ENSMUSG00000006154


Mus musculus

Features
Gene ID: ENSMUSG00000006154
  
Biological name :Eps8l1
  
Synonyms : Epidermal growth factor receptor kinase substrate 8-like protein 1 / Eps8l1 / Q8R5F8
  
Possible biological names infered from orthology : EPS8 like 1 / Q8TE68
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: A1
Gene start: 4460674
Gene end: 4480487
  
Corresponding Affymetrix probe sets: 10549655 (MoGene1.0st)   1431821_a_at (Mouse Genome 430 2.0 Array)   1450470_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000126720
Ensembl peptide - ENSMUSP00000133206
Ensembl peptide - ENSMUSP00000133142
Ensembl peptide - ENSMUSP00000133102
Ensembl peptide - ENSMUSP00000131773
Ensembl peptide - ENSMUSP00000131345
Ensembl peptide - ENSMUSP00000130665
Ensembl peptide - ENSMUSP00000127999
Ensembl peptide - ENSMUSP00000083559
Ensembl peptide - ENSMUSP00000125840
NCBI entrez gene - 67425     See in Manteia.
MGI - MGI:1914675
RefSeq - XM_017312258
RefSeq - NM_001290416
RefSeq - NM_026146
RefSeq - XM_006540323
RefSeq - XM_006540324
RefSeq - XM_006540325
RefSeq - XM_006540326
RefSeq Peptide - NP_001277345
RefSeq Peptide - NP_080422
swissprot - E9Q4X5
swissprot - E9PZ95
swissprot - E9PWX4
swissprot - E9PVI7
swissprot - E9PV32
swissprot - E9PV13
swissprot - E9Q2P3
swissprot - F7BBD2
swissprot - Q8R5F8
Ensembl - ENSMUSG00000006154
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eps8l1ENSDARG00000057984Danio rerio
 si:ch73-70c5.1ENSDARG00000003313Danio rerio
 EPS8L1ENSG00000131037Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eps8 / Q08509 / Epidermal growth factor receptor kinase substrate 8 / Q12929* / epidermal growth factor receptor pathway substrate 8*ENSMUSG0000001576640
Eps8l2 / Q99K30 / Epidermal growth factor receptor kinase substrate 8-like protein 2 / Q9H6S3* / EPS8 like 2*ENSMUSG0000002550439
Eps8l3 / Q91WL0 / Epidermal growth factor receptor kinase substrate 8-like protein 3 / Q8TE67* / EPS8 like 3*ENSMUSG0000004060024


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR033928  Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain
 IPR035462  Eps8, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007266 Rho protein signal transduction IEA
 biological_processGO:0016601 Rac protein signal transduction ISA
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:1900029 positive regulation of ruffle assembly IEA
 cellular_componentGO:0001726 ruffle ISA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0032991 protein-containing complex IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0030676 Rac guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0042608 T cell receptor binding IEA
 molecular_functionGO:0045296 cadherin binding IEA
 molecular_functionGO:0051015 actin filament binding ISA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0011967 increased or absent threshold for auditory brainstem response "increase in the value at which one or more sound frequencies or broadband clicks first elicits a recordable response generated by electrical activity of neurons in the ascending auditory system, or complete lack of a recordable response at any frequency or broadband click" [MGI:csmith]
Show

Allelic Composition: Dixdc1tm1.1(KOMP)Vlcg/Dixdc1tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Dixdc1tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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