Manteia

ENSMUSG00000066442

Mus musculus

Features

Gene ID:	ENSMUSG00000066442

Biological name :	Mthfs

Synonyms :	5-formyltetrahydrofolate cyclo-ligase / Mthfs / Q9D110

Possible biological names infered from orthology :	methenyltetrahydrofolate synthetase / P49914 / ST20-MTHFS / ST20-MTHFS readthrough

Species:	Mus musculus

Chr. number:	9
Strand:	1
Band:	E3.1
Gene start:	89210676
Gene end:	89377713

Corresponding Affymetrix probe sets:	10587695 (MoGene1.0st) 10595630 (MoGene1.0st) 1443021_at (Mouse Genome 430 2.0 Array) 1460257_a_at (Mouse Genome 430 2.0 Array)

Cross references:	Ensembl peptide - ENSMUSP00000082354 Ensembl peptide - ENSMUSP00000139738 Ensembl peptide - ENSMUSP00000112695 NCBI entrez gene - 107885 See in Manteia. MGI - MGI:1340032 RefSeq - NM_026829 RefSeq Peptide - NP_081105 swissprot - B2KF83 swissprot - A0A087WPE2 swissprot - Q9D110 Ensembl - ENSMUSG00000066442

See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed

Ortholog prediction (from Ensembl)

Paralog prediction (from Ensembl)

Paralog name	ID	Similarity(%)
Mthfsl / MTHFS* / P49914* / ST20-MTHFS* / ST20-MTHFS readthrough* / methenyltetrahydrofolate synthetase*	ENSMUSG00000079427	99

Protein motifs (from Interpro)

Interpro ID	Name
IPR002698	5-formyltetrahydrofolate cyclo-ligase
IPR037171	NagB/RpiA transferase-like

Gene Ontology (GO)

Type	GO ID	Term	Ev.Code
biological_process	GO:0009396	folic acid-containing compound biosynthetic process	IBA
biological_process	GO:0035999	tetrahydrofolate interconversion	IBA
biological_process	GO:0046653	tetrahydrofolate metabolic process	ISS
cellular_component	GO:0005737	cytoplasm	IEA
cellular_component	GO:0005739	mitochondrion	IDA
cellular_component	GO:0005759	mitochondrial matrix	ISO
cellular_component	GO:0005829	cytosol	ISO
cellular_component	GO:0016020	membrane	IEA
cellular_component	GO:0016021	integral component of membrane	IEA
molecular_function	GO:0000166	nucleotide binding	IEA
molecular_function	GO:0005524	ATP binding	ISO
molecular_function	GO:0005542	folic acid binding	IEA
molecular_function	GO:0016874	ligase activity	IEA
molecular_function	GO:0030272	5-formyltetrahydrofolate cyclo-ligase activity	ISO
molecular_function	GO:0046872	metal ion binding	IEA

Pathways (from Reactome)

Pathway description

Metabolism of folate and pterines

Phenotype (from MGI, Zfin or HPO)

ID	Phenotype	Definition	Genetic BG
MP:0005584	abnormal enzyme/coenzyme activity	"altered ability of any of these proteins, or their cofactors, to act as catalysts to induce chemical changes in other substances" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]	Show Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011092	complete embryonic lethality	"death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]	Show Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
MP:0011230	abnormal folic acid level	"any anomaly in the concentration of the vitamin B family member that stimulates the hematopoietic system, is present in the liver and kidney and is found in mushrooms, spinach, yeast, green leaves, and grasses, and is used in the treatment and prevention of folate deficiencies and megaloblastic anemia" [MESH:D03.438.733.631.400]	Show Allelic Composition: Ace^tm9Keb/Ace^tm9Keb Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Interacting proteins (from Reactome)

Interactor ID

Name

Interaction type

No match

0 s.

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		© Olivier Tassy / Olivier Pourquie 2007-2024 contact: otassy@igbmc.fr