ENSG00000186260


Homo sapiens

Features
Gene ID: ENSG00000186260
  
Biological name :MKL2
  
Synonyms : MKL1/myocardin like 2 / MKL2 / Q9ULH7
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: p13.12
Gene start: 14071321
Gene end: 14266773
  
Corresponding Affymetrix probe sets: 1558777_at (Human Genome U133 Plus 2.0 Array)   1558778_s_at (Human Genome U133 Plus 2.0 Array)   1570202_a_at (Human Genome U133 Plus 2.0 Array)   218259_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000460848
Ensembl peptide - ENSP00000459879
Ensembl peptide - ENSP00000460589
Ensembl peptide - ENSP00000339086
Ensembl peptide - ENSP00000458340
Ensembl peptide - ENSP00000459205
Ensembl peptide - ENSP00000459518
Ensembl peptide - ENSP00000459626
NCBI entrez gene - 57496     See in Manteia.
OMIM - 609463
RefSeq - XM_017023505
RefSeq - XM_006720914
RefSeq - XM_011522568
RefSeq - XM_011522569
RefSeq - XM_017023501
RefSeq - XM_017023502
RefSeq - XM_017023503
RefSeq - XM_017023504
RefSeq - NM_001308142
RefSeq - NM_014048
RefSeq - XM_005255452
RefSeq - XM_005255453
RefSeq - XM_005255455
RefSeq - XM_006720908
RefSeq - XM_006720909
RefSeq - XM_006720912
RefSeq - XM_006720913
RefSeq Peptide - NP_001295071
RefSeq Peptide - NP_054767
swissprot - I3L3Z7
swissprot - I3L2A0
swissprot - I3L0U1
swissprot - Q9ULH7
swissprot - I3L2S3
Ensembl - ENSG00000186260
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 mkl2aENSDARG00000088307Danio rerio
 mkl2bENSDARG00000076867Danio rerio
 MKL2ENSGALG00000003026Gallus gallus
 Mkl2ENSMUSG00000009569Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MKL1 / Q969V6 / megakaryoblastic leukemia (translocation) 1ENSG0000019658841
MYOCD / Q8IZQ8 / myocardinENSG0000014105233


Protein motifs (from Interpro)
Interpro ID Name
 IPR003034  SAP domain
 IPR004018  RPEL repeat
 IPR036361  SAP domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007517 muscle organ development IEA
 biological_processGO:0030154 cell differentiation IEA
 biological_processGO:0032515 negative regulation of phosphoprotein phosphatase activity IEA
 biological_processGO:0045844 positive regulation of striated muscle tissue development IDA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0051145 smooth muscle cell differentiation IBA
 cellular_componentGO:0005634 nucleus IBA
 molecular_functionGO:0003713 transcription coactivator activity IDA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004864 protein phosphatase inhibitor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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