ENSG00000141052


Homo sapiens

Features
Gene ID: ENSG00000141052
  
Biological name :MYOCD
  
Synonyms : myocardin / MYOCD / Q8IZQ8
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: p12
Gene start: 12665890
Gene end: 12768949
  
Corresponding Affymetrix probe sets: 229339_at (Human Genome U133 Plus 2.0 Array)   237206_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000341835
Ensembl peptide - ENSP00000400148
Ensembl peptide - ENSP00000401678
Ensembl peptide - ENSP00000462694
NCBI entrez gene - 93649     See in Manteia.
OMIM - 606127
RefSeq - XM_017025342
RefSeq - NM_001146312
RefSeq - NM_153604
RefSeq - XM_005256863
RefSeq - XM_005256864
RefSeq Peptide - NP_001139784
RefSeq Peptide - NP_705832
swissprot - Q6N065
swissprot - Q8IZQ8
swissprot - J3KSX3
Ensembl - ENSG00000141052
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 si:dkeyp-69b9.3ENSDARG00000088881Danio rerio
 MYOCDENSGALG00000001021Gallus gallus
 MyocdENSMUSG00000020542Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MKL2 / Q9ULH7 / MKL1/myocardin like 2ENSG0000018626037
MKL1 / Q969V6 / megakaryoblastic leukemia (translocation) 1ENSG0000019658836


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004018  RPEL repeat
 IPR028721  Myocardin
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000122 negative regulation of transcription by RNA polymerase II IEA
 biological_processGO:0001560 regulation of cell growth by extracellular stimulus IEA
 biological_processGO:0001570 vasculogenesis IEA
 biological_processGO:0001666 response to hypoxia IEP
 biological_processGO:0003231 cardiac ventricle development IEA
 biological_processGO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation IDA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0008284 positive regulation of cell proliferation IEA
 biological_processGO:0008285 negative regulation of cell proliferation IDA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0010667 negative regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0010832 negative regulation of myotube differentiation IEA
 biological_processGO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0035051 cardiocyte differentiation NAS
 biological_processGO:0035065 regulation of histone acetylation ISS
 biological_processGO:0035886 vascular smooth muscle cell differentiation IEA
 biological_processGO:0042692 muscle cell differentiation IEA
 biological_processGO:0043388 positive regulation of DNA binding IEA
 biological_processGO:0043954 cellular component maintenance IEA
 biological_processGO:0045661 regulation of myoblast differentiation IEA
 biological_processGO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0045987 positive regulation of smooth muscle contraction IDA
 biological_processGO:0048286 lung alveolus development IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0051091 positive regulation of DNA-binding transcription factor activity IDA
 biological_processGO:0051145 smooth muscle cell differentiation IMP
 biological_processGO:0051150 regulation of smooth muscle cell differentiation TAS
 biological_processGO:0051152 positive regulation of smooth muscle cell differentiation IDA
 biological_processGO:0055007 cardiac muscle cell differentiation ISS
 biological_processGO:0055012 ventricular cardiac muscle cell differentiation IEA
 biological_processGO:0060065 uterus development IEA
 biological_processGO:0060157 urinary bladder development IEA
 biological_processGO:0097070 ductus arteriosus closure IEA
 biological_processGO:1900222 negative regulation of amyloid-beta clearance IMP
 biological_processGO:1900239 regulation of phenotypic switching IEA
 biological_processGO:1901228 positive regulation of transcription from RNA polymerase II promoter involved in heart development IEA
 biological_processGO:1903506 regulation of nucleic acid-templated transcription IEA
 biological_processGO:1904706 negative regulation of vascular smooth muscle cell proliferation IEA
 biological_processGO:1904753 negative regulation of vascular associated smooth muscle cell migration IEA
 biological_processGO:2000587 negative regulation of platelet-derived growth factor receptor-beta signaling pathway IEA
 biological_processGO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation IDA
 biological_processGO:2000724 positive regulation of cardiac vascular smooth muscle cell differentiation ISS
 biological_processGO:2000727 positive regulation of cardiac muscle cell differentiation IEA
 biological_processGO:2001015 negative regulation of skeletal muscle cell differentiation IDA
 cellular_componentGO:0000790 nuclear chromatin IEA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000987 proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0001046 core promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001076 transcription factor activity, RNA polymerase II transcription factor binding ISS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
 molecular_functionGO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0003713 transcription coactivator activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IPI
 molecular_functionGO:0035035 histone acetyltransferase binding IEA
 molecular_functionGO:0042826 histone deacetylase binding IEA
 molecular_functionGO:0070412 R-SMAD binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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