ENSMUSG00000058835


Mus musculus

Features
Gene ID: ENSMUSG00000058835
  
Biological name :Abi1
  
Synonyms : Abi1 / abl-interactor 1 / Q8CBW3
  
Possible biological names infered from orthology : Q8IZP0
  
Species: Mus musculus
  
Chr. number: 2
Strand: -1
Band: A3
Gene start: 22940073
Gene end: 23040241
  
Corresponding Affymetrix probe sets: 10480423 (MoGene1.0st)   1423177_a_at (Mouse Genome 430 2.0 Array)   1423178_at (Mouse Genome 430 2.0 Array)   1438506_s_at (Mouse Genome 430 2.0 Array)   1450890_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000118491
Ensembl peptide - ENSMUSP00000117335
Ensembl peptide - ENSMUSP00000120462
Ensembl peptide - ENSMUSP00000136846
Ensembl peptide - ENSMUSP00000120769
Ensembl peptide - ENSMUSP00000120621
Ensembl peptide - ENSMUSP00000077997
Ensembl peptide - ENSMUSP00000088957
Ensembl peptide - ENSMUSP00000090860
Ensembl peptide - ENSMUSP00000110191
Ensembl peptide - ENSMUSP00000116093
NCBI entrez gene - 11308     See in Manteia.
MGI - MGI:104913
RefSeq - NM_145994
RefSeq - NM_001077190
RefSeq - NM_001077192
RefSeq - NM_001077193
RefSeq - NM_001331043
RefSeq - NM_001331044
RefSeq - NM_001331045
RefSeq - NM_007380
RefSeq - XM_006497617
RefSeq - XM_006497618
RefSeq - XM_006497619
RefSeq - XM_006497620
RefSeq Peptide - NP_001317972
RefSeq Peptide - NP_001317973
RefSeq Peptide - NP_001317974
RefSeq Peptide - NP_031406
RefSeq Peptide - NP_666106
RefSeq Peptide - NP_001070658
RefSeq Peptide - NP_001070660
RefSeq Peptide - NP_001070661
swissprot - Q3TJR5
swissprot - Q8CBW3
swissprot - Q3TPY5
swissprot - B7ZCU0
swissprot - B7ZCU5
swissprot - B7ZCU4
swissprot - B7ZCU3
swissprot - J3QNK8
swissprot - B7ZCU2
swissprot - Q3TJ64
Ensembl - ENSMUSG00000058835
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abi1aENSDARG00000010155Danio rerio
 abi1bENSDARG00000062991Danio rerio
 ABI1ENSGALG00000007547Gallus gallus
 ABI1ENSG00000136754Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abi2 / P62484 / abl-interactor 2 / Q9NYB9*ENSMUSG0000002678264
Abi3 / Q8BYZ1 / ABI gene family, member 3 / Q9P2A4* / ABI family member 3*ENSMUSG0000001838132


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR001452  SH3 domain
 IPR012849  Abl-interactor, homeo-domain homologous domain
 IPR028456  Abl interactor 1
 IPR028457  ABI family
 IPR035725  Abl Interactor 1, SH3 domain
 IPR036028  SH3-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001756 somitogenesis IMP
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0035855 megakaryocyte development IMP
 biological_processGO:0048813 dendrite morphogenesis IDA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0072673 lamellipodium morphogenesis IMP
 cellular_componentGO:0005622 intracellular ISO
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0014069 postsynaptic density IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030426 growth cone IEA
 cellular_componentGO:0031209 SCAR complex ISO
 cellular_componentGO:0031252 cell leading edge IDA
 cellular_componentGO:0032433 filopodium tip IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043005 neuron projection IDA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0045211 postsynaptic membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0044877 protein-containing complex binding IEA
 molecular_functionGO:0045296 cadherin binding ISO


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000914 exencephaly "neurocranial defects resulting in exposure or extrusion of the brain" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
Show

Allelic Composition: Xisttm5.1Nbd/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0000929 open neural tube "incomplete invagination and fusion of the neuroepithelial layer in early development" [MGI:CLS, J:53370, J:62571]
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Allelic Composition: Xisttm5.1Nbd/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0000930 wavy neural tube "undulations in the embryonic neural tube" [J:37888]
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Allelic Composition: Xisttm5.1Nbd/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001634 internal hemorrhage "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170]
Show

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0001787 pericardial edema "accumulation of watery fluid in the pericardial sac of the heart" [J:52597]
Show

Allelic Composition: Xisttm5.1Nbd/Y
Genetic Background: involves: 129P2/OlaHsd

 MP:0002190 disorganized myocardium "malformed or poorly developed cardiac muscle layers" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67044]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0002836 abnormal chorion "malformations of the outermost extraembryonic membrane" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0003057 abnormal epicardium morphology "anomalous structure of the visceral layer of the pericardium that surrounds and attaches to all the surfaces of the heart" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8, ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003229 abnormal vitelline vasculature "malformation in the vessels of the yolk sac" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93257]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003974 abnormal endocardium morphology "malformation of the thin serous membrane, primarily composed of endothelial tissue, that lines the interior of the heart" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

Allelic Composition: Abi1tm1.2Lko/Abi1tm1.2Lko
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0004937 dilated heart "stretched or widened aperture of the luminal spaces of the heart, usually with an increase in contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abi1tm1.2Lko/Abi1tm1.2Lko
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0010395 abnormal branchial arch development "abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abi1tm1.2Lko/Abi1tm1.2Lko
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0010545 abnormal heart layer morphology "any structural anomaly of the laminar structure of the heart" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Abi1tm1Pen/Abi1tm1Pen
Genetic Background: involves: C57BL/6

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

Allelic Composition: Abi1tm1.2Lko/Abi1tm1.2Lko
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

 MP:0012095 increased Reichert s membrane thickness "increased width of the extraembryonic basement membrane that forms on the inner surface of the trophectoderm during placenta morphogenesis and is secreted by the distal parietal endoderm" [MGI:anna]
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Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0012270 cardiac edema "abnormal accumulation of fluid in the interstitial tissues and cavities of the body due to impaired cardiac function or congestive heart failure; usually characterized by increased venous and capillary pressures and often associated with renal sodium retention" [MGI:anna]
Show

Allelic Composition: Abi1tm1.2Lko/Abi1tm1.2Lko
Genetic Background: involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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