / endothelin receptor type A*  / complex / reaction
 ENSMUSG00000022122 Ednrb / P48302 / Endothelin receptor type B / P24530*  / complex / reaction






 

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