| MP:0000266 | abnormal cardiac morphology | "anomalies in the hollow, muscular organ that maintains the circulation of the blood" [MeSH:National Library of Medicine - Medical Subject Headings , 2003] |
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Allelic Composition: Rpl29tm2Udel/Rpl29tm2Udel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0000284 | double outlet right ventricle | "both the aorta and the pulmonary trunk originate from the right ventricle, usually in conjunction with a ventricular septal defect" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:67826] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0000598 | abnormal liver morphology | "malformation or absence of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:CLS, J:23170] |
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Allelic Composition: Rpl29tm2Udel/Rpl29tm2Udel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0000807 | abnormal hippocampus morphology | "absent or malformed deep lying structure of the cerebrum involved with memory storage and spatial navigation" [The Atlas of Mouse Development:ISBN 0-12-402035-6, MGI:Cls, J:38857] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0000812 | abnormal dentate gyrus morphology | "absence or malformation of one of two interlocking gyri of the hippocampus that contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:38857] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0000819 | abnormal olfactory bulb morphology | "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0001182 | lung hemorrhage | "bleeding in the respiratory organs" [J:66345] |
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Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J
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| MP:0001262 | decreased body weight | "lower than normal average weight " [J:61295] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0001634 | internal hemorrhage | "blood loss in the interior of the body due to vessel rupture or dysmorphology " [J:23170] |
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Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J
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| MP:0001718 | abnormal yolk sac | "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623] |
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Allelic Composition: Rpl29tm2Udel/Rpl29tm2Udel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0001722 | pale yolk sac | "bloodless yolk sac" [J:62571] |
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Allelic Composition: Rpl29tm2Udel/Rpl29tm2Udel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
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| MP:0001785 | edema | "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065] |
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Allelic Composition: Ghrtm1Arge/Ghrtm1Arge,Igf1tm1Arge/Igf1tm1Arge
Genetic Background: involves: 129S/SvEv * C57BL/6J * DBA * MF1
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| MP:0001787 | pericardial edema | "accumulation of watery fluid in the pericardial sac of the heart" [J:52597] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
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| MP:0001914 | hemorrhage | "loss of blood from the vascular compartment to the exterior or into nonvascular body space as a result of rupture or severance of the blood vessels" [Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
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| MP:0002169 | no phenotype detected | "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0002191 | abnormal artery morphology | "malformation of the blood vessels that carry blood away from the heart" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J
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| MP:0002196 | acallosal | "absence of the commissural plate interconnecting the cortical hemispheres of the brain" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0002633 | persistent truncus arteriosis | "complete failure of the common arterial trunk opening out of both ventricles to divide into the aorta and pulmonary artery during development" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator] |
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Allelic Composition: Rpl29tm2Udel/Rpl29tm2Udel
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J
Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0002652 | thin myocardial wall | "thinly developed cardiac muscle layers" [il:Ira Lu , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0002672 | abnormal branchial arch artery morphology | "malformation of the vessels formed within the five pairs of branchial arches in embryogenesis; in the adult, some of these vessels give rise to the great vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0003203 | increased neuron apoptosis | "increase in the number of neurons undergoing programmed cell death" [RGD:Rat Genome Database submission] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0003279 | aneurysm | "a protruding sac formed by the dilation of the wall of an artery, a vein, or the heart resulting from a weakening of the vessel wall or heart muscle" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, ncbi:Matthew Mailman, NCBI request] |
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Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J
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| MP:0003566 | abnormal cell adhesion | "altered ability of a cell to adhere to another cell or to a non-cellular component of the environment" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J
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| MP:0003814 | vascular smooth muscle cell hypoplasia | "decreased numbers of smooth muscle cells in the vascular wall" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
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| MP:0003888 | liver hemorrhage | "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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| MP:0004157 | interrupted aortic arch | "complete discontinuation/blockage between the ascending and descending aorta; includes Type A, interruption distal to the subclavian artery that is ipsilateral to the second carotid artery, and Type B, interruption between second carotid artery and ipsilateral subclavian artery" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004158 | right aortic arch | "the aortic arch lies to the right of the trachea and esophagus; results from persistance of the entire right dorsal arch and involution of a segment of the left arch" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0004275 | abnormal postnatal subventricular zone morphology | "any structural anomaly of the mitotically active layer of cells surrounding the brain ventricles in the adult that consists of migrating neuroblasts, astrocytes and transitory amplifying progenitor cells" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator", PMID:12637172] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0004279 | abnormal rostral migratory stream morphology | "any structural anomaly of the transient structure formed by neurons migrating from the subventricular zone into the olfactory bulbs" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0006009 | abnormal neuronal migration | "defective or impaired movement of immature neurons from germinal zones to specific positions where they will reside as they mature" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0006126 | abnormal outflow tract development | "anomaly in the development of the common arterial trunk that forms the aorta and pulmonary artery" [smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Krt71Ca-8J/Krt71+
Genetic Background: involves: DBA/2J
