ENSMUSG00000028195


Mus musculus

Features
Gene ID: ENSMUSG00000028195
  
Biological name :Cyr61
  
Synonyms : Cyr61 / P18406 / Protein CYR61
  
Possible biological names infered from orthology : cysteine rich angiogenic inducer 61 / O00622
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: H2
Gene start: 145646976
Gene end: 145649981
  
Corresponding Affymetrix probe sets: 10502655 (MoGene1.0st)   1416039_x_at (Mouse Genome 430 2.0 Array)   1438133_a_at (Mouse Genome 430 2.0 Array)   1442340_x_at (Mouse Genome 430 2.0 Array)   1457823_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029846
NCBI entrez gene - 16007     See in Manteia.
MGI - MGI:88613
RefSeq - NM_010516
RefSeq Peptide - NP_034646
swissprot - P18406
swissprot - Q3TX21
Ensembl - ENSMUSG00000028195
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyr61ENSDARG00000023062Danio rerio
 CYR61ENSGALG00000008661Gallus gallus
 CYR61ENSG00000142871Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ctgf / P29268 / Connective tissue growth factor / P29279*ENSMUSG0000001999744
Nov / Q64299 / nephroblastoma overexpressed / P48745*ENSMUSG0000003736241
Wisp1 / O54775 / WNT1 inducible signaling pathway protein 1 / O95388*ENSMUSG0000000512436
Wisp3 / D3Z5L9 / WNT1 inducible signaling pathway protein 3 / O95389*ENSMUSG0000006207431
Wisp2 / WNT1 inducible signaling pathway protein 2 / O76076*ENSMUSG0000002765625


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR006207  Cystine knot, C-terminal
 IPR006208  Glycoprotein hormone subunit beta
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR012395  IGFBP-related, CNN
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001649 osteoblast differentiation IGI
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002041 intussusceptive angiogenesis IMP
 biological_processGO:0003181 atrioventricular valve morphogenesis IMP
 biological_processGO:0003278 apoptotic process involved in heart morphogenesis IMP
 biological_processGO:0003281 ventricular septum development IMP
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007155 cell adhesion IDA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0010518 positive regulation of phospholipase activity IDA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IDA
 biological_processGO:0030198 extracellular matrix organization IDA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IEA
 biological_processGO:0033690 positive regulation of osteoblast proliferation IEA
 biological_processGO:0043065 positive regulation of apoptotic process IGI
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IGI
 biological_processGO:0044319 wound healing, spreading of cells IEA
 biological_processGO:0045597 positive regulation of cell differentiation IDA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IEA
 biological_processGO:0045860 positive regulation of protein kinase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0060413 atrial septum morphogenesis IMP
 biological_processGO:0060591 chondroblast differentiation IDA
 biological_processGO:0060710 chorio-allantoic fusion IMP
 biological_processGO:0060716 labyrinthine layer blood vessel development IMP
 biological_processGO:0061036 positive regulation of cartilage development IMP
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 biological_processGO:0098609 cell-cell adhesion IDA
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0031012 extracellular matrix HDA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008201 heparin binding IBA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IDA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000267 abnormal cardiac development "aberrant formation or incomplete differentiation of the heart" [MGI:cls, J:53370]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0000281 abnormal ventricular septum morphology "abnormality in the wall between the ventricles of the heart, usually incomplete closure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

Allelic Composition: Cyr61tm1Lfl/Cyr61+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000286 abnormal mitral valve morphology "malformation of the valve between the left atrium and the left ventricle of the heart" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:53370]
Show

Allelic Composition: Cyr61tm1Lfl/Cyr61+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0000299 failure of endocardial cushion closure "failure of the mounds of embryonic connective tissue that bulge into the embryonic atrioventricular canal to fuse to form the valves between the right and left atrioventricular orifices" [J:29971]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0001648 abnormal apoptosis "excessive or absent cell death in a particular tissue or cell type" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:25248]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0001711 abnormal placenta 
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0001914 hemorrhage "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0002191 abnormal artery morphology "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Cyr61tm3.1Lfl/Cyr61tm3.1Lfl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0004068 dilated dorsal aorta "an expansion in the volume of the dorsal region of the main trunk of the systemic arteries" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0004225 patent foramen ovale "incomplete closure of the atrial septum after birth, resulting in a flap or a valve-like opening in the atrial septal wall" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyr61tm1Lfl/Cyr61+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0004266 pale placenta "placenta lacking normal reddish coloration, often refers to bloodless condition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0004560 abnormal chorionic plate morphology "any structural anomaly of the portion of the chorion from which chorionic villi develop that establish a connection with the endometrium, giving rise to the fetal portion of the mature placenta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0004787 abnormal dorsal aorta morphology "any structural anomaly of the paired arterial structures of the embryo that supplies each developing somite via efferent segmental arteries; the dorsal aortae articulate with the umbilical arteries, which return mixed blood to the villi of the chorion for reoxygenation" [ISBN:0-914294-08-3 "Gray s Anatomy"]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0005165 increased susceptibility to injury "greater than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mpp3tm1.1Wij/Mpp3tm1.1Wij,Tg(Chx10-EGFP/cre,-ALPP)2Clc/0,Tg(RNU6-RNAi:Mpp5)13Wij/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6JOlaHsd * FVB/N * SJL

Allelic Composition: Cyr61tm3.1Lfl/Cyr61tm3.1Lfl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0006043 decreased apoptosis "less than normal cell death" [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: ApcMin/ApcMin,Ppardtm1.1Rev/Ppardtm1.1Rev
Genetic Background: involves: C57BL/6J

 MP:0008007 abnormal cellular replicative senescence "anomaly in the process in which a cell progresses from its inception to the end of its lifespan, which occurs as the cell continues cycles of growth and division" [GO:0001302, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyr61tm3.1Lfl/Cyr61tm3.1Lfl,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129 * C57BL/6 * DBA

 MP:0008803 abnormal placental labyrinth vasculature morphology "any structural anomaly in blood vessels of the layer of the placenta where embryonic and maternal blood vessels interdigitate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0009657 failure of chorioallantoic fusion "failure to initiate and/or complete the formation of a highly vascularized extra-embryonic fetal membrane by fusion of the chorion and allantois" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0010402 ventricular septal defect "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

Allelic Composition: Cyr61tm1Lfl/Cyr61+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010404 ostium primum atrial septal defect "interatrial communication (atrial septal defect) through the most anterior and inferior aspect of the atrial septum" [http://emedicine.medscape.com, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cyr61tm1Lfl/Cyr61+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010413 complete atrioventricular septal defect "a type of atrioventricular septal defect in which a single atrioventricular valve annulus, a common atrioventricular valve, and a defect of the inlet ventricular septum are observed; deficiency of the atrioventricular septum also results in the presence of a large primum atrial septal defect" [http://emedicine.medscape.com]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

Allelic Composition: Cyr61tm1Lfl/Cyr61+
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0010607 common atrioventricular valve "the presence of a single atrioventricular valve instead of both a mitral and tricuspid valve, most commonly due to incomplete or failure of fetal atrioventricular canal septation" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

 MP:0011108 partial embryonic lethality during organogenesis "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
Show

Allelic Composition: Hrrh-bmh/Hrrh-bmh
Genetic Background: involves: C57BL/6JRj * CBA/JRj

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
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