ENSG00000137312


Homo sapiens

Features
Gene ID: ENSG00000137312
  
Biological name :FLOT1
  
Synonyms : FLOT1 / flotillin 1 / O75955
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: p21.33
Gene start: 30727709
Gene end: 30742733
  
Corresponding Affymetrix probe sets: 208748_s_at (Human Genome U133 Plus 2.0 Array)   208749_x_at (Human Genome U133 Plus 2.0 Array)   210142_x_at (Human Genome U133 Plus 2.0 Array)   213819_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000365569
Ensembl peptide - ENSP00000412058
Ensembl peptide - ENSP00000404300
Ensembl peptide - ENSP00000400615
Ensembl peptide - ENSP00000398834
Ensembl peptide - ENSP00000395333
Ensembl peptide - ENSP00000391341
NCBI entrez gene - 10211     See in Manteia.
OMIM - 606998
RefSeq - XM_017010158
RefSeq - NM_001318875
RefSeq - NM_005803
RefSeq - XM_005248780
RefSeq - XM_006714947
RefSeq - XM_017010157
RefSeq Peptide - NP_001305804
RefSeq Peptide - NP_005794
swissprot - O75955
swissprot - A2AB12
swissprot - A2AB11
swissprot - A2AB10
swissprot - A2AB09
swissprot - Q5ST80
swissprot - A2AB13
swissprot - A2ABJ5
Ensembl - ENSG00000137312
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flot1aENSDARG00000001710Danio rerio
 flot1bENSDARG00000037998Danio rerio
 Flot1ENSMUSG00000059714Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FLOT2 / Q14254 / flotillin 2ENSG0000013258945


Protein motifs (from Interpro)
Interpro ID Name
 IPR001107  Band 7 domain
 IPR027705  Flotillin family
 IPR031905  Flotillin, C-terminal domain
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001765 membrane raft assembly IMP
 biological_processGO:0001819 positive regulation of cytokine production IMP
 biological_processGO:0001934 positive regulation of protein phosphorylation IMP
 biological_processGO:0002090 regulation of receptor internalization IMP
 biological_processGO:0007409 axonogenesis IEA
 biological_processGO:0022617 extracellular matrix disassembly IMP
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IEA
 biological_processGO:0032728 positive regulation of interferon-beta production IMP
 biological_processGO:0033227 dsRNA transport IMP
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IMP
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IMP
 biological_processGO:0034976 response to endoplasmic reticulum stress IMP
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0044854 plasma membrane raft assembly IMP
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IMP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0051260 protein homooligomerization IMP
 biological_processGO:0060355 positive regulation of cell adhesion molecule production IMP
 biological_processGO:0070528 protein kinase C signaling IMP
 biological_processGO:0071360 cellular response to exogenous dsRNA IMP
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IEA
 biological_processGO:1901890 positive regulation of cell junction assembly IMP
 biological_processGO:1903044 protein localization to membrane raft IMP
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IMP
 cellular_componentGO:0001931 uropod IDA
 cellular_componentGO:0005765 lysosomal membrane HDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005769 early endosome IDA
 cellular_componentGO:0005815 microtubule organizing center IDA
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0005901 caveola TAS
 cellular_componentGO:0005911 cell-cell junction IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0008180 COP9 signalosome IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016600 flotillin complex IEA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0034451 centriolar satellite IDA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0044853 plasma membrane raft IEA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IMP


Pathways (from Reactome)
Pathway description
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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