ENSGALG00000012735


Gallus gallus

Features
Gene ID: ENSGALG00000012735
  
Biological name :EDN1
  
Synonyms : EDN1 / endothelin 1
  
Possible biological names infered from orthology : Endothelin-1 Big endothelin-1 / P05305 / P22387
  
Species: Gallus gallus
  
Chr. number: 2
Strand: -1
Band:
Gene start: 62884522
Gene end: 62888112
  
Corresponding Affymetrix probe sets: GgaAffx.8070.1.S1_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000020756
NCBI entrez gene - 420854     See in Manteia.
RefSeq - XM_418943
swissprot - F1NWA9
Ensembl - ENSGALG00000012735
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 edn1ENSDARG00000036912Danio rerio
 EDN1ENSG00000078401Homo sapiens
 Edn1ENSMUSG00000021367Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EDN2 / endothelin 2 / P20800* / P22389*ENSGALG0000000066724
EDN3 / endothelin 3 / P14138* / P48299*ENSGALG0000004088022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001928  Endothelin-like toxin
 IPR019764  Endothelin-like toxin, conserved site
 IPR020475  Endothelin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001501 skeletal system development IEA
 biological_processGO:0001516 prostaglandin biosynthetic process IEA
 biological_processGO:0001569 branching involved in blood vessel morphogenesis IEA
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0003100 regulation of systemic arterial blood pressure by endothelin IEA
 biological_processGO:0006885 regulation of pH IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0007585 respiratory gaseous exchange IEA
 biological_processGO:0007589 body fluid secretion IEA
 biological_processGO:0008217 regulation of blood pressure IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IEA
 biological_processGO:0010460 positive regulation of heart rate IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010613 positive regulation of cardiac muscle hypertrophy IEA
 biological_processGO:0010870 positive regulation of receptor biosynthetic process IEA
 biological_processGO:0014032 neural crest cell development IEA
 biological_processGO:0014065 phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014824 artery smooth muscle contraction IEA
 biological_processGO:0014826 vein smooth muscle contraction IEA
 biological_processGO:0019229 regulation of vasoconstriction IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0030072 peptide hormone secretion IEA
 biological_processGO:0030185 nitric oxide transport IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0031583 phospholipase D-activating G-protein coupled receptor signaling pathway IEA
 biological_processGO:0032269 negative regulation of cellular protein metabolic process IEA
 biological_processGO:0035810 positive regulation of urine volume IEA
 biological_processGO:0035815 positive regulation of renal sodium excretion IEA
 biological_processGO:0042310 vasoconstriction IEA
 biological_processGO:0042313 protein kinase C deactivation IEA
 biological_processGO:0042474 middle ear morphogenesis IEA
 biological_processGO:0043179 rhythmic excitation IEA
 biological_processGO:0043406 positive regulation of MAP kinase activity IEA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0045793 positive regulation of cell size IEA
 biological_processGO:0045840 positive regulation of mitotic nuclear division IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046887 positive regulation of hormone secretion IEA
 biological_processGO:0048016 inositol phosphate-mediated signaling IEA
 biological_processGO:0048514 blood vessel morphogenesis IEA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway IEA
 biological_processGO:0051771 negative regulation of nitric-oxide synthase biosynthetic process IEA
 biological_processGO:0060298 positive regulation of sarcomere organization IEA
 biological_processGO:0060585 positive regulation of prostaglandin-endoperoxide synthase activity IEA
 biological_processGO:0061051 positive regulation of cell growth involved in cardiac muscle cell development IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005179 hormone activity IEA
 molecular_functionGO:0031707 endothelin A receptor binding IEA
 molecular_functionGO:0031708 endothelin B receptor binding IEA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (q) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000010013 EDNRA / endothelin receptor type A / P25101* / Q61614* / Endothelin-1 receptor *  / complex / reaction
 ENSGALG00000016912 EDNRB / endothelin receptor type B / P24530* / P48302*  / complex / reaction
 ENSGALG00000031343 ECE1 / endothelin converting enzyme 1 / P42892* / Q4PZA2*  / reaction






 

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