ENSMUSG00000019997


Mus musculus

Features
Gene ID: ENSMUSG00000019997
  
Biological name :Ctgf
  
Synonyms : Connective tissue growth factor / Ctgf / P29268
  
Possible biological names infered from orthology : P29279
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: A4
Gene start: 24595442
Gene end: 24598683
  
Corresponding Affymetrix probe sets: 10362201 (MoGene1.0st)   1416953_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135212
Ensembl peptide - ENSMUSP00000020171
Ensembl peptide - ENSMUSP00000135147
NCBI entrez gene - 14219     See in Manteia.
MGI - MGI:95537
RefSeq - NM_010217
RefSeq Peptide - NP_034347
swissprot - P29268
swissprot - H3BJW0
swissprot - H3BK14
Ensembl - ENSMUSG00000019997
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ctgfaENSDARG00000042934Danio rerio
 CTGFENSGALG00000037402Gallus gallus
 CTGFENSG00000118523Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Nov / Q64299 / nephroblastoma overexpressed / P48745*ENSMUSG0000003736249
Cyr61 / P18406 / Protein CYR61 / O00622* / cysteine rich angiogenic inducer 61*ENSMUSG0000002819548
Wisp1 / O54775 / WNT1 inducible signaling pathway protein 1 / O95388*ENSMUSG0000000512442
Wisp3 / D3Z5L9 / WNT1 inducible signaling pathway protein 3 / O95389*ENSMUSG0000006207435
Wisp2 / WNT1 inducible signaling pathway protein 2 / O76076*ENSMUSG0000002765630


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR006207  Cystine knot, C-terminal
 IPR006208  Glycoprotein hormone subunit beta
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR012395  IGFBP-related, CNN
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IDA
 biological_processGO:0001503 ossification IMP
 biological_processGO:0001525 angiogenesis IMP
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001894 tissue homeostasis IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007160 cell-matrix adhesion IDA
 biological_processGO:0007229 integrin-mediated signaling pathway IDA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008543 fibroblast growth factor receptor signaling pathway IDA
 biological_processGO:0009749 response to glucose IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0010942 positive regulation of cell death IEA
 biological_processGO:0014070 response to organic cyclic compound IEA
 biological_processGO:0016477 cell migration IDA
 biological_processGO:0030154 cell differentiation IDA
 biological_processGO:0030324 lung development IEA
 biological_processGO:0032330 regulation of chondrocyte differentiation IMP
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0034059 response to anoxia IEA
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0035988 chondrocyte proliferation IMP
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043434 response to peptide hormone IEA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0046330 positive regulation of JNK cascade IEA
 biological_processGO:0050867 positive regulation of cell activation IEA
 biological_processGO:0051385 response to mineralocorticoid IEA
 biological_processGO:0051496 positive regulation of stress fiber assembly IEA
 biological_processGO:0060401 cytosolic calcium ion transport IEA
 biological_processGO:0060452 positive regulation of cardiac muscle contraction IEA
 biological_processGO:0060548 negative regulation of cell death IEA
 biological_processGO:0061448 connective tissue development IMP
 biological_processGO:0070278 extracellular matrix constituent secretion IEA
 biological_processGO:0070318 positive regulation of G0 to G1 transition IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IEA
 biological_processGO:0070542 response to fatty acid IEA
 biological_processGO:0071897 DNA biosynthetic process IEA
 biological_processGO:0072593 reactive oxygen species metabolic process IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001968 fibronectin binding IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000018 small ears "outer ears of a smaller than normal size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0000063 reduced bone density "decreased mineral content of bone; indicator of bone strength" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:57315]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ctgftm1.1Vlcg/Ctgftm1.1Vlcg,Tg(Prrx1-cre)1Cjt/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J * C57BL/6NTac * SJL/J

Allelic Composition: Ctgftm1Mga/Ctgftm1.1Vlcg,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac * FVB/NJ

Allelic Composition: Ctgftm1Mga/Ctgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000088 short mandible "reduced length of the lower bony framework of the mouth where the inferior teeth are held" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0000101 absent ethmoidal bone "missing midline facial bone that encloses the nasal cavity" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:49840]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0000108 midline facial cleft "incomplete merging or fusion of the tissues normally uniting to form the face" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:49840]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tbx2tm2.2Vmc/Tbx2tm2.2Vmc
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * FVB

Allelic Composition: Ctgftm1Mga/Ctgftm1.1Vlcg,Tg(BGLAP-cre)1Clem/0
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac * FVB/NJ

