ENSG00000135838


Homo sapiens

Features
Gene ID: ENSG00000135838
  
Biological name :NPL
  
Synonyms : N-acetylneuraminate pyruvate lyase / NPL / Q9BXD5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q25.3
Gene start: 182789293
Gene end: 182830384
  
Corresponding Affymetrix probe sets: 221210_s_at (Human Genome U133 Plus 2.0 Array)   223405_at (Human Genome U133 Plus 2.0 Array)   240440_at (Human Genome U133 Plus 2.0 Array)   243066_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000356526
Ensembl peptide - ENSP00000356525
Ensembl peptide - ENSP00000482415
Ensembl peptide - ENSP00000258317
Ensembl peptide - ENSP00000356523
Ensembl peptide - ENSP00000356524
NCBI entrez gene - 80896     See in Manteia.
OMIM - 611412
RefSeq - NM_001200051
RefSeq - NM_001200050
RefSeq - NM_001200052
RefSeq - NM_001200056
RefSeq - NM_030769
RefSeq Peptide - NP_001186981
RefSeq Peptide - NP_001186979
RefSeq Peptide - NP_001186980
RefSeq Peptide - NP_001186985
RefSeq Peptide - NP_110396
swissprot - Q9BXD5
swissprot - A0A087WZ70
Ensembl - ENSG00000135838
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nplENSDARG00000009390Danio rerio
 NPLENSGALG00000004614Gallus gallus
 NplENSMUSG00000042684Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HOGA1 / Q86XE5 / 4-hydroxy-2-oxoglutarate aldolase 1ENSG0000024193524


Protein motifs (from Interpro)
Interpro ID Name
 IPR002220  DapA-like
 IPR005264  N-acetylneuraminate lyase
 IPR013785  Aldolase-type TIM barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0019262 N-acetylneuraminate catabolic process TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008747 N-acetylneuraminate lyase activity TAS
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
Sialic acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000135838 NPL / Q9BXD5 / N-acetylneuraminate pyruvate lyase  / complex






 

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