ENSG00000135905


Homo sapiens

Features
Gene ID: ENSG00000135905
  
Biological name :DOCK10
  
Synonyms : dedicator of cytokinesis 10 / DOCK10 / Q96BY6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: q36.2
Gene start: 224765090
Gene end: 225042445
  
Corresponding Affymetrix probe sets: 215151_at (Human Genome U133 Plus 2.0 Array)   219279_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000494731
Ensembl peptide - ENSP00000437947
Ensembl peptide - ENSP00000493664
Ensembl peptide - ENSP00000258390
Ensembl peptide - ENSP00000386694
Ensembl peptide - ENSP00000394552
Ensembl peptide - ENSP00000395178
Ensembl peptide - ENSP00000397389
NCBI entrez gene - 55619     See in Manteia.
OMIM - 611518
RefSeq - XM_017004447
RefSeq - XM_006712617
RefSeq - XM_017004441
RefSeq - XM_017004442
RefSeq - XM_017004443
RefSeq - XM_017004444
RefSeq - XM_017004445
RefSeq - XM_017004446
RefSeq - NM_001290263
RefSeq - NM_014689
RefSeq - XM_005246673
RefSeq Peptide - NP_001277192
RefSeq Peptide - NP_055504
swissprot - H7C0I3
swissprot - F8WE73
swissprot - F8WB48
swissprot - Q96BY6
swissprot - H0YFC5
Ensembl - ENSG00000135905
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock10ENSDARG00000075327Danio rerio
 DOCK10ENSGALG00000005030Gallus gallus
 Dock10ENSMUSG00000038608Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOCK9 / Q9BZ29 / dedicator of cytokinesis 9ENSG0000008838751
DOCK11 / Q5JSL3 / dedicator of cytokinesis 11ENSG0000014725149
DOCK7 / Q96N67 / dedicator of cytokinesis 7ENSG0000011664127
DOCK8 / Q8NF50 / dedicator of cytokinesis 8ENSG0000010709927
DOCK6 / Q96HP0 / dedicator of cytokinesis 6ENSG0000013015826


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR016024  Armadillo-type fold
 IPR021816  Dedicator of cytokinesis C/D, N-terminal
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis ISS
 biological_processGO:0002315 marginal zone B cell differentiation ISS
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0030334 regulation of cell migration IDA
 biological_processGO:0043547 positive regulation of GTPase activity ISS
 biological_processGO:0060997 dendritic spine morphogenesis ISS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043197 dendritic spine ISS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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