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| MP:0006138 | congestive heart failure | "the heart is unable to adequately pump blood throughout the body" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0006278 | aortic aneurysm | "protruding sac formed by dilation of the aorta" [J:110586, MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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| MP:0006354 | abnormal fourth branchial arch artery morphology | "any structural anomaly of the vessels formed within the fourth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
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| MP:0006355 | abnormal sixth branchial arch artery morphology | "any structural anomaly of the vessels formed within the sixth pair of branchial arches in embryogenesis" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
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| MP:0008227 | absent anterior commissure | "absence of a round bundle of nerve fibers that crosses the midline of the brain near the anterior limit of the third ventricle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0008284 | abnormal hippocampus pyramidal cell layer | |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0009868 | abnormal descending thoracic aorta morphology | "any structural anomaly of the part of the aorta that extends from the arch of the aorta to the diaphragm, and from which arises numerous branches that supply oxygenated blood to the chest cage and the organs within the chest" [http://www.medterms.com "MedicineNet.com"] |
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Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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| MP:0009873 | abnormal aorta tunica media morphology | "any structural anomaly of the middle layer of the aorta wall, containing the smooth muscle layer and elastic fibers" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"] |
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Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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| MP:0009937 | abnormal neuron differentiation | "abnormal growth or development of the cells of the nervous system that receive, conduct, and transmit impulses" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0009939 | abnormal hippocampus neuron morphology | |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0010402 | ventricular septal defect | "abnormal communications between the two lower chambers of the heart, including such defects in the perimembranous, inlet, outlet (infundibular), central muscular, marginal muscular, or apical muscular regions" [MESH:C14.240.400.560.540] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0010418 | perimembraneous ventricular septal defect | "abnormal communications between the two lower chambers of the heart, occurring in the membranous septum with defects in the adjacent muscular portion of the septum; it is generally located in the LV outflow tract just below the aortic valve, associated with pouches or aneurysms of the septal leaflet of the tricuspid valve, which may partially or completely close the defect; an LV-to-RA shunt may also be associated with this defect" [http://emedicine.medscape.com] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
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| MP:0010425 | abnormal heart and great vessel attachment | "any anomaly in the in the position or pattern of the connection site of the heart to any of the primary vessels, including the superior vena cavae, inferior vena cavae, pulmonary artery, pulmonary veins, and aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
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| MP:0010574 | aorta dilation | "the luminal space of the aorta is increased in volume or area, usually with an increase of contained fluid" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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| MP:0010652 | absent aorticopulmonary septum | "absence of the spiral septum that separates the truncus arteriosus into a ventral pulmonary trunk and the dorsal aorta" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0010666 | abnormal vitelline vein morphology | "any structural anomaly of the paired veins that carry blood from the yolk sac back to the embryo" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
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| MP:0011085 | complete postnatal lethality | "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0011090 | partial perinatal lethality | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0011099 | complete lethality throughout fetal growth and development | "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Col4a5tm1Yseg/Y
Genetic Background: B6.Cg-Col4a5tm1Yseg
Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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| MP:0011109 | partial lethality throughout fetal growth and development | "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J
Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg,H2afvTg(Wnt1-cre)11Rth/0
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * CBA/J
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| MP:0011707 | impaired fibroblast cell migration | "failure of cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium" [MGI:csmith] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0012468 | decreased striatum area | "reduced size of a large cluster of dopaminergic nerve cells, consisting of the caudate nucleus and the putamen, that controls movement, balance, and walking" [ISBN:0838580343, MGI:csmith] |
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Allelic Composition: Ndufs4tm1.1Rpa/Ndufs4tm1.1Rpa
Genetic Background: involves: 129S4/SvJaeSor
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| MP:0012729 | abnormal common carotid artery morphology | "any structural anomaly of the left or right common carotid arteries which extend headward on each side of the anterior neck and deliver oxygenated nutrient filled blood from the heart to the head, neck and brain; the left originates in the arch of the aorta over the heart; the right originates in the brachiocephalic trunk, the largest branch from the arch of the aorta; each common carotid artery divides into an external and an internal carotid artery" [MGI:anna] |
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Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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| MP:0012751 | impaired cardiac neural crest cell differentiation | "abnormal or arrest of differentiation or patterning of the cardiac neural crest cells (NCCs), a subpopulation of cranial NCCs originating from the lower hindbrain between the otic placode and third somite; cardiac NCCs have the potential to differentiate into smooth muscle cells of the cardiac outflow tract and its septum, walls of aortic and arch-derived arteries, all of the parasympathetic innervation of the heart, and the connective tissue of the glands in the head and neck region, including the thymus, thyroid and parathyroid glands" [MGI:anna] |
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Allelic Composition: Mkl2Gt(RRJ478)Byg/Mkl2Gt(RRJ478)Byg
Genetic Background: involves: 129P2/OlaHsd
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| MP:0013187 | dilated basilar artery | "stretched or widened aperture of the luminal space of the unpaired artery that is formed by the union of the two vertebral arteries, runs forward within the skull just under the pons, divides into the two posterior cerebral arteries, and supplies the pons, cerebellum, posterior part of the cerebrum, and the inner ear" [MGI:anna] |
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Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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| MP:0030338 | dilated third pharyngeal arch artery | "stretched or widened aperture of the luminal space of the third pharyngeal arch artery" [MGI:anna] |
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Allelic Composition: Mkl2tm1.1Msp/Mkl2tm1.1Msp
Genetic Background: involves: 129
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