ENSG00000095059


Homo sapiens

Features
Gene ID: ENSG00000095059
  
Biological name :DHPS
  
Synonyms : deoxyhypusine synthase / DHPS / P49366
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.13
Gene start: 12675717
Gene end: 12681902
  
Corresponding Affymetrix probe sets: 202802_at (Human Genome U133 Plus 2.0 Array)   207831_x_at (Human Genome U133 Plus 2.0 Array)   211558_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000472094
Ensembl peptide - ENSP00000482709
Ensembl peptide - ENSP00000472348
Ensembl peptide - ENSP00000472330
Ensembl peptide - ENSP00000472122
Ensembl peptide - ENSP00000472096
Ensembl peptide - ENSP00000210060
Ensembl peptide - ENSP00000221303
Ensembl peptide - ENSP00000468889
Ensembl peptide - ENSP00000468993
Ensembl peptide - ENSP00000469366
Ensembl peptide - ENSP00000470188
Ensembl peptide - ENSP00000470754
Ensembl peptide - ENSP00000471280
Ensembl peptide - ENSP00000471466
Ensembl peptide - ENSP00000471886
NCBI entrez gene - 1725     See in Manteia.
OMIM - 600944
RefSeq - NM_013406
RefSeq - NM_001930
RefSeq - NM_001206974
RefSeq - XM_011527770
RefSeq - XM_011527771
RefSeq Peptide - NP_001921
RefSeq Peptide - NP_037538
RefSeq Peptide - NP_001193903
swissprot - M0R0V2
swissprot - M0R1T2
swissprot - B4E3M2
swissprot - M0R253
swissprot - M0R264
swissprot - P49366
swissprot - Q5J8M5
swissprot - M0R1T4
swissprot - A0A087WZK0
swissprot - A0A024R7E9
swissprot - A0A024R7D0
swissprot - M0QX43
swissprot - M0QXT2
swissprot - M0QYZ7
swissprot - M0QZT3
swissprot - M0R0J4
Ensembl - ENSG00000095059
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhpsENSDARG00000003270Danio rerio
 DhpsENSMUSG00000060038Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002773  Deoxyhypusine synthase
 IPR029035  DHS-like NAD/FAD-binding domain superfamily
 IPR036982  Deoxyhypusine synthase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006412 translation TAS
 biological_processGO:0008216 spermidine metabolic process IDA
 biological_processGO:0008284 positive regulation of cell proliferation TAS
 biological_processGO:0008612 peptidyl-lysine modification to peptidyl-hypusine IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042593 glucose homeostasis IEA
 biological_processGO:0046203 spermidine catabolic process IEA
 biological_processGO:0051289 protein homotetramerization IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034038 deoxyhypusine synthase activity EXP
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Hypusine synthesis from eIF5A-lysine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000095059 DHPS / P49366 / deoxyhypusine synthase  / complex
 ENSG00000132507 EIF5A / P63241 / eukaryotic translation initiation factor 5A  / reaction
 ENSG00000163577 EIF5A2 / Q9GZV4 / eukaryotic translation initiation factor 5A2  / reaction






 

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