ENSMUSG00000021367


Mus musculus

Features
Gene ID: ENSMUSG00000021367
  
Biological name :Edn1
  
Synonyms : Edn1 / Endothelin-1 Big endothelin-1 / P22387
  
Possible biological names infered from orthology : endothelin 1 / P05305
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: A4
Gene start: 42301476
Gene end: 42307990
  
Corresponding Affymetrix probe sets: 10404783 (MoGene1.0st)   1451924_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000021796
NCBI entrez gene - 13614     See in Manteia.
MGI - MGI:95283
RefSeq - NM_010104
RefSeq Peptide - NP_034234
swissprot - P22387
swissprot - Q544E0
Ensembl - ENSMUSG00000021367
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edn1ENSDARG00000036912Danio rerio
 EDN1ENSGALG00000012735Gallus gallus
 EDN1ENSG00000078401Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Edn2 / P22389 / Endothelin-2 / P20800*ENSMUSG0000002863526
Edn3 / P48299 / Endothelin-3 / P14138*ENSMUSG0000002752424


Protein motifs (from Interpro)
Interpro ID Name
 IPR001928  Endothelin-like toxin
 IPR019764  Endothelin-like toxin, conserved site
 IPR020475  Endothelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IMP
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IMP
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IMP
 biological_processGO:0001821 histamine secretion IEA
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin IEA
 biological_processGO:0006885 regulation of pH IDA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IGI
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0007585 respiratory gaseous exchange IMP
 biological_processGO:0007589 body fluid secretion IMP
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010193 response to ozone IEA
 biological_processGO:0010259 multicellular organism aging IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IEA
 biological_processGO:0014032 neural crest cell development IMP
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0014824 artery smooth muscle contraction IEA
 biological_processGO:0014826 vein smooth muscle contraction IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030072 peptide hormone secretion IEA
 biological_processGO:0030185 nitric oxide transport IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031583 phospholipase D-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0032269 negative regulation of cellular protein metabolic process IEA
 biological_processGO:0032308 positive regulation of prostaglandin secretion IEA
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0033574 response to testosterone IEA
 biological_processGO:0034392 negative regulation of smooth muscle cell apoptotic process IEA
 biological_processGO:0034696 response to prostaglandin F IEA
 biological_processGO:0035094 response to nicotine IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035810 positive regulation of urine volume IMP
 biological_processGO:0035815 positive regulation of renal sodium excretion IMP
 biological_processGO:0035994 response to muscle stretch IEA
 biological_processGO:0042045 epithelial fluid transport IEA
 biological_processGO:0042310 vasoconstriction ISO
 biological_processGO:0042313 protein kinase C deactivation IEA
 biological_processGO:0042474 middle ear morphogenesis IMP
 biological_processGO:0042482 positive regulation of odontogenesis IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0043179 rhythmic excitation IMP
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0044321 response to leptin IEA
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IEA
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0046888 negative regulation of hormone secretion IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0048514 blood vessel morphogenesis IMP
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050880 regulation of blood vessel size IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IDA
 biological_processGO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0051899 membrane depolarization IEA
 biological_processGO:0051930 regulation of sensory perception of pain IEA
 biological_processGO:0060137 maternal process involved in parturition IEA
 biological_processGO:0060298 positive regulation of sarcomere organization IEA
 biological_processGO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity IEA
 biological_processGO:0061051 positive regulation of cell growth involved in cardiac muscle cell development IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071375 cellular response to peptide hormone stimulus IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IEA
 biological_processGO:0071389 cellular response to mineralocorticoid stimulus IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071456 cellular response to hypoxia IEA
 biological_processGO:0071548 response to dexamethasone IEA
 biological_processGO:0071559 response to transforming growth factor beta IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 biological_processGO:1902074 response to salt IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0033093 Weibel-Palade body IEA
 cellular_componentGO:0045178 basal part of cell IEA
 cellular_componentGO:0048237 rough endoplasmic reticulum lumen IEA
 molecular_functionGO:0005102 signaling receptor binding IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0031707 endothelin A receptor binding IEA
 molecular_functionGO:0031708 endothelin B receptor binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000049 abnormal middle ear morphology "malformation or malfunction of any components of the tympanic cavity or its ossicles" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0000111 cleft palate "congenital fissure of the tissues normally uniting to form the palate" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0000114 cleft chin "incomplete fusion of the chin; usually a fissure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:42035]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0000231 hypertension "sustained high blood pressure at a level that is likely to result in cardiovascular disease and/or other pathological states" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0000272 abnormal aorta morphology "structural anomaly of the main trunk of the systemic arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000273 overriding aorta "congenitally mispositioned aorta where the origin straddles the ventral septum and so receives ejected blood from the right ventricle as well as the left." [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cml, J:67826]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000284 double outlet right ventricle "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0000428 abnormal craniofacial morphology "anomalous structure or development of the face and/or cranium" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Slc14a2tm1Suc/Slc14a2tm1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0000460 mandible hypoplasia "arrested growth or atrophy of the lower bony framework of the mouth where the inferior teeth are held" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator, J:54637]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0000762 abnormal tongue morphology "anomalous structure or development of the mobile mass of muscular tissue and surrounding epithelial tissue occupying the cavity of the mouth and forming part of the floor" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0002108 abnormal muscle morphology "abnormal development of muscle tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0002127 abnormal cardiovascular system morphology "abnormal development of the heart or vascular tissue resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002136 abnormal kidney physiology "altered ability or inability to excrete urine, not due to anatomical defect" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0002318 hypercapnia "elevated concentration of CO2 in the blood, alveoli or other tissues resulting in the increased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1Ywa/Ednrb+
Genetic Background: involves: 129S/SvEvBrd

