ENSMUSG00000015766


Mus musculus

Features
Gene ID: ENSMUSG00000015766
  
Biological name :Eps8
  
Synonyms : Epidermal growth factor receptor kinase substrate 8 / Eps8 / Q08509
  
Possible biological names infered from orthology : epidermal growth factor receptor pathway substrate 8 / Q12929
  
Species: Mus musculus
  
Chr. number: 6
Strand: -1
Band: G1
Gene start: 137477245
Gene end: 137654876
  
Corresponding Affymetrix probe sets: 10548905 (MoGene1.0st)   1422823_at (Mouse Genome 430 2.0 Array)   1422824_s_at (Mouse Genome 430 2.0 Array)   1425733_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120044
Ensembl peptide - ENSMUSP00000119997
Ensembl peptide - ENSMUSP00000120648
Ensembl peptide - ENSMUSP00000145059
Ensembl peptide - ENSMUSP00000122517
Ensembl peptide - ENSMUSP00000052776
Ensembl peptide - ENSMUSP00000098402
Ensembl peptide - ENSMUSP00000107509
NCBI entrez gene - 13860     See in Manteia.
MGI - MGI:104684
RefSeq - XM_017321383
RefSeq - NM_001271587
RefSeq - NM_001271588
RefSeq - NM_001271589
RefSeq - NM_001271595
RefSeq - NM_007945
RefSeq - XM_006505508
RefSeq - XM_011241204
RefSeq Peptide - NP_001258518
RefSeq Peptide - NP_001258524
RefSeq Peptide - NP_031971
RefSeq Peptide - NP_001258516
RefSeq Peptide - NP_001258517
swissprot - A0A0N4SVD8
swissprot - Q3UGL1
swissprot - D3Z7F4
swissprot - D3Z5I5
swissprot - D3YXC3
swissprot - Q08509
Ensembl - ENSMUSG00000015766
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eps8ENSDARG00000102128Danio rerio
 ENSGALG00000013091Gallus gallus
 EPS8ENSG00000151491Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Eps8l2 / Q99K30 / Epidermal growth factor receptor kinase substrate 8-like protein 2 / Q9H6S3* / EPS8 like 2*ENSMUSG0000002550438
Eps8l1 / Q8R5F8 / Epidermal growth factor receptor kinase substrate 8-like protein 1 / Q8TE68* / EPS8 like 1*ENSMUSG0000000615435
Eps8l3 / Q91WL0 / Epidermal growth factor receptor kinase substrate 8-like protein 3 / Q8TE67* / EPS8 like 3*ENSMUSG0000004060022


Protein motifs (from Interpro)
Interpro ID Name
 IPR001452  SH3 domain
 IPR006020  PTB/PI domain
 IPR011993  PH-like domain superfamily
 IPR013625  Tensin/EPS8 phosphotyrosine-binding domain
 IPR030222  Epidermal growth factor receptor kinase substrate 8
 IPR033928  Epidermal growth factor receptor kinase substrate, phosphotyrosine-binding domain
 IPR035462  Eps8, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008344 adult locomotory behavior IMP
 biological_processGO:0008360 regulation of cell shape IMP
 biological_processGO:0009967 positive regulation of signal transduction IEA
 biological_processGO:0010458 exit from mitosis IMP
 biological_processGO:0016601 Rac protein signal transduction IDA
 biological_processGO:0030832 regulation of actin filament length IMP
 biological_processGO:0031532 actin cytoskeleton reorganization IMP
 biological_processGO:0036336 dendritic cell migration IMP
 biological_processGO:0048149 behavioral response to ethanol IMP
 biological_processGO:0051016 barbed-end actin filament capping IEA
 biological_processGO:0051017 actin filament bundle assembly IEA
 biological_processGO:0051764 actin crosslink formation IMP
 biological_processGO:0070358 actin polymerization-dependent cell motility IDA
 biological_processGO:1990830 cellular response to leukemia inhibitory factor IEP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005903 brush border IDA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0014069 postsynaptic density IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0017146 NMDA selective glutamate receptor complex IDA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0032420 stereocilium IEA
 cellular_componentGO:0032421 stereocilium bundle IDA
 cellular_componentGO:0032426 stereocilium tip IDA
 cellular_componentGO:0032587 ruffle membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0035591 signaling adaptor activity IEA
 molecular_functionGO:0048365 Rac GTPase binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001987 alcohol preference 
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Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002066 abnormal motor capabilities/coordination/movement "altered ability to coordinate voluntary movement or repetitive, compulsive movements" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002863 improved righting response "faster ability or less amount of time needed to recover from supine position" [J:86936]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0002910 abnormal excitatory postsynaptic currents "defect in the size or duration of currents detected in postsynaptic cells when an excitatory impulse arrives at the synapse causing depolarization" [Principles of Neural Science , 3rd edition:ISBN 0-8385-8034-3]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003234 enhanced NMDA-mediated synaptic currents "increase in the measured amplitude or duration of response to stimulation of NMDA receptors" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

 MP:0004521 abnormal cochlear hair cell stereociliary bundle morphology "any structural anomaly or disruption of the typical pattern of arrangement of mechanosensitive hair bundles which are composed of thick long microvilli (stereocilia) and are located at the apical end of cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Map2repro4/Map2repro4
Genetic Background: C3.B6-Map2repro4

 MP:0004524 short cochlear hair cell stereocilia "reduced length of the nonmotile, actin-filled specialized microvilli (stereocilia) which are normally arrayed on cochlear inner and outer hair cells" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Eps8tm1Ppdf/Eps8tm1Ppdf,Eps8l2tm1Wma/Eps8l2tm1Wma
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdkn2atm4Rdp/Cdkn2a+,Krastm4Tyj/Kras+,Ptf1atm1.1(cre)Cvw/Ptf1a+
Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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