ENSMUSG00000002007


Mus musculus

Features
Gene ID: ENSMUSG00000002007
  
Biological name :Srpk3
  
Synonyms : Q9Z0G2 / serine/arginine-rich protein specific kinase 3 / Srpk3
  
Possible biological names infered from orthology : Q9UPE1 / SRSF protein kinase 3
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A7.3
Gene start: 73774405
Gene end: 73778925
  
Corresponding Affymetrix probe sets: 10600284 (MoGene1.0st)   1418798_s_at (Mouse Genome 430 2.0 Array)   1431825_at (Mouse Genome 430 2.0 Array)   1432139_at (Mouse Genome 430 2.0 Array)   1447806_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000002081
NCBI entrez gene - 56504     See in Manteia.
MGI - MGI:1891338
RefSeq - XM_006528172
RefSeq - NM_019684
RefSeq Peptide - NP_062658
swissprot - Q0VAW8
swissprot - Q9Z0G2
Ensembl - ENSMUSG00000002007
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 srpk3ENSDARG00000005916Danio rerio
 SRPK3ENSG00000184343Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Srpk2 / serine/arginine-rich protein specific kinase 2 / P78362* / SRSF protein kinase 2*ENSMUSG0000006260465
Srpk1 / O70551 / SRSF protein kinase 1 / Q96SB4*ENSMUSG0000000486559


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000245 spliceosomal complex assembly IBA
 biological_processGO:0006468 protein phosphorylation IDA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0007519 skeletal muscle tissue development IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0050684 regulation of mRNA processing IBA
 biological_processGO:0060537 muscle tissue development IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IDA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rpgrip1ltm1a(EUCOMM)Wtsi/Rpgrip1l+
Genetic Background: C57BL/6N-Rpgrip1ltm1a(EUCOMM)Wtsi/Wtsi

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mef2ctm1Eno/Mef2ctm1Jjs,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Srpk3tm1Eno/Y
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0004819 decreased skeletal muscle mass "reduction in the physical bulk, or total amount of matter contained within skeletal muscle" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mef2ctm1Eno/Mef2ctm1Jjs,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Srpk3tm1Eno/Y
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6J)

 MP:0009404 centrally nucleated skeletal muscle fibers "cell nuclei are located at a position in the center of the skeletal myofiber, instead of their normal location at the periphery of the fiber; may be indicative of centronuclear myopathy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mef2ctm1Eno/Mef2ctm1Jjs,Myl2tm1(cre)Krc/Myl2+
Genetic Background: involves: 129S4/SvJae * 129S6/SvEvTac * 129S7/SvEvBrd

Allelic Composition: Srpk3tm1Eno/Y
Genetic Background: either: (involves: 129S6/SvEvTac) or (involves: 129S6/SvEvTac * C57BL/6J)

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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