ENSMUSG00000026782


Mus musculus

Features
Gene ID: ENSMUSG00000026782
  
Biological name :Abi2
  
Synonyms : Abi2 / abl-interactor 2 / P62484
  
Possible biological names infered from orthology : Q9NYB9
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: C2
Gene start: 60409619
Gene end: 60481158
  
Corresponding Affymetrix probe sets: 10346764 (MoGene1.0st)   1433985_at (Mouse Genome 430 2.0 Array)   1436984_at (Mouse Genome 430 2.0 Array)   1458053_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000139646
Ensembl peptide - ENSMUSP00000139501
Ensembl peptide - ENSMUSP00000139743
Ensembl peptide - ENSMUSP00000141068
Ensembl peptide - ENSMUSP00000140750
Ensembl peptide - ENSMUSP00000140522
Ensembl peptide - ENSMUSP00000140274
Ensembl peptide - ENSMUSP00000139867
Ensembl peptide - ENSMUSP00000058754
Ensembl peptide - ENSMUSP00000139483
NCBI entrez gene - 329165     See in Manteia.
MGI - MGI:106913
RefSeq - XM_017321250
RefSeq - XM_006496078
RefSeq - XM_006496079
RefSeq - XM_006496080
RefSeq - XM_006496081
RefSeq - XM_006496084
RefSeq - XM_006496085
RefSeq - XM_011238539
RefSeq - XM_017321240
RefSeq - XM_017321244
RefSeq - XM_017321245
RefSeq - XM_017321246
RefSeq - XM_017321247
RefSeq - XM_017321249
RefSeq - NM_001198570
RefSeq - NM_001198571
RefSeq - NM_198127
RefSeq - XM_006496075
RefSeq - XM_006496076
RefSeq - XM_006496077
RefSeq Peptide - NP_001185500
RefSeq Peptide - NP_937760
RefSeq Peptide - NP_001185499
swissprot - A0A087WPE6
swissprot - A0A087WP64
swissprot - A0A087WNU9
swissprot - Q6AXD2
swissprot - Q6AXH6
swissprot - A0A087WNT3
swissprot - A0A087WRS3
swissprot - P62484
swissprot - A0A087WR90
swissprot - A0A087WPP8
Ensembl - ENSMUSG00000026782
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abi2aENSDARG00000058207Danio rerio
 abi2bENSDARG00000014875Danio rerio
 ABI2ENSGALG00000008714Gallus gallus
 ABI2ENSG00000138443Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Abi1 / Q8CBW3 / abl-interactor 1 / Q8IZP0*ENSMUSG0000005883563
Abi3 / Q8BYZ1 / ABI gene family, member 3 / Q9P2A4* / ABI family member 3*ENSMUSG0000001838128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR001452  SH3 domain
 IPR012849  Abl-interactor, homeo-domain homologous domain
 IPR028456  Abl interactor 1
 IPR028457  ABI family
 IPR035726  Abl interactor 2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036993  ABL interactor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007611 learning or memory IMP
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0016358 dendrite development IMP
 biological_processGO:0016477 cell migration IMP
 biological_processGO:0016601 Rac protein signal transduction ISO
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation ISO
 biological_processGO:0043010 camera-type eye development IMP
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031209 SCAR complex ISO
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0017124 SH3 domain binding ISO
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding ISO
 molecular_functionGO:0048365 Rac GTPase binding ISO
 molecular_functionGO:0070064 proline-rich region binding ISO


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000780 abnormal corpus callosum morphology "malformation or absence of a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres; it consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0000788 abnormal cerebral cortex morphology "malformed gray cellular mantle covering the surface of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:38857]
Show

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0000807 abnormal hippocampus morphology "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857]
Show

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0000812 abnormal dentate gyrus morphology "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857]
Show

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0001297 microphthalmia "reduced average size of the eyes" [J:18048]
Show

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0001469 abnormal contextual conditioning "defect in the ability of an animal to learn and remember an association between an an aversive experience (the unconditioned stimulus (US), ususally a shock) and a neutral stimulus (the conditioned stimulus (CS), or the environmental context in this case)" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

Allelic Composition: Abi2tm1Pen/Abi2+
Genetic Background: B6.Cg-Abi2tm1Pen

 MP:0002579 disorganized secondary lens fibers "deformation or misalignment of the elongated cells that form the crystalline lens" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator, J:70385]
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Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0003236 abnormal lens capsule morphology "malformation in the elastic, clear, membrane-like structure, that is outer most layer of the lens" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:93301]
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Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0005545 abnormal lens development "aberrant formation of the transparent structure of the eye responsible for focusing light rays" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0005621 abnormal cell physiology "aberration in the vital processes of the cell " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Bmp4tm1Jfm/Bmp4tm1Jfm,Tg(Mef2c-cre)2Blk/0
Genetic Background: involves: 129S4/SvJaeSor

 MP:0008263 abnormal hippocampus CA1 region morphology 
Show

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

Allelic Composition: Abi2tm1Pen/Abi2+
Genetic Background: B6.Cg-Abi2tm1Pen

 MP:0008284 abnormal hippocampus pyramidal cell layer 
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Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Clockm1Jt/Clockm1Jt
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0009940 abnormal hippocampus pyramidal cell morphology "any structural anomaly of the projection neuron in the pyramidal layer of the hippocampus" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Abi2tm1Pen/Abi2+
Genetic Background: B6.Cg-Abi2tm1Pen

 MP:0009969 abnormal cerebral cortex pyramidal cell morphology "any structural anomaly of the projection neurons in the pyramidal cell layer of the cerebral cortex" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Grhl3ct-2J/Grhl3ct-2J
Genetic Background: C57BL/6J-ct2J/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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