ENSG00000129932


Homo sapiens

Features
Gene ID: ENSG00000129932
  
Biological name :DOHH
  
Synonyms : deoxyhypusine hydroxylase / DOHH / Q9BU89
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.3
Gene start: 3490822
Gene end: 3500940
  
Corresponding Affymetrix probe sets: 208141_s_at (Human Genome U133 Plus 2.0 Array)   213949_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398882
NCBI entrez gene - 83475     See in Manteia.
OMIM - 611262
RefSeq - NM_031304
RefSeq - NM_001145165
RefSeq Peptide - NP_001138637
RefSeq Peptide - NP_112594
swissprot - Q9BU89
Ensembl - ENSG00000129932
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dohhENSDARG00000003564Danio rerio
 DOHHENSGALG00000017524Gallus gallus
 DohhENSMUSG00000078440Mus musculus
 Q99LN9ENSMUSG00000113262Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR004155  PBS lyase HEAT-like repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR021133  HEAT, type 2
 IPR027517  Deoxyhypusine hydroxylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019135 deoxyhypusine monooxygenase activity EXP
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Hypusine synthesis from eIF5A-lysine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000163577 EIF5A2 / Q9GZV4 / eukaryotic translation initiation factor 5A2  / reaction
 ENSG00000132507 EIF5A / P63241 / eukaryotic translation initiation factor 5A  / reaction






 

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