ENSG00000131037


Homo sapiens

Features
Gene ID: ENSG00000131037
  
Biological name :EPS8L1
  
Synonyms : EPS8L1 / EPS8 like 1 / Q8TE68
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: q13.42
Gene start: 55072020
Gene end: 55087923
  
Corresponding Affymetrix probe sets: 218778_x_at (Human Genome U133 Plus 2.0 Array)   218779_x_at (Human Genome U133 Plus 2.0 Array)   221655_x_at (Human Genome U133 Plus 2.0 Array)   221665_s_at (Human Genome U133 Plus 2.0 Array)   91826_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000466245
Ensembl peptide - ENSP00000465830
Ensembl peptide - ENSP00000466828
Ensembl peptide - ENSP00000201647
Ensembl peptide - ENSP00000245618
Ensembl peptide - ENSP00000437541
NCBI entrez gene - 54869     See in Manteia.
OMIM - 614987
RefSeq - XM_011527052
RefSeq - NM_017729
RefSeq - NM_133180
RefSeq - XM_005259020
RefSeq - XM_011527050
RefSeq - XM_011527051
RefSeq Peptide - NP_060199
RefSeq Peptide - NP_573441
swissprot - K7EKX9
swissprot - K7ELW3
swissprot - K7EN83
swissprot - Q8TE68
swissprot - B4DKV7
Ensembl - ENSG00000131037
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eps8l1ENSDARG00000057984Danio rerio
 si:ch73-70c5.1ENSDARG00000003313Danio rerio
 Eps8l1ENSMUSG00000006154Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EPS8 / Q12929 / epidermal growth factor receptor pathway substrate 8ENSG0000015149138
EPS8L2 / Q9H6S3 / EPS8 like 2ENSG0000017710638
EPS8L3 / Q8TE67 / EPS8 like 3ENSG0000019875825


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR033928  Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain
 IPR035462  Eps8, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007266 Rho protein signal transduction IDA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IDA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900029 positive regulation of ruffle assembly IGI
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0032587 ruffle membrane IDA
 cellular_componentGO:0032991 protein-containing complex IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IDA
 molecular_functionGO:0042608 T cell receptor binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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