ENSMUSG00000027227


Mus musculus

Features
Gene ID: ENSMUSG00000027227
  
Biological name :Sord
  
Synonyms : Q64442 / sorbitol dehydrogenase / Sord
  
Possible biological names infered from orthology : Q00796
  
Species: Mus musculus
  
Chr. number: 2
Strand: 1
Band: E5
Gene start: 122234749
Gene end: 122265340
  
Corresponding Affymetrix probe sets: 10358894 (MoGene1.0st)   10475437 (MoGene1.0st)   1426584_a_at (Mouse Genome 430 2.0 Array)   1438183_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000106180
NCBI entrez gene - 20322     See in Manteia.
MGI - MGI:98266
RefSeq - NM_146126
RefSeq Peptide - NP_666238
swissprot - Q64442
Ensembl - ENSMUSG00000027227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 sordENSDARG00000053405Danio rerio
 SORDENSGALG00000031408Gallus gallus
 SORDENSG00000140263Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002328  Alcohol dehydrogenase, zinc-type, conserved site
 IPR011032  GroES-like superfamily
 IPR013149  Alcohol dehydrogenase, C-terminal
 IPR013154  Alcohol dehydrogenase, N-terminal
 IPR020843  Polyketide synthase, enoylreductase domain
 IPR036291  NAD(P)-binding domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006060 sorbitol metabolic process IDA
 biological_processGO:0006062 sorbitol catabolic process IEA
 biological_processGO:0006970 response to osmotic stress IEA
 biological_processGO:0009725 response to hormone IEA
 biological_processGO:0030317 flagellated sperm motility IDA
 biological_processGO:0031667 response to nutrient levels IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0046370 fructose biosynthetic process IEA
 biological_processGO:0046686 response to cadmium ion IEA
 biological_processGO:0046688 response to copper ion IEA
 biological_processGO:0051160 L-xylitol catabolic process IEA
 biological_processGO:0051164 L-xylitol metabolic process IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0031966 mitochondrial membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0003939 L-iditol 2-dehydrogenase activity ISO
 molecular_functionGO:0008270 zinc ion binding ISO
 molecular_functionGO:0016491 oxidoreductase activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0046526 D-xylulose reductase activity ISO
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0051287 NAD binding IEA


Pathways (from Reactome)
Pathway description
Fructose biosynthesis
Formation of xylulose-5-phosphate


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Hoxa3tm3Mrc/Hoxa3tm3Mrc,Hoxd3tm2Mrc/Hoxd3tm2Mrc
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Relnrl-4J/Relnrl-4J
Genetic Background: B6.Cg-Relnrl-4J/GrsrJ

Allelic Composition: SordC57BL/Lia/SordC57BL/Lia,Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch
Genetic Background: involves: C57BL * CBA

Allelic Composition: SordC57BL/Lia/SordC57BL/Lia,Tg(Cryaa-AKR1B1)648Smch/0
Genetic Background: involves: C57BL * CBA

Allelic Composition: SordC57BL/Lia/Sord+,Tg(Cryaa-AKR1B1)648Smch/0
Genetic Background: involves: C57BL * CBA

Allelic Composition: SordC57BL/Lia/SordC57BL/Lia
Genetic Background: involves: C57BL/LiA

Allelic Composition: Gpx1tm1Ysh/Gpx1tm1Ysh,SordC57BL/Lia/SordC57BL/Lia
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/LiA

 MP:0001764 abnormal homeostasis "anomaly in the state of equilibrium in the body with respect to various functions and to chemical composition of the fluids and tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Relnrl-4J/Relnrl-4J
Genetic Background: B6.Cg-Relnrl-4J/GrsrJ

Allelic Composition: SordC57BL/Lia/SordC57BL/Lia,Tg(Cryaa-AKR1B1)648Smch/Tg(Cryaa-AKR1B1)648Smch
Genetic Background: involves: C57BL * CBA

Allelic Composition: SordC57BL/Lia/SordC57BL/Lia,Tg(Cryaa-AKR1B1)648Smch/0
Genetic Background: involves: C57BL * CBA

Allelic Composition: SordC57BL/Lia/Sord+,Tg(Cryaa-AKR1B1)648Smch/0
Genetic Background: involves: C57BL * CBA

Allelic Composition: SordC57BL/Lia/Sord+,Tg(Cryaa-AKR1B1)222Smch/0
Genetic Background: involves: C57BL * CBA

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Nkrftm1.1Hjh/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000027227 Sord / Q64442 / sorbitol dehydrogenase / Q00796*  / complex






 

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