Allelic Composition: Ctgftm1Mga/Ctgf+
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000137 abnormal vertebrae morphology "malformed bony segment of the spinal column" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ctgftm1Mga/Ctgftm1Mga
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000150 abnormal rib morphology "malformed bones forming the bony wall of the chest" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:50311]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0000157 abnormal sternum morphology "malformed long flat bone of the chest; articulates with clavicle and first seven rib pairs" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:19212]
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Allelic Composition: Ctgftm1Mga/Ctgftm1Mga
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000163 abnormal cartilage morphology "anomalous structure or development of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0000164 abnormal cartilage development "anomalous formation of the nonvascular, resilient, flexible connective tissue found primarily in joints, walls of the throax, and tubular structures, but which also comprises most of the skeleton in early fetal life " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0000165 abnormal hypertrophic chondrocyte zone "anomaly of the cartilage cell matrix layer " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0000260 abnormal angiogenesis "aberrant process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctgftm1Mga/Ctgftm1Mga
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0000440 domed skull 
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0000585 kinked tail "a sharp bend or zig-zag in the tail" [J:61295]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0000592 short tail "reduced length of tail compared to control " [J:55583]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0001176 abnormal lung development "malformation or arrest of differentiation of the organs of respiration" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54931]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0001178 pulmonary hypoplasia "reduced size of the respiratory organ due to incomplete development of all or part of the organ " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Pathology , 2nd edition:ISBN 0-397-51047-0]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0001286 abnormal eye development "malformation or arrest of differentiation of the visual organ" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:49840]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

 MP:0001622 abnormal vasculogenesis "aberrant process of the initial establishment of the vascular network " [J:67296, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

 MP:0001953 respiratory failure "cessation of or failure to commence breathing" [MGI:cls, J:60159]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ctgftm1Mga/Ctgftm1Mga
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002114 abnormal axial skeleton morphology "abnormal development of vertebral, spinal or sternal bones resulting in morphological abnormality" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(CAG-cre/Esr1*)5Amc/?
Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

Allelic Composition: Ctgftm1.1Vlcg/Ctgftm1.1Vlcg
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Ctgftm1.1(folA/cre)Hze/Ctgf+
Genetic Background: involves: 129S4/SvJaeSor * 129S6/SvEvTac * C57BL/6 * C57BL/6NCr

 MP:0002270 abnormal alveoli morphology "any structural anomaly of the outpouching of the respiratory system where gas exchange occurs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0002275 abnormal type II pneumocyte morphology "any structural anomaly of the epithelial cells lining the alveoli that produce surfactant " [Pathology , 2nd edition:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0002657 chondrodystrophy "abnormal development of the cartilage primordia of long bones, resulting in abnormally short extremities but normal head and trunk" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ctgftm1Mga/Ctgftm1Mga
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0002981 increased liver weight "a greater than average weight of the bile-secreting exocrine gland" [il:Ira Lu , Mouse Genome Informatics Curator]
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Allelic Composition: Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Wwtr1tm1Hku/Wwtr1tm1Hku,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA

 MP:0003333 liver fibrosis "invasion of fibrous connective tissue into the liver, often resulting from inflammation or injury " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ctgftm1.1Alea/Ctgftm1.1Alea,Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA

 MP:0003408 increased width of hypertrophic chondrocyte zone "increased width of cartilage cell matrix layer " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0003419 delayed endochondral bone ossification "late onset of bone formation in bones that form from cartilage" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:94631]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0003641 small lung "reduced size of the lung relative to normal" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95332]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0003723 abnormal long bone morphology "malformation of any of the several elongated bones of the extremities " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0003743 abnormal facial morphology "anomalous structure or development of the face" [ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0003795 abnormal bone structure 
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0003961 decreased lean body mass "less than average fat-free physical bulk or volume of the body including all its components except adipose tissue" [honda:Hiraoki Onda, Mouse GEnome Informatics Curator]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0004321 short sternum "reduced length of the long flat bone of the chest which articulates with clavicle and first seven rib pairs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004322 abnormal sternebra morphology "any structural anomaly of one segments of the primordial sternum of the embryo; these segments fuse to form the body of the adult vertebrate sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004358 bowed tibia "increased curvature of the medial and larger of the two bones of the lower leg" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004361 bowed ulna "increased curvature of the medial and larger of the two bones of the forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004372 bowed fibula "increased curvature of the lateral and smaller bone of the lower limb" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004374 bowed radius "increased curvature of the short bone of the lateral forearm" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004391 abnormal respiratory conducting tube "any structural anomaly of the tubes of the respiratory system that allows passage of air from the trachea to the alveoli of the lungs" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004607 abnormal cervical atlas morphology "any structural anomaly of the first (topmost, C1) cervical vertebra which supports the globe of the head" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004624 abnormal thoracic cage "any structural anomaly of the bony and cartilaginous structure enclosing the thoracic cavity, consisting of the thoracic vertebrae, ribs, costal cartilages, and sternum" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004703 abnormal vertebral column "any structural anomaly of the complete structure forming the rostral-caudal axis of the skeleton formed from the alternating segments of vertebra and intervertebral discs which support the spinal cord" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004726 abnormal nasal capsule morphology "any structural abnormality in the cartilage around the developing nasal cavity of the embryo" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0004734 small thoracic cavity "reduced size of the cavity in the vertebrate body enclosed by the ribcage between the diaphragm and the neck, and contains the lungs, heart, thoracic aorta, pulmonary artery and its branches, thymus gland, and the respiratory airway" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0005501 abnormal skin physiology "atypical function of the membranous protective covering of the body" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0005587 abnormal Meckel s cartilage morphology "structural anomaly of this cartilage bar in the mandibular arch that forms a temporary supporting structure in the embryonic mandible; gives rise to middle ear bones and sphenomandibular and anterior malleolar ligaments" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:17694]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0005631 decreased lung weight "less than the normal state of the physical heaviness of the lung" [RGD:Rat Genome Database submission]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0006397 disorganized long bone epiphyseal plate "a lack of the regular arrangement of the cells or zones of the epiphyseal plate" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0006398 increased long bone epiphyseal plate size "greater than the normal size of the cartilaginous center of ossification on the long bones permitting growth of the bone in both directions during development" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0008271 abnormal bone ossification "any anomaly in the formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance" [GO:0001503]
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Allelic Composition: Ctgftm1Mga/Ctgftm1Mga
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

