ENSMUSG00000042684


Mus musculus

Features
Gene ID: ENSMUSG00000042684
  
Biological name :Npl
  
Synonyms : N-acetylneuraminate lyase / Npl / Q9DCJ9
  
Possible biological names infered from orthology : N-acetylneuraminate pyruvate lyase / Q9BXD5
  
Species: Mus musculus
  
Chr. number: 1
Strand: -1
Band: G3
Gene start: 153503015
Gene end: 153550045
  
Corresponding Affymetrix probe sets: 10358879 (MoGene1.0st)   10358892 (MoGene1.0st)   1424265_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000037454
NCBI entrez gene - 74091     See in Manteia.
MGI - MGI:1921341
RefSeq - NM_028749
RefSeq Peptide - NP_083025
swissprot - Q9DCJ9
Ensembl - ENSMUSG00000042684
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nplENSDARG00000009390Danio rerio
 NPLENSGALG00000004614Gallus gallus
 NPLENSG00000135838Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hoga1 / Q9DCU9 / 4-hydroxy-2-oxoglutarate aldolase, mitochondrial / Q86XE5* / 4-hydroxy-2-oxoglutarate aldolase 1*ENSMUSG0000002517623


Protein motifs (from Interpro)
Interpro ID Name
 IPR002220  DapA-like
 IPR013785  Aldolase-type TIM barrel


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0005975 carbohydrate metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0019262 N-acetylneuraminate catabolic process TAS
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0008747 N-acetylneuraminate lyase activity ISO
 molecular_functionGO:0016829 lyase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA


Pathways (from Reactome)
Pathway description
Sialic acid metabolism


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Casp9tm1Flv/Casp9tm1Flv
Genetic Background: B6.129S1-Casp9tm1Flv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000042684 Npl / Q9DCJ9 / N-acetylneuraminate lyase / Q9BXD5* / N-acetylneuraminate pyruvate lyase*  / complex






 

1 s.

 
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