ENSMUSG00000037362


Mus musculus

Features
Gene ID: ENSMUSG00000037362
  
Biological name :Nov
  
Synonyms : nephroblastoma overexpressed / Nov / Q64299
  
Possible biological names infered from orthology : P48745
  
Species: Mus musculus
  
Chr. number: 15
Strand: 1
Band: D1
Gene start: 54745702
Gene end: 54754039
  
Corresponding Affymetrix probe sets: 10424119 (MoGene1.0st)   1426851_a_at (Mouse Genome 430 2.0 Array)   1426852_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000054389
NCBI entrez gene - 18133     See in Manteia.
MGI - MGI:109185
RefSeq - NM_010930
RefSeq Peptide - NP_035060
swissprot - Q64299
Ensembl - ENSMUSG00000037362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOVENSGALG00000038364Gallus gallus
 NOVENSG00000136999Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctgf / P29268 / Connective tissue growth factor / P29279*ENSMUSG0000001999748
Cyr61 / P18406 / Protein CYR61 / O00622* / cysteine rich angiogenic inducer 61*ENSMUSG0000002819544
Wisp1 / O54775 / WNT1 inducible signaling pathway protein 1 / O95388*ENSMUSG0000000512437
Wisp3 / D3Z5L9 / WNT1 inducible signaling pathway protein 3 / O95389*ENSMUSG0000006207432
Wisp2 / WNT1 inducible signaling pathway protein 2 / O76076*ENSMUSG0000002765628


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR006207  Cystine knot, C-terminal
 IPR006208  Glycoprotein hormone subunit beta
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR012395  IGFBP-related, CNN
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0002062 chondrocyte differentiation IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010761 fibroblast migration IEA
 biological_processGO:0010832 negative regulation of myotube differentiation IEA
 biological_processGO:0014909 smooth muscle cell migration IEA
 biological_processGO:0030308 negative regulation of cell growth IEA
 biological_processGO:0033627 cell adhesion mediated by integrin IEA
 biological_processGO:0035767 endothelial cell chemotaxis IEA
 biological_processGO:0044342 type B pancreatic cell proliferation IDA
 biological_processGO:0045747 positive regulation of Notch signaling pathway IEA
 biological_processGO:0046676 negative regulation of insulin secretion IDA
 biological_processGO:0048659 smooth muscle cell proliferation IEA
 biological_processGO:0050728 negative regulation of inflammatory response IMP
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0060392 negative regulation of SMAD protein signal transduction IMP
 biological_processGO:0060548 negative regulation of cell death IBA
 biological_processGO:0061484 hematopoietic stem cell homeostasis IEA
 biological_processGO:0071603 endothelial cell-cell adhesion IEA
 biological_processGO:0090027 negative regulation of monocyte chemotaxis IEA
 biological_processGO:1902731 negative regulation of chondrocyte proliferation IEA
 biological_processGO:1904057 negative regulation of sensory perception of pain IEA
 biological_processGO:1990523 bone regeneration IMP
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005921 gap junction ISS
 cellular_componentGO:0030054 cell junction IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0031012 extracellular matrix IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 molecular_functionGO:0005112 Notch binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0000166 abnormal chondrocyte morphology "anomalous structure, organization, or differentiation of nondividing cartilage cells" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0000439 enlarged skull 
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0000532 kidney vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the organ of secretion" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, tc:Teresa Chu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0000554 abnormal carpal bone morphology "malformation of the nine nodular bones of the joint between the forelimb bones and the front paws consisting of the scapholunar, triangular, greater multiangular, lesser multiangular, capitate, hamate, centrale and the sesamoids" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Anatomy of the Rat:Greene, EC, Hafner Publishing Co, 1935]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0001268 barrel chest "distended circumference of the thoracic and abdominal areas" [J:55583]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0001506 limp posture "lack of rigidity of the carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:60159]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0001533 abnormal skeleton physiology "anomalous function of the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002269 muscular atrophy "a wasting of muscle tissue resulting in a derangement of the muscle fibers; occurs with age, immobilization, weightlessness, malnutrition or denervation" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0002759 abnormal caudal vertebrae morphology "malformed bony segments of the tail, usually 27-30 present" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:82849]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0002837 dystrophic cardiac calcinosis "a condition characterized by the localized deposition of calcium salts in the heart; often occuring in association with inflammation or atherosclerotic lesions and other pathological states" [J:76777, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0002952 ventricular cardiomyopathy "diseases of the ventricles of the heart " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0003385 abnormal body wall "malformation in the external portion of an animal body comprised of ectoderm and mesoderm layers that encloses the body cavity " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0003795 abnormal bone structure 
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0003808 enlarged endocardial cushions "larger than normal mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal" [mac:Megan A. Cassell, Mouse Genome Informatics Curator]
Show