 MP:0008797 facial cleft "a cleft resulting from incomplete merging or fusion of any of the embryonic facial processes that normally unite to form the face" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

 MP:0008798 lateral facial cleft "presence of a primitive oral fissure (macrostomia) that extends into the anlage region of the ears, between the 1st and 2nd pharyngeal arches" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Adgra2tm1.2Bstc/Adgra2tm1.2Bstc
Genetic Background: B6.Cg-Adgra2tm1.2Bstc

 MP:0009250 abnormal appendicular skeleton morphology "any structural anomaly of the bones of the limbs, shoulder and pelvic girdles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0009346 decreased cancellous bone thickness "thinner than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0009780 abnormal chondrocyte physiology "any functional anomaly of nondividing cartilage cells" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0009886 failure of palatal shelf elevation "the palatal shelves fail to move from a vertical position in the orofacial cavity to a horizontal apposition above the developing tongue" [PMID:16680722]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0009890 cleft secondary palate "congenital fissure of the tissues normally uniting to form the secondary palate" [PMID:16680722]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0010124 decreased bone mineral content "reduction in the amount (usually in grams/cm) of bone mineral divided by a bone-scanned area" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0010395 abnormal branchial arch development "abnormal formation of the of the transient structures of the embryo that develop into regions of the head, neck and ears" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0010827 small lung saccule "reduced size of the transient dilations of the developing alveolar (or transient) ducts, which transform into a transitory alveolar duct as soon as it develops further branches; the last transitory saccule formed on each pathway is a terminal saccule that develops into an alveolar sac after birth" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0010889 small alveolar lamellar bodies "decreased size of the specialized secretory organelles found in the cytoplasm of type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0011087 complete neonatal lethality "death of all organisms of a given genotype in a population within the neonatal period after birth (Mus: P0)" [MGI:csmith]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

Allelic Composition: Ctgftm1Mga/Ctgftm1Mga
Genetic Background: involves: 129S6/SvEvTac * C57BL/6NTac

Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

Allelic Composition: Ctgftm2Mae/Ctgf+,Tg(EIIa-cre)C5379Lmgd/?
Genetic Background: involves: 129S6/SvEvTac

 MP:0011148 decreased mesenchymal cell proliferation involved in lung development "reduction in the expansion rate of a lung mesenchymal cell population by cell division" [MGI:anna]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0012236 abnormal cholangiocyte morphology "any structural anomaly of the epithelial cells of the bile duct that have primary cilia extending from their apical membrane into the ductal lumen; cholangiocytes are cuboidal epithelium in the small interlobular bile ducts, but become columnar and mucus secreting in larger bile ducts approaching the porta hepatis and the extrahepatic ducts" [PMID:22961800]
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Allelic Composition: Ctgftm1.1Alea/Ctgftm1.1Alea,Mob1atm1.1Asuz/Mob1atm1.1Asuz,Mob1bGt(CC0690)Wtsi/Mob1bGt(CC0690)Wtsi,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * DBA

 MP:0012514 pectus excavatum "a caved-in or sunken appearance of the anterior chest wall; the congenital deformity can either be present at birth or may not be visible until puberty" [MGI:anna]
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Allelic Composition: Gpx4tm1Yana/Gpx4tm1Yana
Genetic Background: involves: C57BL/6 * CBA

 MP:0030066 short face "an abnormally decreased height (length) of the face" [MGI:anna]
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Allelic Composition: Ctgftm1Mae/Ctgftm1Mae
Genetic Background: 129S6/SvEvTac-Ctgftm1Mae

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

1 s.

 
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