ENSG00000136999


Homo sapiens

Features
Gene ID: ENSG00000136999
  
Biological name :NOV
  
Synonyms : nephroblastoma overexpressed / NOV / P48745
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: 1
Band: q24.12
Gene start: 119416306
Gene end: 119424353
  
Corresponding Affymetrix probe sets: 204501_at (Human Genome U133 Plus 2.0 Array)   214321_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000259526
NCBI entrez gene - 4856     See in Manteia.
OMIM - 164958
RefSeq - NM_002514
RefSeq Peptide - NP_002505
swissprot - A0A024R9J4
swissprot - P48745
Ensembl - ENSG00000136999
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOVENSGALG00000038364Gallus gallus
 NovENSMUSG00000037362Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTGF / P29279 / connective tissue growth factorENSG0000011852349
CYR61 / O00622 / cysteine rich angiogenic inducer 61ENSG0000014287142
WISP1 / O95388 / WNT1 inducible signaling pathway protein 1ENSG0000010441536
WISP3 / O95389 / WNT1 inducible signaling pathway protein 3ENSG0000011276134
WISP2 / O76076 / WNT1 inducible signaling pathway protein 2ENSG0000006420530


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR006207  Cystine knot, C-terminal
 IPR006208  Glycoprotein hormone subunit beta
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR012395  IGFBP-related, CNN
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IDA
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0002062 chondrocyte differentiation IMP
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010761 fibroblast migration IDA
 biological_processGO:0010832 negative regulation of myotube differentiation IDA
 biological_processGO:0014909 smooth muscle cell migration IDA
 biological_processGO:0030308 negative regulation of cell growth IMP
 biological_processGO:0033627 cell adhesion mediated by integrin IDA
 biological_processGO:0035767 endothelial cell chemotaxis IDA
 biological_processGO:0044342 type B pancreatic cell proliferation ISS
 biological_processGO:0045747 positive regulation of Notch signaling pathway IDA
 biological_processGO:0046676 negative regulation of insulin secretion ISS
 biological_processGO:0048659 smooth muscle cell proliferation IDA
 biological_processGO:0050728 negative regulation of inflammatory response ISS
 biological_processGO:0060326 cell chemotaxis IDA
 biological_processGO:0060392 negative regulation of SMAD protein signal transduction ISS
 biological_processGO:0060548 negative regulation of cell death IBA
 biological_processGO:0061484 hematopoietic stem cell homeostasis IMP
 biological_processGO:0071603 endothelial cell-cell adhesion IDA
 biological_processGO:0090027 negative regulation of monocyte chemotaxis IMP
 biological_processGO:1902731 negative regulation of chondrocyte proliferation IMP
 biological_processGO:1904057 negative regulation of sensory perception of pain ISS
 biological_processGO:1990523 bone regeneration ISS
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005921 gap junction ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0005112 Notch binding IPI
 molecular_functionGO:0005178 integrin binding IPI
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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