ENSG00000135250


Homo sapiens

Features
Gene ID: ENSG00000135250
  
Biological name :SRPK2
  
Synonyms : P78362 / SRPK2 / SRSF protein kinase 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: -1
Band: q22.3
Gene start: 105110704
Gene end: 105399308
  
Corresponding Affymetrix probe sets: 1558254_s_at (Human Genome U133 Plus 2.0 Array)   203181_x_at (Human Genome U133 Plus 2.0 Array)   203182_s_at (Human Genome U133 Plus 2.0 Array)   214931_s_at (Human Genome U133 Plus 2.0 Array)   217517_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000418786
Ensembl peptide - ENSP00000417946
Ensembl peptide - ENSP00000419240
Ensembl peptide - ENSP00000420208
Ensembl peptide - ENSP00000419791
Ensembl peptide - ENSP00000349863
Ensembl peptide - ENSP00000377262
Ensembl peptide - ENSP00000417357
Ensembl peptide - ENSP00000417446
NCBI entrez gene - 6733     See in Manteia.
OMIM - 602980
RefSeq - XM_017012566
RefSeq - NM_001350742
RefSeq - NM_182691
RefSeq - NM_182692
RefSeq - XM_005250549
RefSeq - XM_005250550
RefSeq - XM_005250551
RefSeq - XM_006716098
RefSeq - XM_011516536
RefSeq - XM_011516538
RefSeq - XM_017012560
RefSeq - XM_017012561
RefSeq - XM_017012562
RefSeq - XM_017012563
RefSeq - XM_017012564
RefSeq - XM_017012565
RefSeq - NM_001278273
RefSeq - NM_001350738
RefSeq - NM_001350739
RefSeq - NM_001350740
RefSeq Peptide - NP_001337667
RefSeq Peptide - NP_001337668
RefSeq Peptide - NP_001337669
RefSeq Peptide - NP_001337671
RefSeq Peptide - NP_872633
RefSeq Peptide - NP_872634
RefSeq Peptide - NP_001265202
swissprot - C9JWF7
swissprot - P78362
swissprot - C9J2M4
swissprot - F8WAV6
swissprot - F8WBW4
swissprot - H7C521
swissprot - H7C5L6
swissprot - A0A024R704
Ensembl - ENSG00000135250
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01113818.1ENSDARG00000110142Danio rerio
 FP236318.1ENSDARG00000110485Danio rerio
 FP236318.2ENSDARG00000114874Danio rerio
 SRPK2ENSGALG00000008154Gallus gallus
 Srpk2ENSMUSG00000062604Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
SRPK1 / Q96SB4 / SRSF protein kinase 1ENSG0000009606356
SRPK3 / Q9UPE1 / SRSF protein kinase 3ENSG0000018434352


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000245 spliceosomal complex assembly IDA
 biological_processGO:0001525 angiogenesis ISS
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035063 nuclear speck organization ISS
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0043525 positive regulation of neuron apoptotic process ISS
 biological_processGO:0045070 positive regulation of viral genome replication IDA
 biological_processGO:0045071 negative regulation of viral genome replication IDA
 biological_processGO:0045087 innate immune response IC
 biological_processGO:0045787 positive regulation of cell cycle ISS
 biological_processGO:0048024 regulation of mRNA splicing, via spliceosome TAS
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0003723 RNA binding HDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0071889 14-3-3 protein binding ISS


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr