ENSG00000138443


Homo sapiens

Features
Gene ID: ENSG00000138443
  
Biological name :ABI2
  
Synonyms : ABI2 / abl interactor 2 / Q9NYB9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q33.2
Gene start: 203328219
Gene end: 203447723
  
Corresponding Affymetrix probe sets: 207268_x_at (Human Genome U133 Plus 2.0 Array)   209856_x_at (Human Genome U133 Plus 2.0 Array)   211793_s_at (Human Genome U133 Plus 2.0 Array)   216113_at (Human Genome U133 Plus 2.0 Array)   225098_at (Human Genome U133 Plus 2.0 Array)   225112_at (Human Genome U133 Plus 2.0 Array)   231075_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000405255
Ensembl peptide - ENSP00000404352
Ensembl peptide - ENSP00000405801
Ensembl peptide - ENSP00000414703
Ensembl peptide - ENSP00000413375
Ensembl peptide - ENSP00000410509
Ensembl peptide - ENSP00000408898
Ensembl peptide - ENSP00000408334
Ensembl peptide - ENSP00000261016
Ensembl peptide - ENSP00000261017
Ensembl peptide - ENSP00000261018
Ensembl peptide - ENSP00000295851
Ensembl peptide - ENSP00000391433
Ensembl peptide - ENSP00000396249
Ensembl peptide - ENSP00000397850
Ensembl peptide - ENSP00000398487
Ensembl peptide - ENSP00000399040
NCBI entrez gene - 10152     See in Manteia.
OMIM - 606442
RefSeq - XM_017003146
RefSeq - XM_017003125
RefSeq - XM_017003126
RefSeq - XM_017003127
RefSeq - XM_017003128
RefSeq - XM_017003129
RefSeq - XM_017003130
RefSeq - XM_017003131
RefSeq - XM_017003132
RefSeq - XM_017003133
RefSeq - XM_017003134
RefSeq - XM_017003135
RefSeq - XM_017003136
RefSeq - XM_017003137
RefSeq - XM_017003138
RefSeq - XM_017003139
RefSeq - XM_017003140
RefSeq - XM_017003141
RefSeq - XM_017003142
RefSeq - XM_017003143
RefSeq - XM_017003144
RefSeq - XM_017003145
RefSeq - NM_001282925
RefSeq - NM_001282926
RefSeq - NM_001282927
RefSeq - NM_001282932
RefSeq - NM_005759
RefSeq - XM_005246217
RefSeq - XM_005246218
RefSeq - XM_005246221
RefSeq - XM_005246225
RefSeq - XM_005246226
RefSeq - XM_006712174
RefSeq - XM_006712177
RefSeq - XM_006712179
RefSeq - XM_006712180
RefSeq - XM_006712181
RefSeq - XM_006712182
RefSeq - XM_006712185
RefSeq - XM_006712186
RefSeq - XM_011510472
RefSeq - XM_011510473
RefSeq - XM_017003118
RefSeq - XM_017003119
RefSeq - XM_017003120
RefSeq - XM_017003121
RefSeq - XM_017003122
RefSeq - XM_017003123
RefSeq - XM_017003124
RefSeq Peptide - NP_005750
RefSeq Peptide - NP_001269856
RefSeq Peptide - NP_001269861
RefSeq Peptide - NP_001269854
RefSeq Peptide - NP_001269855
swissprot - F8WAL6
swissprot - F8WAQ3
swissprot - F8WAU3
swissprot - F8WAZ8
swissprot - F8WBL5
swissprot - E9PEZ7
swissprot - F8WEB9
swissprot - H0Y6B5
swissprot - H7C3Q7
swissprot - Q9NYB9
swissprot - A0A0C4DG21
swissprot - F8WCD7
swissprot - E7EW77
swissprot - E7EUA1
swissprot - E7EP65
swissprot - B7Z836
Ensembl - ENSG00000138443
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 abi2aENSDARG00000058207Danio rerio
 abi2bENSDARG00000014875Danio rerio
 ABI2ENSGALG00000008714Gallus gallus
 Abi2ENSMUSG00000026782Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ABI1 / Q8IZP0 / abl interactor 1ENSG0000013675466
ABI3 / Q9P2A4 / ABI family member 3ENSG0000010879830


Protein motifs (from Interpro)
Interpro ID Name
 IPR000727  Target SNARE coiled-coil homology domain
 IPR001452  SH3 domain
 IPR012849  Abl-interactor, homeo-domain homologous domain
 IPR028456  Abl interactor 1
 IPR028457  ABI family
 IPR035726  Abl interactor 2, SH3 domain
 IPR036028  SH3-like domain superfamily
 IPR036993  ABL interactor 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007010 cytoskeleton organization TAS
 biological_processGO:0008154 actin polymerization or depolymerization IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016477 cell migration TAS
 biological_processGO:0016601 Rac protein signal transduction IDA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IDA
 biological_processGO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation IDA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005829 cytosol IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030175 filopodium IEA
 cellular_componentGO:0031209 SCAR complex IDA
 cellular_componentGO:0032433 filopodium tip IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0008093 cytoskeletal adaptor activity TAS
 molecular_functionGO:0017124 SH3 domain binding TAS
 molecular_functionGO:0019900 kinase binding NAS
 molecular_functionGO:0030296 protein tyrosine kinase activator activity IEA
 molecular_functionGO:0031625 ubiquitin protein ligase binding IPI
 molecular_functionGO:0044877 protein-containing complex binding IDA
 molecular_functionGO:0048365 Rac GTPase binding IDA
 molecular_functionGO:0070064 proline-rich region binding IPI


Pathways (from Reactome)
Pathway description
Regulation of actin dynamics for phagocytic cup formation
VEGFA-VEGFR2 Pathway
RHO GTPases Activate WASPs and WAVEs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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