ENSMUSG00000062604


Mus musculus

Features
Gene ID: ENSMUSG00000062604
  
Biological name :Srpk2
  
Synonyms : serine/arginine-rich protein specific kinase 2 / Srpk2
  
Possible biological names infered from orthology : P78362 / SRSF protein kinase 2
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: A3
Gene start: 23503264
Gene end: 23684617
  
Corresponding Affymetrix probe sets: 10528484 (MoGene1.0st)   1417134_at (Mouse Genome 430 2.0 Array)   1417135_at (Mouse Genome 430 2.0 Array)   1417136_s_at (Mouse Genome 430 2.0 Array)   1431372_at (Mouse Genome 430 2.0 Array)   1435746_at (Mouse Genome 430 2.0 Array)   1448603_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000142494
Ensembl peptide - ENSMUSP00000085734
Ensembl peptide - ENSMUSP00000142554
Ensembl peptide - ENSMUSP00000143453
Ensembl peptide - ENSMUSP00000143216
Ensembl peptide - ENSMUSP00000142781
NCBI entrez gene - 20817     See in Manteia.
MGI - MGI:1201408
RefSeq - XM_017320777
RefSeq - XM_017320767
RefSeq - XM_017320768
RefSeq - XM_017320769
RefSeq - XM_017320770
RefSeq - XM_017320771
RefSeq - XM_017320772
RefSeq - XM_017320773
RefSeq - XM_017320774
RefSeq - XM_017320775
RefSeq - XM_017320776
RefSeq - NM_001359173
RefSeq - NM_001359174
RefSeq - NM_001359176
RefSeq - NM_009274
RefSeq - XM_006535660
RefSeq - XM_006535661
RefSeq - XM_011249751
RefSeq - XM_011249752
RefSeq - XM_011249753
RefSeq - XM_011249754
RefSeq - XM_011249755
RefSeq - XM_011249756
RefSeq - XM_011249757
RefSeq - XM_011249758
RefSeq - XM_011249759
RefSeq Peptide - NP_001346103
RefSeq Peptide - NP_001346105
RefSeq Peptide - NP_033300
RefSeq Peptide - NP_001346102
swissprot - A0A0G2JDT6
swissprot - A0A0R4J124
swissprot - Q6P5E1
swissprot - A0A0G2JG74
swissprot - A0A0G2JEI1
swissprot - A0A0G2JDY2
Ensembl - ENSMUSG00000062604
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01113818.1ENSDARG00000110142Danio rerio
 FP236318.1ENSDARG00000110485Danio rerio
 FP236318.2ENSDARG00000114874Danio rerio
 SRPK2ENSGALG00000008154Gallus gallus
 SRPK2ENSG00000135250Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srpk1 / O70551 / SRSF protein kinase 1 / Q96SB4*ENSMUSG0000000486556
Srpk3 / Q9Z0G2 / serine/arginine-rich protein specific kinase 3 / Q9UPE1* / SRSF protein kinase 3*ENSMUSG0000000200754


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000245 spliceosomal complex assembly IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008380 RNA splicing IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0045070 positive regulation of viral genome replication IEA
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IEA
 cellular_componentGO:0005730 nucleolus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IEA
 molecular_functionGO:0000287 magnesium ion binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000218 increased WBC count "greater than normal WBC numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

Allelic Composition: Lrrc17tm1Nik/Lrrc17+,Nf1tm1Par/Nf1tm1Par,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0001577 anemia "less than normal levels of red blood cells, hemoglobin or volume of packed red blood cells " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msh2tm2.2Rak/Msh2tm2.2Rak
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

Allelic Composition: Lrrc17tm1Nik/Lrrc17+,Nf1tm1Par/Nf1tm1Par,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Msh2tm2.2Rak/Msh2tm2.2Rak
Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

 MP:0002429 abnormal blood cell morphology/development "anomalous structure, differentiation, or number of any of the cells found in the blood" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Krastm4Tyj/Kras+,Lrrc17tm1Nik/Lrrc17+,Srpk2tm1Nik/Srpk2+,Tg(Mx1-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr