ENSMUSG00000078812


Mus musculus

Features
Gene ID: ENSMUSG00000078812
  
Biological name :Eif5a
  
Synonyms : Eif5a / Eukaryotic translation initiation factor 5A-1 / P63242
  
Possible biological names infered from orthology : EIF5AL1 / eukaryotic translation initiation factor 5A / eukaryotic translation initiation factor 5A-like 1 / P63241 / Q6IS14
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: B3
Gene start: 69916714
Gene end: 69921958
  
Corresponding Affymetrix probe sets: 10387733 (MoGene1.0st)   10523058 (MoGene1.0st)   1437859_x_at (Mouse Genome 430 2.0 Array)   1451470_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000137459
Ensembl peptide - ENSMUSP00000123402
Ensembl peptide - ENSMUSP00000132717
Ensembl peptide - ENSMUSP00000047008
Ensembl peptide - ENSMUSP00000067077
Ensembl peptide - ENSMUSP00000068651
Ensembl peptide - ENSMUSP00000104247
Ensembl peptide - ENSMUSP00000104248
Ensembl peptide - ENSMUSP00000104249
Ensembl peptide - ENSMUSP00000104250
Ensembl peptide - ENSMUSP00000104251
Ensembl peptide - ENSMUSP00000104252
Ensembl peptide - ENSMUSP00000104253
NCBI entrez gene - 276770     See in Manteia.
MGI - MGI:106248
RefSeq - XM_011249058
RefSeq - NM_001166589
RefSeq - NM_001166590
RefSeq - NM_001166591
RefSeq - NM_001166592
RefSeq - NM_001166593
RefSeq - NM_001166594
RefSeq - NM_001166595
RefSeq - NM_001166596
RefSeq - NM_181582
RefSeq Peptide - NP_001160068
RefSeq Peptide - NP_853613
RefSeq Peptide - NP_001160062
RefSeq Peptide - NP_001160061
RefSeq Peptide - NP_001160063
RefSeq Peptide - NP_001160064
RefSeq Peptide - NP_001160065
RefSeq Peptide - NP_001160066
RefSeq Peptide - NP_001160067
swissprot - P63242
swissprot - J3QPS8
swissprot - A0A0A0MQM0
Ensembl - ENSMUSG00000078812
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eif5aENSDARG00000017235Danio rerio
 EIF5AENSG00000132507Homo sapiens
 Q6IS14ENSG00000253626Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eif5a2 / Q8BGY2 / Eukaryotic translation initiation factor 5A-2 / Q9GZV4*ENSMUSG0000005019282


Protein motifs (from Interpro)
Interpro ID Name
 IPR001884  Translation elongation factor IF5A-like
 IPR008991  Translation protein SH3-like domain superfamily
 IPR012340  Nucleic acid-binding, OB-fold
 IPR014722  Ribosomal protein L2, domain 2
 IPR019769  Translation elongation factor, IF5A, hypusine site
 IPR020189  Translation elongation factor, IF5A C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006406 mRNA export from nucleus ISO
 biological_processGO:0006412 translation IEA
 biological_processGO:0006414 translational elongation IEA
 biological_processGO:0006452 translational frameshifting IEA
 biological_processGO:0006611 protein export from nucleus ISO
 biological_processGO:0006915 apoptotic process ISO
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation ISO
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043065 positive regulation of apoptotic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0045901 positive regulation of translational elongation IEA
 biological_processGO:0045905 positive regulation of translational termination IEA
 biological_processGO:0051028 mRNA transport IEA
 biological_processGO:0051149 positive regulation of muscle cell differentiation IEA
 biological_processGO:0097067 cellular response to thyroid hormone stimulus IEA
 biological_processGO:2000379 positive regulation of reactive oxygen species metabolic process IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005642 annulate lamellae ISO
 cellular_componentGO:0005643 nuclear pore IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 molecular_functionGO:0003723 RNA binding ISO
 molecular_functionGO:0003746 translation elongation factor activity IEA
 molecular_functionGO:0017070 U6 snRNA binding ISO
 molecular_functionGO:0043022 ribosome binding IEA
 molecular_functionGO:0047485 protein N-terminus binding ISO


Pathways (from Reactome)
Pathway description
Hypusine synthesis from eIF5A-lysine


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078440 Dohh / Q99LN9 / Deoxyhypusine hydroxylase / Q9BU89*  / reaction
 ENSMUSG00000060038 Dhps / Q3TXU5 / Deoxyhypusine synthase / P49366*  / reaction






 

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