ENSG00000137880


Homo sapiens

Features
Gene ID: ENSG00000137880
  
Biological name :GCHFR
  
Synonyms : GCHFR / GTP cyclohydrolase I feedback regulator / P30047
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q15.1
Gene start: 40764020
Gene end: 40767710
  
Corresponding Affymetrix probe sets: 204867_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000454067
Ensembl peptide - ENSP00000477896
Ensembl peptide - ENSP00000454195
Ensembl peptide - ENSP00000260447
Ensembl peptide - ENSP00000453640
Ensembl peptide - ENSP00000453871
NCBI entrez gene - 2644     See in Manteia.
OMIM - 602437
RefSeq - NM_005258
RefSeq Peptide - NP_005249
swissprot - P30047
swissprot - H0YNX7
swissprot - H0YNM1
swissprot - A0A087WTI4
Ensembl - ENSG00000137880
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gchfrENSDARG00000098588Danio rerio
 GCHFRENSGALG00000032239Gallus gallus
 GchfrENSMUSG00000046814Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR009112  GTP cyclohydrolase I, feedback regulatory protein
 IPR036717  GFRP superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006809 nitric oxide biosynthetic process TAS
 biological_processGO:0009890 negative regulation of biosynthetic process IEA
 biological_processGO:0042133 neurotransmitter metabolic process TAS
 biological_processGO:0043105 negative regulation of GTP cyclohydrolase I activity IEA
 biological_processGO:0051186 cofactor metabolic process TAS
 biological_processGO:0051291 protein heterooligomerization IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0031965 nuclear membrane IEA
 cellular_componentGO:0042470 melanosome IDA
 molecular_functionGO:0004857 enzyme inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016597 amino acid binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0019899 enzyme binding IEA
 molecular_functionGO:0030742 GTP-dependent protein binding IEA
 molecular_functionGO:0044549 GTP cyclohydrolase binding IEA


Pathways (from Reactome)
Pathway description
Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000137880 GCHFR / P30047 / GTP cyclohydrolase I feedback regulator  / reaction / complex
 ENSG00000131979 GCH1 / P30793 / GTP cyclohydrolase 1  / reaction / complex






 

1 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr