ENSG00000136371


Homo sapiens

Features
Gene ID: ENSG00000136371
  
Biological name :MTHFS
  
Synonyms : methenyltetrahydrofolate synthetase / MTHFS / P49914
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: -1
Band: q25.1
Gene start: 79833585
Gene end: 79897379
  
Corresponding Affymetrix probe sets: 203433_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000489076
Ensembl peptide - ENSP00000258874
Ensembl peptide - ENSP00000454318
Ensembl peptide - ENSP00000454626
NCBI entrez gene - 10588     See in Manteia.
OMIM - 604197
RefSeq - NM_001199758
RefSeq - NM_006441
RefSeq Peptide - NP_001186687
RefSeq Peptide - NP_006432
swissprot - P49914
swissprot - A0A0U1RQM3
swissprot - H3BMB9
swissprot - H3BN04
Ensembl - ENSG00000136371
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfsENSDARG00000104487Danio rerio
 MTHFSENSGALG00000006516Gallus gallus
 MthfsENSMUSG00000066442Mus musculus
 MthfslENSMUSG00000079427Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ST20-MTHFS / ST20-MTHFS readthroughENSG0000025933283


Protein motifs (from Interpro)
Interpro ID Name
 IPR002698  5-formyltetrahydrofolate cyclo-ligase
 IPR037171  NagB/RpiA transferase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006536 glutamate metabolic process IMP
 biological_processGO:0009396 folic acid-containing compound biosynthetic process IBA
 biological_processGO:0015942 formate metabolic process NAS
 biological_processGO:0035999 tetrahydrofolate interconversion IMP
 biological_processGO:0046653 tetrahydrofolate metabolic process IDA
 biological_processGO:0046655 folic acid metabolic process TAS
 biological_processGO:0046657 folic acid catabolic process IMP
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005759 mitochondrial matrix IDA
 cellular_componentGO:0005829 cytosol TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0005542 folic acid binding IDA
 molecular_functionGO:0016874 ligase activity IEA
 molecular_functionGO:0030272 5-formyltetrahydrofolate cyclo-ligase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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