ENSMUSG00000061981


Mus musculus

Features
Gene ID: ENSMUSG00000061981
  
Biological name :Flot2
  
Synonyms : Flot2 / Flotillin-2 / Q60634
  
Possible biological names infered from orthology : Q14254
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: B5
Gene start: 78037931
Gene end: 78060434
  
Corresponding Affymetrix probe sets: 10379013 (MoGene1.0st)   1417544_a_at (Mouse Genome 430 2.0 Array)   1438164_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000072136
Ensembl peptide - ENSMUSP00000073342
Ensembl peptide - ENSMUSP00000098347
Ensembl peptide - ENSMUSP00000133147
NCBI entrez gene - 14252     See in Manteia.
MGI - MGI:103309
RefSeq - XM_006532194
RefSeq - NM_001040403
RefSeq - NM_001284227
RefSeq - NM_001284228
RefSeq - NM_008028
RefSeq - XM_006532191
RefSeq - XM_006532192
RefSeq - XM_006532193
RefSeq Peptide - NP_001035493
RefSeq Peptide - NP_001271156
RefSeq Peptide - NP_001271157
RefSeq Peptide - NP_032054
swissprot - E9PV09
swissprot - Q5SS83
swissprot - Q60634
Ensembl - ENSMUSG00000061981
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flot2aENSDARG00000004830Danio rerio
 flot2bENSDARG00000069774Danio rerio
 FLOT2ENSGALG00000031216Gallus gallus
 FLOT2ENSG00000132589Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Flot1 / O08917 / Flotillin-1 / O75955*ENSMUSG0000005971446


Protein motifs (from Interpro)
Interpro ID Name
 IPR001107  Band 7 domain
 IPR027705  Flotillin family
 IPR031905  Flotillin, C-terminal domain
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001765 membrane raft assembly ISO
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0010629 negative regulation of gene expression ISO
 biological_processGO:0044860 protein localization to plasma membrane raft ISO
 biological_processGO:0045661 regulation of myoblast differentiation IEP
 biological_processGO:0050821 protein stabilization ISO
 biological_processGO:0072659 protein localization to plasma membrane ISO
 biological_processGO:1902992 negative regulation of amyloid precursor protein catabolic process ISO
 biological_processGO:1903905 positive regulation of establishment of T cell polarity ISO
 cellular_componentGO:0001931 uropod ISO
 cellular_componentGO:0002080 acrosomal membrane IDA
 cellular_componentGO:0005768 endosome ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005901 caveola ISO
 cellular_componentGO:0005913 cell-cell adherens junction ISO
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016323 basolateral plasma membrane ISO
 cellular_componentGO:0016600 flotillin complex ISO
 cellular_componentGO:0030027 lamellipodium ISO
 cellular_componentGO:0030139 endocytic vesicle ISS
 cellular_componentGO:0030864 cortical actin cytoskeleton ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0031982 vesicle ISO
 cellular_componentGO:0044291 cell-cell contact zone ISO
 cellular_componentGO:0045121 membrane raft IDA
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISO
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity ISO


Pathways (from Reactome)
Pathway description
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000358 abnormal cell content/ morphology "structural anomalies of the minute protoplasmic masses that make up organized tissues and which are the fundamental structural and functional units of living organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Genetic Background: B6.129-Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo

 MP:0001273 decreased metastatic potential 
Show

Allelic Composition: Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Genetic Background: B6.129-Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Genetic Background: B6.129-Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Flot1tm1.1Arte/Flot1tm1.1Arte,Tg(Thy1-APPSw,Thy1-PSEN1*L166P)21Jckr/?
Genetic Background: involves: C57BL/6J

 MP:0010299 increased mammary gland tumor incidence "greater than the expected number of neoplasms in the mammary gland, usually in the form of a distinct mass, in a specific population in a given time period" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo/Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo
Genetic Background: B6.129-Gt(ROSA)26Sortm1(LRRK2*R1441C)Djmo

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000036957 Lrfn3 / Q8BLY3 / Leucine-rich repeat and fibronectin type-III domain-containing protein 3 / Q9BTN0* / leucine rich repeat and fibronectin type III domain containing 3*  / reaction / complex






 

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