ENSMUSG00000078440


Mus musculus

Features
Gene ID: ENSMUSG00000078440
  
Biological name :Dohh
  
Synonyms : Deoxyhypusine hydroxylase / Dohh / Q99LN9
  
Possible biological names infered from orthology : Q9BU89
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: C1
Gene start: 81384428
Gene end: 81388352
  
Corresponding Affymetrix probe sets: 10365116 (MoGene1.0st)   1417322_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072534
Ensembl peptide - ENSMUSP00000122952
Ensembl peptide - ENSMUSP00000120386
Ensembl peptide - ENSMUSP00000113112
NCBI entrez gene - 102115     See in Manteia.
MGI - MGI:1915964
RefSeq - NM_133964
RefSeq Peptide - NP_598725
swissprot - D3Z6Y9
swissprot - D3YZM0
swissprot - D3Z7J7
swissprot - Q99LN9
Ensembl - ENSMUSG00000078440
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dohhENSDARG00000003564Danio rerio
 DOHHENSGALG00000017524Gallus gallus
 DOHHENSG00000129932Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Q99LN9 / Gm48551 / predicted gene, 48551 / DOHH* / Q9BU89* / deoxyhypusine hydroxylase*ENSMUSG0000011326243


Protein motifs (from Interpro)
Interpro ID Name
 IPR004155  PBS lyase HEAT-like repeat
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold
 IPR027517  Deoxyhypusine hydroxylase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008612 peptidyl-lysine modification to peptidyl-hypusine ISO
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0004497 monooxygenase activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0019135 deoxyhypusine monooxygenase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0001656 focal hepatic necrosis "a localized area of pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0004154 renal tubular necrosis "pathological cell death in the proximal and/or distal renal tubules, usually due to irreversible damage " [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0005150 cachexia "general weight loss and wasting occurring in the course of chronic disease" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0010375 increased kidney iron level "increase in the amount of iron present in the renal tissue" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Grk1tvrm207/Grk1tvrm207
Genetic Background: B6.Cg-Grk1tvrm207/Pjn

 MP:0013292 embryonic lethality prior to organogenesis "death prior to the completion of embryo turning (Mus: E9-9.5)" [MGI:smb]
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Allelic Composition: Clcn2tm2.1Tjj/Clcn2tm2.1Tjj,Hepacamtm1.2Tjj/Hepacamtm1.2Tjj
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6NTac

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000078812 Eif5a / P63242 / Eukaryotic translation initiation factor 5A-1 / P63241* / Q6IS14* / EIF5AL1* / eukaryotic translation initiation factor 5A* / eukaryotic translation initiation factor 5A-like 1*  / reaction
 ENSMUSG00000050192 Eif5a2 / Q8BGY2 / Eukaryotic translation initiation factor 5A-2 / Q9GZV4*  / reaction






 

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