ENSMUSG00000079427


Mus musculus

Features
Gene ID: ENSMUSG00000079427
  
Biological name :Mthfsl
  
Synonyms : Mthfsl
  
Possible biological names infered from orthology : methenyltetrahydrofolate synthetase / MTHFS / P49914 / ST20-MTHFS / ST20-MTHFS readthrough
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: E3.1
Gene start: 88688602
Gene end: 88720296
  
Corresponding Affymetrix probe sets: 10587695 (MoGene1.0st)   10595630 (MoGene1.0st)   1443021_at (Mouse Genome 430 2.0 Array)   1460257_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000108734
Ensembl peptide - ENSMUSP00000150907
NCBI entrez gene - 100039707     See in Manteia.
MGI - MGI:3780550
RefSeq - XM_006510730
RefSeq - NM_001128601
RefSeq - XM_006510729
RefSeq Peptide - NP_001122073
swissprot - Q8R1G5
swissprot - L7N466
Ensembl - ENSMUSG00000079427
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mthfsENSDARG00000104487Danio rerio
 MTHFSENSGALG00000006516Gallus gallus
 MTHFSENSG00000136371Homo sapiens
 ST20-MTHFSENSG00000259332Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Mthfs / Q9D110 / 5-formyltetrahydrofolate cyclo-ligase / P49914* / ST20-MTHFS* / ST20-MTHFS readthrough* / methenyltetrahydrofolate synthetase*ENSMUSG0000006644299


Protein motifs (from Interpro)
Interpro ID Name
 IPR002698  5-formyltetrahydrofolate cyclo-ligase
 IPR037171  NagB/RpiA transferase-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0009396 folic acid-containing compound biosynthetic process IBA
 biological_processGO:0035999 tetrahydrofolate interconversion IBA
 cellular_componentGO:0005737 cytoplasm ISO
 cellular_componentGO:0005739 mitochondrion IBA
 cellular_componentGO:0005759 mitochondrial matrix ISO
 cellular_componentGO:0005829 cytosol ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0005542 folic acid binding ISO
 molecular_functionGO:0030272 5-formyltetrahydrofolate cyclo-ligase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Metabolism of folate and pterines


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0010052 increased grip strength "greater ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
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Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Mmp9tm1b(EUCOMM)Wtsi/Mmp9tm1b(EUCOMM)Wtsi
Genetic Background: C57BL/6N-Mmp9tm1b(EUCOMM)Wtsi/Ics

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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