ENSG00000136754


Homo sapiens

Features
Gene ID: ENSG00000136754
  
Biological name :ABI1
  
Synonyms : ABI1 / abl interactor 1 / Q8IZP0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: p12.1
Gene start: 26746593
Gene end: 26861087
  
Corresponding Affymetrix probe sets: 1559890_a_at (Human Genome U133 Plus 2.0 Array)   209027_s_at (Human Genome U133 Plus 2.0 Array)   209028_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365336
Ensembl peptide - ENSP00000365330
Ensembl peptide - ENSP00000365340
Ensembl peptide - ENSP00000440101
Ensembl peptide - ENSP00000439646
Ensembl peptide - ENSP00000279599
Ensembl peptide - ENSP00000352114
Ensembl peptide - ENSP00000365307
Ensembl peptide - ENSP00000365308
Ensembl peptide - ENSP00000365309
Ensembl peptide - ENSP00000365310
Ensembl peptide - ENSP00000365312
NCBI entrez gene - 10006     See in Manteia.
OMIM - 603050
RefSeq - XM_017015459
RefSeq - NM_001178116
RefSeq - NM_001178119
RefSeq - NM_001178120
RefSeq - NM_001178121
RefSeq - NM_001178122
RefSeq - NM_001178123
RefSeq - NM_001178124
RefSeq - NM_001178125
RefSeq - NM_001348029
RefSeq - NM_001348030
RefSeq - NM_005470
RefSeq - XM_005252332
RefSeq - XM_005252333
RefSeq - XM_006717359
RefSeq - XM_006717360
RefSeq - XM_006717361
RefSeq - XM_011519289
RefSeq - XM_017015458
RefSeq - NM_001012750
RefSeq - NM_001012751
RefSeq - NM_001012752
RefSeq Peptide - NP_001012769
RefSeq Peptide - NP_001334958
RefSeq Peptide - NP_001334959
RefSeq Peptide - NP_005461
RefSeq Peptide - NP_001012768
RefSeq Peptide - NP_001012770
RefSeq Peptide - NP_001171587
RefSeq Peptide - NP_001171590
RefSeq Peptide - NP_001171591
RefSeq Peptide - NP_001171592
RefSeq Peptide - NP_001171593
RefSeq Peptide - NP_001171594
RefSeq Peptide - NP_001171595
RefSeq Peptide - NP_001171596
swissprot - B6VEX3
swissprot - Q8IZP0
swissprot - A0A0A0MRT6
swissprot - B6VEX4
Ensembl - ENSG00000136754
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abi1aENSDARG00000010155Danio rerio
 abi1bENSDARG00000062991Danio rerio
 ABI1ENSGALG00000007547Gallus gallus
 Abi1ENSMUSG00000058835Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABI2 / Q9NYB9 / abl interactor 2ENSG0000013844367
ABI3 / Q9P2A4 / ABI family member 3ENSG0000010879832


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR001452  SH3 domain
 IPR012849  Abl-interactor, homeo-domain homologous domain
 IPR028456  Abl interactor 1
 IPR028457  ABI family
 IPR035725  Abl Interactor 1, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IEA
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway TAS
 biological_processGO:0008154 actin polymerization or depolymerization NAS
 biological_processGO:0008285 negative regulation of cell proliferation TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:0035855 megakaryocyte development IEA
 biological_processGO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis TAS
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway TAS
 biological_processGO:0048813 dendrite morphogenesis IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0072673 lamellipodium morphogenesis IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum TAS
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031209 SCAR complex IDA
 cellular_componentGO:0031252 cell leading edge IEA
 cellular_componentGO:0032433 filopodium tip IDA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding TAS
 molecular_functionGO:0017124 SH3 domain binding IPI
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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