ENSMUSG00000060038


Mus musculus

Features
Gene ID: ENSMUSG00000060038
  
Biological name :Dhps
  
Synonyms : Deoxyhypusine synthase / Dhps / Q3TXU5
  
Possible biological names infered from orthology : P49366
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C3
Gene start: 85071757
Gene end: 85075162
  
Corresponding Affymetrix probe sets: 10573566 (MoGene1.0st)   1434003_a_at (Mouse Genome 430 2.0 Array)   1434004_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000077733
Ensembl peptide - ENSMUSP00000120308
NCBI entrez gene - 330817     See in Manteia.
MGI - MGI:2683592
RefSeq - NM_001039514
RefSeq - XM_011248416
RefSeq Peptide - NP_001034603
swissprot - F6W7I2
swissprot - Q3TXU5
Ensembl - ENSMUSG00000060038
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dhpsENSDARG00000003270Danio rerio
 DHPSENSG00000095059Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002773  Deoxyhypusine synthase
 IPR029035  DHS-like NAD/FAD-binding domain superfamily
 IPR036982  Deoxyhypusine synthase superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008216 spermidine metabolic process IEA
 biological_processGO:0008612 peptidyl-lysine modification to peptidyl-hypusine IEA
 biological_processGO:0042102 positive regulation of T cell proliferation IMP
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0046203 spermidine catabolic process IEA
 biological_processGO:0051289 protein homotetramerization IEA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0034038 deoxyhypusine synthase activity IBA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Hypusine synthesis from eIF5A-lysine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000333 decreased bone marrow cell number "decreased number of cells that make up the core cavities of bones when compared to the norm" [tc:Teresa Chu , Mouse Genome Informatics Curator, J:60896]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0000694 spleen hypoplasia "small size due to reduced cell number in the spleen" [J:43971]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Nexntm1.1Zhh/Nexn+
Genetic Background: involves: C57BL/6NTac

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0008477 decreased spleen red pulp amount "reduction in the quantity of the parenchymatous tissue network of the spleen that consists of loose plates or cords (sinuses) infiltrated with red blood cells where most of the blood filtration occurs and degenerate erythrocytes are removed from the circulation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0011091 complete prenatal lethality "death of all organisms of a given genotype in a population between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Nexntm1.1Zhh/Nexn+
Genetic Background: involves: C57BL/6NTac

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Dbn1tm1b(KOMP)Wtsi/Dbn1+
Genetic Background: C57BL/6N-Dbn1tm1b(KOMP)Wtsi/Bay

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060038 Dhps / Q3TXU5 / Deoxyhypusine synthase / P49366*  / complex
 ENSMUSG00000078812 Eif5a / P63242 / Eukaryotic translation initiation factor 5A-1 / P63241* / Q6IS14* / EIF5AL1* / eukaryotic translation initiation factor 5A* / eukaryotic translation initiation factor 5A-like 1*  / reaction
 ENSMUSG00000050192 Eif5a2 / Q8BGY2 / Eukaryotic translation initiation factor 5A-2 / Q9GZV4*  / reaction






 

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