ENSG00000163577


Homo sapiens

Features
Gene ID: ENSG00000163577
  
Biological name :EIF5A2
  
Synonyms : EIF5A2 / eukaryotic translation initiation factor 5A2 / Q9GZV4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: q26.2
Gene start: 170888415
Gene end: 170908693
  
Corresponding Affymetrix probe sets: 220198_s_at (Human Genome U133 Plus 2.0 Array)   235289_at (Human Genome U133 Plus 2.0 Array)   235296_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000295822
Ensembl peptide - ENSP00000418370
Ensembl peptide - ENSP00000418305
Ensembl peptide - ENSP00000417133
NCBI entrez gene - 56648     See in Manteia.
OMIM - 605782
RefSeq - NM_020390
RefSeq Peptide - NP_065123
swissprot - Q9GZV4
swissprot - F8WCJ1
swissprot - C9J4W5
swissprot - C9J7B5
Ensembl - ENSG00000163577
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif5aENSDARG00000017235Danio rerio
 EIF5A2ENSGALG00000009309Gallus gallus
 Eif5a2ENSMUSG00000050192Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EIF5A / P63241 / eukaryotic translation initiation factor 5AENSG0000013250782
Q6IS14 / EIF5AL1 / eukaryotic translation initiation factor 5A-like 1ENSG0000025362680


Protein motifs (from Interpro)
Interpro ID Name
 IPR001884  Translation elongation factor IF5A-like
 IPR008991  Translation protein SH3-like domain superfamily
 IPR012340  Nucleic acid-binding, OB-fold
 IPR014722  Ribosomal protein L2, domain 2
 IPR019769  Translation elongation factor, IF5A, hypusine site
 IPR020189  Translation elongation factor, IF5A C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation IEA
 biological_processGO:0006414 translational elongation IEA
 biological_processGO:0006452 translational frameshifting IEA
 biological_processGO:0007283 spermatogenesis NAS
 biological_processGO:0008284 positive regulation of cell proliferation IGI
 biological_processGO:0008612 peptidyl-lysine modification to peptidyl-hypusine TAS
 biological_processGO:0010509 polyamine homeostasis NAS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0045901 positive regulation of translational elongation IEA
 biological_processGO:0045905 positive regulation of translational termination IEA
 biological_processGO:0051028 mRNA transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003723 RNA binding IEA
 molecular_functionGO:0003746 translation elongation factor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0043022 ribosome binding IEA


Pathways (from Reactome)
Pathway description
Hypusine synthesis from eIF5A-lysine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000095059 DHPS / P49366 / deoxyhypusine synthase  / reaction
 ENSG00000129932 DOHH / Q9BU89 / deoxyhypusine hydroxylase  / reaction






 

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