ENSG00000140263


Homo sapiens

Features
Gene ID: ENSG00000140263
  
Biological name :SORD
  
Synonyms : Q00796 / sorbitol dehydrogenase / SORD
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 15
Strand: 1
Band: q21.1
Gene start: 45023104
Gene end: 45077185
  
Corresponding Affymetrix probe sets: 201562_s_at (Human Genome U133 Plus 2.0 Array)   201563_at (Human Genome U133 Plus 2.0 Array)   230782_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000453904
Ensembl peptide - ENSP00000267814
Ensembl peptide - ENSP00000452731
Ensembl peptide - ENSP00000453122
NCBI entrez gene - 6652     See in Manteia.
OMIM - 182500
RefSeq - NM_003104
RefSeq Peptide - NP_003095
swissprot - H0YKB3
swissprot - H0YLA4
swissprot - Q00796
Ensembl - ENSG00000140263
  
Related genetic diseases (OMIM): 182500 - ?Cataract, congenital
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sordENSDARG00000053405Danio rerio
 SORDENSGALG00000031408Gallus gallus
 SordENSMUSG00000027227Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002328  Alcohol dehydrogenase, zinc-type, conserved site
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013154  Alcohol dehydrogenase, N-terminal
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006006 glucose metabolic process TAS
 biological_processGO:0006060 sorbitol metabolic process IEA
 biological_processGO:0006062 sorbitol catabolic process IDA
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0019640 glucuronate catabolic process to xylulose 5-phosphate TAS
 biological_processGO:0030317 flagellated sperm motility NAS
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046370 fructose biosynthetic process IDA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0051160 L-xylitol catabolic process IDA
 biological_processGO:0051164 L-xylitol metabolic process IDA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031514 motile cilium ISS
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome IDA
 molecular_functionGO:0003939 L-iditol 2-dehydrogenase activity EXP
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0030246 carbohydrate binding NAS
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0046526 D-xylulose reductase activity EXP
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IDA


Pathways (from Reactome)
Pathway description
Fructose biosynthesis
Formation of xylulose-5-phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000140263 SORD / Q00796 / sorbitol dehydrogenase  / complex






 

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