ENSMUSG00000059714


Mus musculus

Features
Gene ID: ENSMUSG00000059714
  
Biological name :Flot1
  
Synonyms : Flot1 / Flotillin-1 / O08917
  
Possible biological names infered from orthology : O75955
  
Species: Mus musculus
  
Chr. number: 17
Strand: 1
Band: B1
Gene start: 35823230
Gene end: 35832791
  
Corresponding Affymetrix probe sets: 10444895 (MoGene1.0st)   1448559_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000134699
Ensembl peptide - ENSMUSP00000001569
Ensembl peptide - ENSMUSP00000133289
Ensembl peptide - ENSMUSP00000133454
Ensembl peptide - ENSMUSP00000134227
Ensembl peptide - ENSMUSP00000134681
NCBI entrez gene - 14251     See in Manteia.
MGI - MGI:1100500
RefSeq - XM_006523657
RefSeq - NM_008027
RefSeq - XM_006523656
RefSeq Peptide - NP_032053
swissprot - G3UWW8
swissprot - G3UYU4
swissprot - Q540I4
swissprot - G3UZZ5
swissprot - G3XA73
swissprot - O08917
Ensembl - ENSMUSG00000059714
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flot1aENSDARG00000001710Danio rerio
 flot1bENSDARG00000037998Danio rerio
 FLOT1ENSG00000137312Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flot2 / Q60634 / Flotillin-2 / Q14254*ENSMUSG0000006198146


Protein motifs (from Interpro)
Interpro ID Name
 IPR001107  Band 7 domain
 IPR027705  Flotillin family
 IPR031905  Flotillin, C-terminal domain
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001765 membrane raft assembly IEA
 biological_processGO:0001819 positive regulation of cytokine production IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IEA
 biological_processGO:0002090 regulation of receptor internalization IMP
 biological_processGO:0006897 endocytosis ISO
 biological_processGO:0007409 axonogenesis IMP
 biological_processGO:0007411 axon guidance ISO
 biological_processGO:0022617 extracellular matrix disassembly IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0032226 positive regulation of synaptic transmission, dopaminergic IMP
 biological_processGO:0032728 positive regulation of interferon-beta production IEA
 biological_processGO:0033227 dsRNA transport IEA
 biological_processGO:0034116 positive regulation of heterotypic cell-cell adhesion IEA
 biological_processGO:0034141 positive regulation of toll-like receptor 3 signaling pathway IEA
 biological_processGO:0034976 response to endoplasmic reticulum stress IEA
 biological_processGO:0035023 regulation of Rho protein signal transduction IMP
 biological_processGO:0044854 plasma membrane raft assembly IEA
 biological_processGO:0045807 positive regulation of endocytosis IEA
 biological_processGO:0048643 positive regulation of skeletal muscle tissue development IMP
 biological_processGO:0050821 protein stabilization IEA
 biological_processGO:0051260 protein homooligomerization IEA
 biological_processGO:0060355 positive regulation of cell adhesion molecule production IEA
 biological_processGO:0070528 protein kinase C signaling IMP
 biological_processGO:0071360 cellular response to exogenous dsRNA IEA
 biological_processGO:0072659 protein localization to plasma membrane IEA
 biological_processGO:1901741 positive regulation of myoblast fusion IMP
 biological_processGO:1901890 positive regulation of cell junction assembly IMP
 biological_processGO:1903044 protein localization to membrane raft IEA
 biological_processGO:2000049 positive regulation of cell-cell adhesion mediated by cadherin IMP
 cellular_componentGO:0001931 uropod IEA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005769 early endosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005913 cell-cell adherens junction IEA
 cellular_componentGO:0008180 COP9 signalosome IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016600 flotillin complex IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0030864 cortical actin cytoskeleton IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034451 centriolar satellite IEA
 cellular_componentGO:0042383 sarcolemma IDA
 cellular_componentGO:0042470 melanosome IEA
 cellular_componentGO:0044291 cell-cell contact zone IEA
 cellular_componentGO:0044853 plasma membrane raft IDA
 cellular_componentGO:0045121 membrane raft ISO
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrm3Btlr/Tyrm3Btlr
Genetic Background: involves: C57BL/6J

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Tyrm3Btlr/Tyrm3Btlr
Genetic Background: involves: C57BL/6J

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: C57BL/6J

Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Flot2Gt(258D8)Cmhd/Flot2Gt(258D8)Cmhd,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J

 MP:0008719 impaired neutrophil recruitment "reduced diffusion or accumulation of neutrophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrm3Btlr/Tyrm3Btlr
Genetic Background: involves: C57BL/6J

 MP:0008720 impaired neutrophil migration "defect in the ability of neutrophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Tyrm3Btlr/Tyrm3Btlr
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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