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0004148 increased cortical bone thickness "thicker than normal superficial layer of compact bone" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Novtm1.1Ecan/Novtm1.1Ecan
Genetic Background: B6.Cg-Novtm1.1Ecan

 MP:0004348 long femur "increased length of the long bone of the thigh" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Novtm1.1Ecan/Novtm1.1Ecan
Genetic Background: B6.Cg-Novtm1.1Ecan

 MP:0004695 increased length of long bones "greater end-to-end length of the several elongated bones of the extremities" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Npm1tm1Gsva/Npm1tm1Gsva,Dppa3tm1(cre)Peli/Dppa3+
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd

 MP:0005006 abnormal osteoblast function "anomalous function of this bone-forming cell, which normally forms an osseous matrix in which it becomes enclosed as an osteocyte " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Hdac1tm1.1Pmt/Hdac1tm1.1Pmt,Hdac2tm1.1Pmt/Hdac2tm1.1Pmt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0005353 abnormal patella morphology "anomalous structure of the large sesamoid bone that covers the anterior surface of the knee" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:47316]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0005508 abnormal skeleton morphology "malformation of the bony framework of the body in vertebrates" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Novtm1.1Ecan/Novtm1.1Ecan
Genetic Background: B6.Cg-Novtm1.1Ecan

 MP:0005595 abnormal vascular smooth muscle physiology "anomalous function of the nonstriated, involuntary muscle tissue of the blood vessels" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Npm1tm1Gsva/Npm1tm1Gsva,Dppa3tm1(cre)Peli/Dppa3+
Genetic Background: involves: 129S5/SvEvBrd * 129S7/SvEvBrd

 MP:0006137 venoocclusion "blockage of blood flow through one or more veins" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0008069 abnormal joint mobility "anomaly in the ability to move joints in a full range of motion and with ease" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

Allelic Composition: Novtm1.1Ecan/Novtm1.1Ecan
Genetic Background: B6.Cg-Novtm1.1Ecan

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Novtm1.1Ecan/Novtm1.1Ecan
Genetic Background: B6.Cg-Novtm1.1Ecan

 MP:0008770 decreased survivor rate "a smaller percentage of organisms than expected survive to adulthood and have a lifespan similar to controls" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0008919 fused tarsal bones "anomaly of the eight bones of the instep of the paw/foot resulting in some or all the bones being joined together" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0010019 liver vascular congestion "obstruction of the normal flux of blood within the blood vessel network of the liver" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

 MP:0010869 decreased bone trabecula number "decreased number of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Novtm1.1Ecan/Novtm1.1Ecan
Genetic Background: B6.Cg-Novtm1.1Ecan

 MP:0010876 decreased bone volume "reduced amount of space occupied by bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Novtm1.1Ecan/Novtm1.1Ecan
Genetic Background: B6.Cg-Novtm1.1Ecan

 MP:0011102 partial embryonic lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
Show

Allelic Composition: Rab27aash/Rab27aash
Genetic Background: C3H/HeSn-Rab27aash/JRos

Allelic Composition: Novtm1Cabo/Novtm1Cabo
Genetic Background: involves: 129S/SvEv

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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