ENSG00000142871


Homo sapiens

Features
Gene ID: ENSG00000142871
  
Biological name :CYR61
  
Synonyms : CYR61 / cysteine rich angiogenic inducer 61 / O00622
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p22.3
Gene start: 85580761
Gene end: 85583962
  
Corresponding Affymetrix probe sets: 201289_at (Human Genome U133 Plus 2.0 Array)   210764_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398736
NCBI entrez gene - 3491     See in Manteia.
OMIM - 602369
RefSeq - NM_001554
RefSeq Peptide - NP_001545
swissprot - O00622
swissprot - Q6FI18
Ensembl - ENSG00000142871
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cyr61ENSDARG00000023062Danio rerio
 CYR61ENSGALG00000008661Gallus gallus
 Cyr61ENSMUSG00000028195Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CTGF / P29279 / connective tissue growth factorENSG0000011852342
NOV / P48745 / nephroblastoma overexpressedENSG0000013699940
WISP1 / O95388 / WNT1 inducible signaling pathway protein 1ENSG0000010441535
WISP3 / O95389 / WNT1 inducible signaling pathway protein 3ENSG0000011276131
WISP2 / O76076 / WNT1 inducible signaling pathway protein 2ENSG0000006420525


Protein motifs (from Interpro)
Interpro ID Name
 IPR000867  Insulin-like growth factor-binding protein, IGFBP
 IPR000884  Thrombospondin type-1 (TSP1) repeat
 IPR001007  VWFC domain
 IPR006207  Cystine knot, C-terminal
 IPR006208  Glycoprotein hormone subunit beta
 IPR009030  Growth factor receptor cysteine-rich domain superfamily
 IPR012395  IGFBP-related, CNN
 IPR017891  Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
 IPR036383  Thrombospondin type-1 (TSP1) repeat superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001558 regulation of cell growth IEA
 biological_processGO:0001649 osteoblast differentiation IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002041 intussusceptive angiogenesis IEA
 biological_processGO:0003181 atrioventricular valve morphogenesis IEA
 biological_processGO:0003278 apoptotic process involved in heart morphogenesis IEA
 biological_processGO:0003281 ventricular septum development IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0007155 cell adhesion IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008283 cell proliferation TAS
 biological_processGO:0009653 anatomical structure morphogenesis TAS
 biological_processGO:0010518 positive regulation of phospholipase activity IEA
 biological_processGO:0010811 positive regulation of cell-substrate adhesion IEA
 biological_processGO:0030198 extracellular matrix organization IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030513 positive regulation of BMP signaling pathway IGI
 biological_processGO:0033690 positive regulation of osteoblast proliferation IDA
 biological_processGO:0043065 positive regulation of apoptotic process IEA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043280 positive regulation of cysteine-type endopeptidase activity involved in apoptotic process IEA
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 biological_processGO:0044319 wound healing, spreading of cells IDA
 biological_processGO:0045597 positive regulation of cell differentiation IEA
 biological_processGO:0045669 positive regulation of osteoblast differentiation IDA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060413 atrial septum morphogenesis IEA
 biological_processGO:0060548 negative regulation of cell death IBA
 biological_processGO:0060591 chondroblast differentiation IEA
 biological_processGO:0060710 chorio-allantoic fusion IEA
 biological_processGO:0060716 labyrinthine layer blood vessel development IEA
 biological_processGO:0061036 positive regulation of cartilage development IEA
 biological_processGO:0070372 regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0072593 reactive oxygen species metabolic process IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 biological_processGO:2000304 positive regulation of ceramide biosynthetic process IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0031012 extracellular matrix HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005520 insulin-like growth factor binding IEA
 molecular_functionGO:0008201 heparin binding IBA
 molecular_functionGO:0019838 growth factor binding IEA
 molecular_functionGO:0050840 extracellular matrix binding IEA


Pathways (from Reactome)
Pathway description
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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