ENSMUSG00000062074


Mus musculus

Features
Gene ID: ENSMUSG00000062074
  
Biological name :Wisp3
  
Synonyms : D3Z5L9 / Wisp3 / WNT1 inducible signaling pathway protein 3
  
Possible biological names infered from orthology : O95389
  
Species: Mus musculus
  
Chr. number: 10
Strand: -1
Band: B1
Gene start: 39150970
Gene end: 39163794
  
Corresponding Affymetrix probe sets: 10368689 (MoGene1.0st)   1444050_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000076003
NCBI entrez gene - 327743     See in Manteia.
MGI - MGI:2685581
RefSeq - NM_001127376
RefSeq Peptide - NP_001120848
swissprot - D3Z5L9
Ensembl - ENSMUSG00000062074
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 wisp3ENSDARG00000071048Danio rerio
 ENSGALG00000019934Gallus gallus
 WISP3ENSG00000112761Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Wisp1 / O54775 / WNT1 inducible signaling pathway protein 1 / O95388*ENSMUSG0000000512441
Ctgf / P29268 / Connective tissue growth factor / P29279*ENSMUSG0000001999734
Cyr61 / P18406 / Protein CYR61 / O00622* / cysteine rich angiogenic inducer 61*ENSMUSG0000002819533
Nov / Q64299 / nephroblastoma overexpressed / P48745*ENSMUSG0000003736232
Wisp2 / WNT1 inducible signaling pathway protein 2 / O76076*ENSMUSG0000002765623


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR006207  Cystine knot, C-terminal
 IPR006208  Glycoprotein hormone subunit beta
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR012395  IGFBP-related, CNN
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008285 negative regulation of cell proliferation ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis ISO
 biological_processGO:0060548 negative regulation of cell death IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 molecular_functionGO:0005178 integrin binding IBA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA
 molecular_functionGO:0008201 heparin binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000627 abnormal mammary gland morphology "malformation of the milk-secreting gland that lies within the breast; usually rudimentary in males" [J:70183]
Show

Allelic Composition: Fkrptvrm53/Fkrptvrm53
Genetic Background: C57BL/6J-Fkrptvrm53/Pjn

 MP:0001272 increased metastatic potential 
Show

Allelic Composition: Fkrptvrm53/Fkrptvrm53
Genetic Background: C57BL/6J-Fkrptvrm53/Pjn

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0001883 mammary adenocarcinoma "higher than normal incidence of malignant tumors of the mammary gland" [J:62919]
Show

Allelic Composition: Fkrptvrm53/Fkrptvrm53
Genetic Background: C57BL/6J-Fkrptvrm53/Pjn

Allelic Composition: Tg(MMTV-cre)1Mam/0,Tg(MMTV-PyVT)634Mul/0,Wisp3tm1.1Cgkl/Wisp3tm1.1Cgkl
Genetic Background: FVB/N-Wisp3tm1.1Cgkl Tg(MMTV-cre)1Mam Tg(MMTV-PyVT)634Mul

 MP:0001885 mammary ductal hyperplasia 
Show

Allelic Composition: Fkrptvrm53/Fkrptvrm53
Genetic Background: C57BL/6J-Fkrptvrm53/Pjn

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cdh2Gt(OST49160)Lex/Cdh2Gt(OST49160)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Wisp3tm1(cre)Mawa/Wisp3tm1(cre)Mawa
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Wisp3tm2Mawa/Wisp3tm2Mawa
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0006271 abnormal involution of the mammary gland "anomaly in the process during which mammary glands suspend milk protein production, the mammary alveolar structures collapse and secretory epithelial cells are lost" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fkrptvrm53/Fkrptvrm53
Genetic Background: C57BL/6J-Fkrptvrm53/Pjn

 MP:0009503 abnormal mammary gland duct morphology "any structural anomaly of the canals that lead from the lobes of the mammary gland to the tip of the nipple and are responsible for carrying milk toward the nipple in a lactating female" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fkrptvrm53/Fkrptvrm53
Genetic Background: C57BL/6J-Fkrptvrm53/Pjn

 MP:0013782 abnormal mammary duct terminal end bud morphology "any structural anomaly of the unique club-shaped epithelial structure that develops at the tip of the mammary duct at the onset of puberty (approximately 3 weeks of age in mouse) under the action of circulating hormones; terminal end buds (TEBs) consist of an outer layer of undifferentiated myoepithelial progenitor cells (cap cells), and a multilayered inner core of luminal epithelial cells (body) fated to form the walls of the ductal lumen; both layers have high rates of mitosis, consistent with a motile organ dedicated to ductal morphogenesis; TEBs proliferate, ramify, and actively invade the fad pad to allow the formation of a complex branching structure; this process of branching morphogenesis concludes at about 10-12 weeks of age in mouse, when TEBs have traversed the length of the fat pad and a fully developed ductal tree has formed" [MGI:Anna, PMID:16280048, PMID:16916375, PMID:18296651]
Show

Allelic Composition: Fkrptvrm53/Fkrptvrm53
Genetic Background: C57BL/6J-Fkrptvrm53/Pjn

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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