ENSG00000147251


Homo sapiens

Features
Gene ID: ENSG00000147251
  
Biological name :DOCK11
  
Synonyms : dedicator of cytokinesis 11 / DOCK11 / Q5JSL3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: X
Strand: 1
Band: q24
Gene start: 118495898
Gene end: 118686163
  
Corresponding Affymetrix probe sets: 226875_at (Human Genome U133 Plus 2.0 Array)   238356_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000276202
Ensembl peptide - ENSP00000488503
Ensembl peptide - ENSP00000487829
Ensembl peptide - ENSP00000276204
NCBI entrez gene - 139818     See in Manteia.
OMIM - 300681
RefSeq - XM_005262368
RefSeq - XM_011531278
RefSeq - XM_011531276
RefSeq - NM_144658
RefSeq - XM_005262369
RefSeq Peptide - NP_653259
swissprot - Q5JSL3
swissprot - A6NIW2
swissprot - A0A0J9YW64
swissprot - A0A0J9YXQ7
Ensembl - ENSG00000147251
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 dock11ENSDARG00000062485Danio rerio
 DOCK11ENSGALG00000006017Gallus gallus
 A2AF47ENSMUSG00000031093Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DOCK9 / Q9BZ29 / dedicator of cytokinesis 9ENSG0000008838759
DOCK10 / Q96BY6 / dedicator of cytokinesis 10ENSG0000013590552
DOCK7 / Q96N67 / dedicator of cytokinesis 7ENSG0000011664130
DOCK6 / Q96HP0 / dedicator of cytokinesis 6ENSG0000013015830
DOCK8 / Q8NF50 / dedicator of cytokinesis 8ENSG0000010709930


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR010703  Dedicator of cytokinesis, C-terminal
 IPR011989  Armadillo-like helical
 IPR011993  PH-like domain superfamily
 IPR016024  Armadillo-type fold
 IPR021816  Dedicator of cytokinesis C/D, N-terminal
 IPR026791  Dedicator of cytokinesis
 IPR027007  DHR-1 domain
 IPR027357  DHR-2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001782 B cell homeostasis IEA
 biological_processGO:0002315 marginal zone B cell differentiation IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0007596 blood coagulation TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0051491 positive regulation of filopodium assembly IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0017048 Rho GTPase binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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