ENSG00000138073


Homo sapiens

Features
Gene ID: ENSG00000138073
  
Biological name :PREB
  
Synonyms : PREB / prolactin regulatory element binding / Q9HCU5
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: -1
Band: p23.3
Gene start: 27130756
Gene end: 27134675
  
Corresponding Affymetrix probe sets: 217861_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000407036
Ensembl peptide - ENSP00000397036
Ensembl peptide - ENSP00000416103
Ensembl peptide - ENSP00000260643
Ensembl peptide - ENSP00000384032
Ensembl peptide - ENSP00000391894
NCBI entrez gene - 10113     See in Manteia.
OMIM - 606395
RefSeq - XM_011532472
RefSeq - NM_001330484
RefSeq - NM_001330485
RefSeq - NM_013388
RefSeq - XM_006711914
RefSeq - XM_011532471
RefSeq Peptide - NP_001317413
RefSeq Peptide - NP_001317414
RefSeq Peptide - NP_037520
swissprot - H7BZX0
swissprot - H7C0W3
swissprot - H7C2N7
swissprot - F8WCS5
swissprot - B5MC98
swissprot - Q9HCU5
Ensembl - ENSG00000138073
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prebENSDARG00000101602Danio rerio
 PREBENSGALG00000029369Gallus gallus
 PrebENSMUSG00000045302Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR011047  Quinoprotein alcohol dehydrogenase-like superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR036322  WD40-repeat-containing domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003400 regulation of COPII vesicle coating IBA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0009306 protein secretion IBA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016192 vesicle-mediated transport IEA
 biological_processGO:0032527 protein exit from endoplasmic reticulum IMP
 biological_processGO:0036498 IRE1-mediated unfolded protein response TAS
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0048208 COPII vesicle coating ISS
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030176 integral component of endoplasmic reticulum membrane ISS
 cellular_componentGO:0070971 endoplasmic reticulum exit site IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005090 Sar guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IBA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0051020 GTPase binding IEA


Pathways (from Reactome)
Pathway description
COPII-mediated vesicle transport
XBP1(S) activates chaperone genes
Cargo concentration in the ER


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000152700 SAR1B / Q9Y6B6 / secretion associated Ras related GTPase 1B  / reaction
 ENSG00000100934 Q15436 / SEC23A / Sec23 homolog A, coat complex II component  / reaction / complex
 ENSG00000154305 MIA3 / Q5JRA6 / MIA family member 3, ER export factor  / reaction / complex
 ENSG00000176986 P53992 / SEC24C / SEC24 homolog C, COPII coat complex component  / reaction / complex
 ENSG00000150527 CTAGE5 / O15320 / Q96PC5 / CTAGE family member 5, ER export factor  / complex / reaction






 

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