 MP:0002329 abnormal blood gas "anomaly in the amount of oxygen and carbon dioxide in the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ednrbtm1Ywa/Ednrb+
Genetic Background: involves: 129S/SvEvBrd

 MP:0002672 abnormal branchial arch artery morphology "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002754 dilated right ventricle "an expansion in the volume of the lower right chamber of the heart" [J:82859, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0002842 increased blood pressure "increased tension of the blood within the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0003056 abnormal hyoid bone "anomalous structure of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, hdene:Howard Dene, Mouse Genome Informatics Curator]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0003620 decreased urine output "decreased volume of urine produced and excreted" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0004181 abnormal carotid artery morphology "malformation of any of the four arteries (two on each side of the neck; right and left internal carotid arteries, and right and left external carotid arteries) that deliver oxygen-rich blood from the heart to the head and brain" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0004183 abnormal sympathetic nervous system physiology "anomaly in the function of the part of the autonomic nervous system that innervates smooth muscle, cardiac muscle and glands and mediates the body s response to stressful situations" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ednrbtm1Ywa/Ednrb+
Genetic Background: involves: 129S/SvEvBrd

 MP:0004205 absent hyoid bone "absence of the U-shaped bone lying between the mandible and the larynx that supports the tongue muscles" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0004217 salt-sensitive hypertension "sustained high blood pressure that is maintained with a normal or increase in the amount of salt consumed in the diet; blood pressure may return to normotensive with a low salt diet" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0004486 decreased response of heart to induced stress "decrease in severity of the physiological response of the heart to induced stress such as cardiac hypertrophy due to mechanical pressure overload from aortic banding" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: GckGena348/GckGena348
Genetic Background: involves: BALB/c * C3H/He

 MP:0004875 increased mean arterial blood pressure "increase in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ednrbtm1Ywa/Ednrb+
Genetic Background: involves: 129S/SvEvBrd

 MP:0004876 decreased mean arterial blood pressure "decrease in the average arterial pressure during a single cardiac cycle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0005039 hypoxia "reduced concentration of O2 in the blood, alveoli or other tissues resulting in the decreased pressure of this component of body gases" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ednrbtm1Ywa/Ednrb+
Genetic Background: involves: 129S/SvEvBrd

 MP:0005579 absent outer ear "missing auricles or external acoustic meatus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:17694]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0005611 decreased circulating antidiuretic hormone level "less than the normal concentration of this peptide hormone in the blood; it is normally released by the neurohypophysis to control water metabolism and balance by regulating water loss; it also contracts smooth muscle" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0005634 decreased circulating sodium level "less than the normal concentration in the blood of this metallic element, the most plentiful extracellular ion in the body and the principal determinant of extracellular fluid volume" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
Show

Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0006144 increased systolic blood pressure "abnormal increase in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pctptm1Bor/Pctptm1Bor
Genetic Background: involves: 129P2/OlaHsd * FVB/NJ

 MP:0006263 decreased diastolic blood pressure "abnormal decrease in the pressure in the arteries between heart beats when the heart is relaxed" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0006264 decreased systolic blood pressure "abnormal decrease in the pressure in the arteries as the heart contracts and pumps blood into the arteries" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator, J:21887]
Show

Allelic Composition: Mpzm1Anu/?
Genetic Background: involves: BALB/c * C57BL/6 * DBA/2

 MP:0006317 decreased urine sodium level "lower than normal concentration of sodium in the urine" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disp1icb/Disp1tm1Amc,Shhtm1(EGFP/cre)Cjt/Shh+
Genetic Background: involves: 129X1/SvJ * C57BL/6J

 MP:0006337 abnormal first branchial arch morphology "anomaly in the structure of the first arch which contributes to development of mastication muscles, maxilla, mandible, incus, malleus, Meckel s cartilage, trigeminal nerve, and maxillary artery" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0006344 small second branchial arch "reduced size of the second branchial arch" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0006354 abnormal fourth branchial arch artery morphology "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0008055 increased urine osmolality "increase in the concentration of ions in the urine compared to the normal state" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0009524 absent submandibular gland "absence of either of the large major salivary glands situated beneath the mandible" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

 MP:0009643 abnormal urine homeostasis "anomaly in the processes involved in the maintenance of an internal equilibrium of various functions and chemical or protein composition of the urine" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Disc1del/Disc1del
Genetic Background: B6.129S6-Disc1del

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0010486 absent right subclavian artery "absence of one of the two subclavian arteries; the right subclavian artery normally extends from the brachiocephalic artery to the right side of the body" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0010543 aorta tubular hypoplasia "a diffuse narrowing of the lumen of the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0010544 interrupted aorta "complete discontinuation or blockage in the aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Syt1tm6Sud/Syt1tm6Sud
Genetic Background: Not Specified

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Slc14a2tm1Suc/Slc14a2tm1Suc
Genetic Background: involves: 129S2/SvPas * C57BL/6J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: EdaTa/Eda+
Genetic Background: involves: A * C57BL * CBA * RIII

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000031616 Ednra / Q61614 / Endothelin-1 receptor / P25101* / endothelin receptor type A*  / complex / reaction
 ENSMUSG00000022122 Ednrb / P48302 / Endothelin receptor type B / P24530*  / reaction / complex
 ENSMUSG00000057530 Ece1 / Q4PZA2 / Endothelin-converting enzyme 1 / P42892*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr