ENSG00000132589


Homo sapiens

Features
Gene ID: ENSG00000132589
  
Biological name :FLOT2
  
Synonyms : FLOT2 / flotillin 2 / Q14254
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: -1
Band: q11.2
Gene start: 28879335
Gene end: 28897679
  
Corresponding Affymetrix probe sets: 201350_at (Human Genome U133 Plus 2.0 Array)   211299_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000463503
Ensembl peptide - ENSP00000463304
Ensembl peptide - ENSP00000465022
Ensembl peptide - ENSP00000465819
Ensembl peptide - ENSP00000378366
Ensembl peptide - ENSP00000378368
NCBI entrez gene - 2319     See in Manteia.
OMIM - 131560
RefSeq - XM_017024396
RefSeq - NM_001330170
RefSeq - NM_004475
RefSeq - XM_005257950
RefSeq - XM_005257953
RefSeq - XM_017024394
RefSeq - XM_017024395
RefSeq Peptide - NP_001317099
RefSeq Peptide - NP_004466
swissprot - J3QKZ4
swissprot - J3QLD9
swissprot - K7EJ47
swissprot - K7EKW9
swissprot - A0A024QZ62
swissprot - Q14254
swissprot - E7EMK3
Ensembl - ENSG00000132589
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 flot2aENSDARG00000004830Danio rerio
 flot2bENSDARG00000069774Danio rerio
 FLOT2ENSGALG00000031216Gallus gallus
 Flot2ENSMUSG00000061981Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
FLOT1 / O75955 / flotillin 1ENSG0000013731245


Protein motifs (from Interpro)
Interpro ID Name
 IPR001107  Band 7 domain
 IPR027705  Flotillin family
 IPR031905  Flotillin, C-terminal domain
 IPR036013  Band 7/SPFH domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001765 membrane raft assembly IMP
 biological_processGO:0007155 cell adhesion NAS
 biological_processGO:0008544 epidermis development TAS
 biological_processGO:0010629 negative regulation of gene expression IMP
 biological_processGO:0044860 protein localization to plasma membrane raft IMP
 biological_processGO:0045661 regulation of myoblast differentiation IEP
 biological_processGO:0050821 protein stabilization IMP
 biological_processGO:0072659 protein localization to plasma membrane IMP
 biological_processGO:1902992 negative regulation of amyloid precursor protein catabolic process IMP
 biological_processGO:1903905 positive regulation of establishment of T cell polarity IMP
 cellular_componentGO:0001931 uropod IDA
 cellular_componentGO:0002080 acrosomal membrane IEA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane NAS
 cellular_componentGO:0005901 caveola IDA
 cellular_componentGO:0005913 cell-cell adherens junction IDA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016600 flotillin complex IDA
 cellular_componentGO:0030027 lamellipodium IDA
 cellular_componentGO:0030139 endocytic vesicle IDA
 cellular_componentGO:0030864 cortical actin cytoskeleton IDA
 cellular_componentGO:0031410 cytoplasmic vesicle IDA
 cellular_componentGO:0031982 vesicle IDA
 cellular_componentGO:0044291 cell-cell contact zone IDA
 cellular_componentGO:0045121 membrane raft IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0002020 protease binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0035255 ionotropic glutamate receptor binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IMP


Pathways (from Reactome)
Pathway description
Synaptic adhesion-like molecules


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000126243 LRFN3 / Q9BTN0 / leucine rich repeat and fibronectin type III domain containing 3  / reaction / complex






 

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